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  • 1
    Electronic Resource
    Electronic Resource
    Behandlung des hyperkinetischen Herzsyndroms mit Alinidine und Propranolol (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 69-75 
    Details
    ISSN: 1432-1440
    Keywords: Hyperkinetic heart syndrome ; Bradycardic drugs ; Alinidine (ST 567) ; Propranolol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A hyperkinetic heart syndrome has been diagnosed in 10 patients by clinical investigation and right-heart catheterization at rest and during exercise. Subsequently, the patients received 3×40 mg alinidine, and 2×40 mg propranolol and placebo, each for 2 weeks in a double-blind cross-over study. Heart rate at rest (P〈0.05) and during exercise (P〈0.001) decreased significantly under alinidine and propranolol to the same extent (control, 83/170; alinidine, 68/146; propranolol, 73/139; placebo, 83/162 beats per min). Lower limb flow at rest and after exercise, measured by plethysmography, as well as left-ventricular fractional shortening and mean velocity of circumferential fiber shortening, measured by echocardiography, decreased insignificantly. Sedation and a dry mouth occurred in six patients under alinidine, while fatigue and cold hands and/or feet were reported by five patients under propranolol. Thus, alinidine may be used as an alternative to beta-blocking in the treatment of the hyperkinetic heart syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01745476
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  • 2
    Electronic Resource
    Electronic Resource
    Influence of carvedilol and propranolol on coronary blood flow (1990)
    Springer
    European journal of clinical pharmacology 38 (1990), S. S122 
    Details
    ISSN: 1432-1041
    Keywords: carvedilol ; propranolol ; coronary blood flow ; beta-blockade ; vasodilation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A total of 17 patients with angiographically proven coronary artery disease and at least one stenosis blocking ≥ 70% of the left anterior descending or circumflex artery were included in a double-blind, randomized study. They received either 5 mg carvedilol or 6 mg propranolol intravenously. Heart rate, aortic pressure, mean coronary sinus pressure and coronary flow (thermodilution) were measured and coronary resistance and the rate-pressure product were calculated before and 25 min after injection. Carvedilol significantly (P 〈 0.05) lowered the heart rate (mean, 76 to 69 beats/min), aortic pressure (mean, 153/80–135/72 mmHg), rate-pressure product (mean, 117–93 mmHg/min), and coronary flow (mean, 114–94 ml/min). Coronary resistance (mean, 0.97–1.07 mmHg × min/ml) and coronary flow related to the rate-pressure product (mean, 1.0–1.02 ml/mm Hg) showed no significant change after carvedilol treatment. Propranolol lowered the heart rate (mean, 76–64/min;P 〈 0.05) and rate-pressure product (mean, 109–96 mm. Hg/min; not significant). Aortic pressure (mean, 145/72–147/74 mmHg), coronary flow (mean 109–101 ml/min), coronary resistance (mean, 1.1–1.2 mmHg × min/ml), and coronary flow related to the rate-pressure product (mean,1.12–1.19 ml/mmHg) showed no significant change after propranolol administration. Following single application, carvedilol lowered the rate-pressure product more markedly than did propranolol on account of its acute blood-pressure-lowering effect. No differences in the hemodynamic effects of carvedilol and propranolol were found. Neither drug seems to influence the adaption of coronary flow to myocardial oxygen demand.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01409480
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  • 3
    Electronic Resource
    Electronic Resource
    Ein neues System zum transvenösen Verschluß des persistierenden Ductus arteriosus (1997)
    Springer
    Zeitschrift für Kardiologie 86 (1997), S. 56-61 
    Details
    ISSN: 1435-1285
    Keywords: Key words Patent ductus arteriosus – transvenous closure – Ivalon ; Schlüsselwörter Persistierender Ductus arteriosus – transvenöser Verschluß– Ivalon
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary An Ivalon-plug (PDA-plug) has been developed for transvenous closure of patent ductus arteriosus. It can be introduced into the ductus through standard venous sheaths with a diameter von 8–16 French. The plug is fixed in its target position by means of four distal (aortal) and two proximal (pulmonary) nitinol struts. In case of malpositioning the system can be pulled back into and retrieved through the sheath. In animal experiments endothelialization of the implanted material was demonstrated. PDA-closure was attempted in 58 patients; the procedure was successful in 57 cases; a residual ductal flow was present in eight patients. During a follow-up of up to 24 months there were no complications.
