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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Organometallics 11 (1992), S. 267-269 
    ISSN: 1520-6041
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 112 (1990), S. 453-455 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 45 (1989), S. 1030-1034 
    ISSN: 1420-9071
    Keywords: Direct digital control ; DDC ; computer ; process control ; biotechnology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary CAROLINE I represents a DDC software package utilizing to full advantage the power of modern microcomputer systems in a multitasking environment. The software in no way imposes restrictions on the number of configurable elements as I/O channels and function calls. More than 100 functions allow a rigorous process control concerning events depending on time and logic. The user interface is adaptable to any process setup by configurable menus whose number is limited only by the memory capacity of the computer. The menu configuration includes graphic layouts and the actions performed in response to operator input. Special data structures allow the integration of data acquired by analytical instruments such as mass spectrometers, IR-analyzers etc. The software is written in ‘C’ and easily portable to any multitasking operating system like OS9, real time UNIX or QNX. The tests were run using OS9 on VME computer systems.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-0428
    Keywords: Streptozotocin ; offspring ; insulitis ; islet perifusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Multiple low doses of streptozotocin (LDS) induce low-incidence diabetes mellitus in Balb/cHan and high-incidence diabetes in CD-1 mice. We studied offspring of diabetic parents in both strains. Group 1 consisted of litters from control mice with no streptozotocin treatment. Group 2 litters had an LDS diabetic mother and a control father, group 3 litters had control mother with LDS diabetic father, and group 4 litters had both, LDS diabetic mother and father. Diabetes was induced by 5×40 mg streptozotocin per kg on five consecutive days. Progeny of diabetic mothers showed a state of reduced glucose tolerance associated with reduced glucose disappearance during intravenous glucose tolerance test and increased insulin secretion of isolated islets of Langerhans. These metabolic abnormalities predominated in the male litters of both strains of mice. Amniotic insulin was increased in diabetic mothers during pregnancy. No histologic abnormalities were observed in group 2 progeny. Pancreases in male offspring of LDS diabetic CD-1 fathers (group 3) were studied for insulitis. Insulitis was found in 40% of mice with normal glucose tolerance. A single subdiabetogenic dose of streptozotocin (40 mg/kg) induced insulitis in 90% of pancreases accompanied by reduced insulin release of isolated islets. By contrast, male Balb/cHan progeny of diabetic fathers failed to develop insulitis. In conclusion, we found (1) parental LDS diabetes was transmitted more often to male offspring, (2) maternal LDS diabetes was associated with hyperinsulin secretion and glucose intolerance in the offspring and (3) paternal LDS diabetes was accompanied by insulitis and insulin secretion deficiency in CD-1 progeny.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Annals of hematology 16 (1967), S. 34-38 
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Annals of hematology 16 (1967), S. 99-103 
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Annals of hematology 19 (1969), S. 38-42 
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Annals of hematology 12 (1965), S. 175-178 
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Annals of hematology 12 (1966), S. 275-280 
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Through individual observations on 25 patients undergoing streptokinase treatment and through in vitro investigations, changes noted in certain coagulation tests caused by streptokinase are reported. It was demonstrated that for a routinely conducted supervision of the coagulation system and for an optimum control of streptokinase administration not one coagulation test alone should be considered, but the collective evaluation of the results of thromboplastin time, thrombin time and heat fibrin determination should be used. Only thus is it possible to judge sufficiently all the changes in the coagulation system caused by streptokinase.
    Notes: Zusammenfassung An Hand von Einzelbeobachtungen bei 25 Patienten, die unter Streptokinase-Behandlung standen, und Untersuchungen in vitro wurde über Veränderungen, durch Streptokinase bedingte, bei bestimmten Gerinnungstesten berichtet. Es wurde dargelegt, daß zur routinemäßig durchführbaren Überwachung des Gerinnungssystems und zur optimalen Steuerung der Streptokinase-Zufuhr nicht ein einzelner Gerinnungstest, sondern die zusammenfassende Auswertung der Ergebnisse der Thromboplastinzeit, Thrombinzeit und Hitzefibrin-Bestimmung herangezogen werden sollte, weil dadurch eine ausreichende Beurteilungsmöglichkeit aller durch die Streptokinase ausgelösten Veränderungen im Gerinnungssystem gegeben ist.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The coagulation factors were estimated in 40 patients with myocardial infarction under long-term treatment with dicumarol derivatives, in 28 patients with cirrhosis of the liver, and in a group of 20 normal persons. In addition to the well-known reduction of factor II, VII, IX, and X, the myocardial infarction group showed also a moderate reduction of factors V and VIII; the liver cirrhosis group showed similar, but more pronounced changes. An unequivocal difference between the influence of coumarin and hepatogenic changes in coagulation, were found in the following points: 1. Coumarin treatment causes no decrease of the fibrinogen level, while cirrhosis of the liver showed a marked decrease of fibrinogen. 2. Under anticoagulation treatment the platelet factor 3 showed normal activity; in cirrhosis of the liver the activity of this factor often showed a strong decrease. 3. No change of the antithrombin II content was found in the anticoagulant group; antithrombin III was distinctly increased. In contrast, cirrhoses of the liver showed a decrease of the antithrombin II and, in a decompensated state, mostly also a considerable decrease of antithrombin III. In cholangitic liver cirrhoses antithrombin II was distinctly increased. Furthermore, the streptokinase resistance test was carried out in 80 normal persons, 45 patients under long-term coumarin treatment, and 20 patients with cirrhosis of the liver. In the anticoagulant group, just as in the group with cirrhosis of the liver, the mean value of this test was significantly lower than in the normal group.
    Notes: Zusammenfassung Bei 40 Patienten mit Myokardinfarkt, die unter Langzeitbehandlung mit Dicumarolderivaten standen, bei 28 Patienten mit Leberzirrhose und bei einer Gruppe von 20 Normalfällen wurden Gerinnungsfaktoren bestimmt. Neben der bekannten Verminderung der Faktoren II, VII, IX und X fand sich in der Gruppe der Myokardinfarkte auch eine mäßige Verminderung der Faktoren V und VIII; die Leberzirrhosen zeigten ähnliche, jedoch stärker ausgeprägte Veränderungen. Ein eindeutiger Unterschied zwischen Cumarin-Einfluß und hepatogen bedingten Gerinnungsveränderungen fand sich in folgenden Punkten: 1. Cumarin-Behandlung verursacht keine Erniedrigung des Fibrinogenspiegels, bei den Leberzirrhosen war das Fibrinogen deutlich vermindert. 2. Der Plättchenfaktor 3 zeigte unter Antikoagulantienbehandlung eine normale Aktivität; bei Leberzirrhosen war die Aktivität dieses Faktors oft stark eingeschränkt. 3. In der Antikoagulantiengruppe fand sich keine Veränderung des Antithrombin-II-Gehalts; das Antithrombin III war deutlich vermehrt. Demgegenüber zeigten Leberzirrhosen eine Verminderung des Antithrombins II und in dekompensiertem Zustand meist auch eine erhebliche Verminderung des Antithrombins III. Bei cholangitischen Leberzirrhosen war Antithrombin II deutlich vermehrt. Außerdem wurde bei 80 Normalfällen, 45 Patienten unter Cumarin-Langzeitbehandlung und bei 20 Leberzirrhosen der Streptokinase-Resistenztest durchgeführt. In der Antikoagulantiengruppe gleicherweise wie in der Gruppe der Leberzirrhosen lag der Mittelwert für diesen Test signifikant tiefer als bei der Gruppe der Normalfälle.
    Type of Medium: Electronic Resource
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