    Notes: Zusammenfassung Es wurde ein Ivalonpfropf (PDA-Plug) zum transvenösen Verschluiß des persistierenden Ductus arteriosus entwickelt. Er kann durch Standardschleusen vom Kaliber 8–16 French in den Ductus eingeführt werden. Mit 4 distalen (aortalen) und 2 proximalen (pulmonalen) Nitinol-Federbeinchen wird das System im Ductus fixiert. Bei Fehlplazierung kann der Propf in die Schleuse zurückgezogen und entfernt werden. In Tierexperimenten wurde eine Endothelialisierung des implantierten Materials nachgewiesen. Bisher wurde bei 58 Patienten ein Ductusverschluß versucht; in 57 Fällen gelang der Eingriff, ein Residualshunt war bei 8 Patienten nachweisbar. Im Verlauf von bis zu 24 Monaten traten keine Komplikationen auf.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003920050034
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  • 4
    Electronic Resource
    Electronic Resource
    Ballondilatation valvulärer Pulmonalstenosen bei Erwachsenen (1997)
    Springer
    Zeitschrift für Kardiologie 86 (1997), S. 1026-1032 
    Details
    ISSN: 1435-1285
    Keywords: Key words Balloon valvuloplasty – pulmonary stenosis – long term follow-up – adults ; Schlüsselwörter Ballonvalvuloplastie – Pulmonalstenose – Langzeitverlauf – Belastungsgradient – Erwachsene
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Balloon valvuloplasty of pulmonary stenosis has become the treatment of choice in children and adults. This is a report about the long term results in adult patients. Forty-six patients (mean age 37 ± 17 years) with pulmonary stenosis were treated between 1984 and 1994 by this method. Thirty-four of 46 patients were re-examined 3 months to 9 years (mean 3.4 years) later by right heart catheterization and echocardiography. These 34 patients were representative for the whole group concerning age, severity of the pulmonary stenosis, and acute results after the intervention. The pressure gradient was acutely reduced by balloon valvuloplasty from 86 ± 35 to 38 ± 17 mm Hg (p 〈 0.0001) (n = 46) and was 32 ± 10 mm Hg (n.s.) (n = 34) at follow-up. Within 3 months after the intervention, 8 of 13 patients with a pressure gradient ≥ 100 mm Hg, showed spontaneously further reduction of the gradient due to the resolution of the subvalvular muscular hypertrophy. During a bicycle exercise test with 9 patients, the gradient rose significantly from 29 ± 10 to 53 ± 23 mm Hg (p 〈 0.01) as determined by right heart catheterization. All of these patients had normal cardiac output at rest and during exercise. None had signs of right ventricular hypertrophy in the electro- or echocardiogram. It is concluded that balloon valvuloplasty of pulmonary stenosis is the first line treatment in adults.
    Notes: Zusammenfassung Die Behandlung von valvulären Pulmonalstenosen mittels Ballondilatation ist heute die Therapie der Wahl im Kindes- und Erwachsenenalter. Wir berichten über das Dilatationsergebnis von 46 erwachsenen Patienten (mittleres Alter 37 ± 17 Jahre) mit Pulmonalstenose, die zwischen 1984 und 1994 mit diesem Verfahren behandelt worden sind. 34 von 46 Patienten wurden 3 Monate bis 9 Jahre (im Mittel 3,4 Jahre) nach Intervention mittels Rechtsherzkatheterisierung und Echokardiographie nachuntersucht. Diese 34 Patienten waren bezüglich Alter, Schwere der Pulmonalstenose und Akutergebnis nach Dilatation repräsentativ für das Gesamtkollektiv. Der maximale Druckgradient wurde durch Ballonvalvuloplastie akut von 86 ± 35 auf 38 ± 17 mm Hg (p 〈 0,0001) (n = 46) reduziert und war 32 ± 10 mm Hg (n.s.) (n = 34) zum Zeitpunkt der jeweils letzten Nachuntersuchung. 8 von 13 Patienten mit einem maximalen Druckgradienten ≥ 100 mm Hg zeigten eine weitere spontane Reduktion des Gradienten infolge Rückbildung einer subvalvulären muskulären Hypertrophie des rechten Ausflußtraktes innerhalb von 3 Monaten nach dem Eingriff. Eine fahrradergometrische Untersuchung im Liegen wurde bei 9 Patienten durchgeführt. Hierbei stieg der invasiv gemessene maximale Gradient signifikant von 29 ± 10 auf 52 ± 23 mm Hg (p 〈 0,01) an. Sämtliche Patienten hatten ein normales Herzzeitvolumen in Ruhe und unter Belastung. Keiner zeigte elektro- oder echokardiographisch die Zeichen einer rechtsventrikulären Hypertrophie. Die Ballonvalvuloplastie der valvulären Pulmonalstenose ist die Therapie der Wahl bei Erwachsenen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003920050145
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  • 5
    Electronic Resource
    Electronic Resource
    Quarzstaub als Adjuvans beim Entstehen einer zellvermittelten Immunität (1980)
    Springer
    Naturwissenschaften 67 (1980), S. 569-569 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00450675
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  • 6
    Electronic Resource
    Electronic Resource
    Changes in myocardial substrate utilisation and protection of ischemic stressed myocardium by oxfenicine [(S)-4-hydroxyphenylglycine] (1984)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 327 (1984), S. 70-74 
    Details
    ISSN: 1432-1912
    Keywords: Cardiac metabolism ; Myocardial ischemia ; Oxfenicine ; Oxygen debt ; Oxygen repayment ; Release of electrolytes and substrates
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Potential protective effects of oxfenicine [(S)-4-hydroxyphenylglycine] in ischemic stressed canine myocardium have been studied. This compound is characterized as a drug leading to metabolic inhibition of free fatty acid (FFA) metabolism. The drug (0.06 mmol·kg−1 body weight) caused no changes in hemodynamics or energy demand (Et) but depressed myocardial oxygen consumption (MVO2) by 11% (P〈0.02). Significant changes in FFA and lactate metabolism were observed: lactate extraction (EX) increased from 22.5–37.1 μmol/min, extraction ratio (EXR) from 16.5–30% and oxygen extraction ratio (OER) from 24.8–38%; EX of FFA decreased from 6900–5000 nmol/min, EXR from 48.2–31.4% and OER from 59.7–46.6%. Arterial concentrations of FFA and lactate remained unchanged. EX, EXR and OER of glucose were not affected under basic conditions. In the same collective, repeated ischemia (3 min) was produced by proximal occlusion of the left anterior descending artery (LAD). The efficiency of the drug was examined by (a) the amounts of ischemia metabolites released in the early reperfusion and (b) quantification of O2-debt and O2-repayment in the occlusion- and reperfusion periods. Compared to control occlusions, premedication led to a reduced O2-debt (P〈0.01) combined with a reduced amount of oxygen additionally taken up in the early reperfusion (P〈0.05). Furthermore, release of potassium increased (+7.1%; P〈0.05); release of lactate (-32%, P〈0.001) and inorganic phosphate (-34%, P〈0.01) decreased. These data give support to the concept that a pharmacologically induced shift of cardiac metabolism with reduction of FFA utilisation may be favourable in circumstances with limited oxygen supply.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00504994
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  • 7
    Electronic Resource
    Electronic Resource
    Effectiveness of nicorandil in the preservation of myocardium stressed by transient ischemia and its influence on cardiac metabolism during coronary artery occlusion with subsequent reperfusion: a comparison with isosorbide dinitrate (1985)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 329 (1985), S. 440-446 
    Details
    ISSN: 1432-1912
    Keywords: Cardiac metabolism ; Ischemia ; Isosorbide dinitrate ; Nicorandil ; Oxygen-debt ; Oxygen-repayment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This study was designed to investigate the effects of nicorandil in comparison to isosorbide dinitrate (ISDN) on hemodynamics, on myocardial metabolism and on effectiveness in the preservation of ischemically stressed myocardium. Repeated ischemia (3 min) was produced in anaesthetized open-chest mongrel dogs by proximal, intermittent left anterior descending artery occlusion with subsequent reperfusion. In each experiment 2–3 control occlusions were compared to 2–3 occlusions under nicorandil or ISDN. Application of both nicorandil (0.64 μmol·kg−1 body weight, i.v.) and ISDN (1.27 μmol·kg−1 body weight, i.v.) led to a significant afterload reduction and to a decrease of the coronary vascular resistance. The efficiency of the compounds in the protection of ischemic myocardium was examined by quantification of oxygen-debt and oxygen-repayment in the occlusion and reperfusion periods. Compared to control, premedication with nicorandil led to a significant increase of oxygen-debt, whereas ISDN reduced it significantly. Oxygen-repayment remained unchanged. The influence of the drugs on the metabolism of glucose, lactate and free fatty acids (FFA) was examined under basic conditions, in ischemia and during reperfusion. For all substrates, extraction, extraction ratio and oxygen extraction ratio were calculated. Under basic conditions, glucose metabolism was significantly enhanced in both groups but FFA metabolism was inhibited only by ISDN. In ischemia, FFA metabolism was enhanced by nicorandil and depressed by ISDN. Data obtained in this study suggest that nicorandil may even aggravate the metabolic and energetic situation of ischemic myocardium and, on the other hand, clearly support the well documented protective effects of ISDN.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00496379
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  • 8
    Electronic Resource
    Electronic Resource
    Estimation of myocardial blood flow heterogeneity by transorgan helium transport functions (1984)
    Springer
    Pflügers Archiv 401 (1984), S. 217-222 
    Details
    ISSN: 1432-2013
    Keywords: Inert gas dilution method ; Deconvolution ; Circulatory transport function ; Indicator transit time ; Heterogeneity of myocardial blood flow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Following single breath inhalations of helium 49 simultaneous inlet-outlet pairs of helium dilution curves were recorded in seven dog experiments from the aortic and coronary sinus blood by use of mass spectrometric technique. After numeric deconvolution of the dilution curves the weighting function of tracer transit times was used for calculation of the mean myocardial blood flow per unit of tissue, which closely correlated with directly measured flow. Secondly, the degree of blood flow heterogeneity was estimated from the first moments of the weighting function of transit times and by compartmental analysis based on an inverse Laplace transform. In the intact heart the results suggest a rather constant dispersion of flows relative to the mean flowFF in the order of σ/FF=0.3. The apparent dispersion of flows is increased by α-adrenergic stimulation with pressure and volume load, particularly in a state of β-blockade, a finding, which may be attributed to variations of intercapillary distances and to a heterogeneity of blood flow per unit of tissue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00582586
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