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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Annals of hematology 12 (1966), S. 249-252 
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Annals of hematology 12 (1966), S. 357-362 
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 56 (1978), S. 727-729 
    ISSN: 1432-1440
    Keywords: Knochenmark ; Histologie ; Bone marrow ; Histology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Histological sections of methacrylate-embedded bone marrow biopsies allow exact evaluation and classification of the cellular marrow components. We describe a simple method for preparation of sections of aspirated bone marrow particles following embedment in methacrylate. Comparison of histological sections from marrow particles and marrow biopsies demonstrated identical quality. Thus, preparation of methacrylate-embedded particle histologies will frequently abrogate the need for marrow biopsies performed in addition to a marrow aspiration. Routine preparation of both cytological and histological preparations from aspirated bone marrow allows more exact assessment of the bone marrow than cytological evaluation only.
    Notes: Zusammenfassung Histologische Schnitte methacrylat-eingebetteter Knochenmarksbiopsien erlauben wegen der hervorragend erhaltenen Zellstrukturen eine genaue Beurteilung des Knochenmarks. Wir haben eine einfache Methode entwickelt, um aspirierte Knochenmarksbröckel nach Methacrylateinbettung histologisch aufzuarbeiten. Die histologischen Präparate solcher Bröckelhistologien zeigen eine den üblichen Knochenmark-Nadelbiopsien vergleichbare Qualität. Methacrylat-eingebettete Bröckelhistologien machen so häufig eine zusätzlich zur Knochenmarkaspiration durchgeführte Knochenmarkbiopsie überflüssig. Routinemäßige Anfertigung zytologischer und bröckelhistologischer Präparate aus aspiriertem Mark erlaubt eine genauere Beurteilung des Markes als die zytologische Untersuchung alleine.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 60 (1982), S. 1455-1459 
    ISSN: 1432-1440
    Keywords: Interferon ; Antiproliferative effect ; Colony tumor growth ; Solid malignant tumors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The antiproliferative effect of fibroblast interferon (IF-β) on the colony tumor growth of 42 miscellaneous carcinomas (15 gastric, 11 breast, eight colon, five ovarian, three bronchial) and two malignant melanomas were assayed in a semisolid, double-layered agar culture system. Of the 44 evaluable experiments only four tumor specimens (three breast-, one gastric carcinoma) showed at least a 30% inhibition of colony formation due to application of interferon at concentration of 1,000 IU/ml or less. In these cases, a dose response relationship of the interferon effect was obvious. Yet, in the majority of carcinomas investigated, interferon had no antiproliferative influence on colony tumor growth and was markedly inferior to a simultaneously tested cytostatic agent (adriamycin). Our in vitro results contradict a general direct cytotoxic action of interferon on human solid carcinomas.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 26 (1967), S. 334-338 
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Steroid Biochemistry 28 (1987), S. 178 
    ISSN: 0022-4731
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 0022-4731
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 347 (1978), S. 711-711 
    ISSN: 1435-2451
    Keywords: Gastrectomy ; Stomach cancer ; Cancer, reconstruction ; Chemotherapy ; Magen ; Carcinom ; Gastrektomie ; Magenersatz ; Chemotherapie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Anhand des Krankengutes der chirurgischen Universitätsklinik Ulm von 1960–1976 werden die Behandlungsergebnisse und 5-Jahres-Überlebenszeiten von 947 Patienten, die wegen eines Magencarcinoms behandelt wurden, dargestellt. Besonders herausgestellt wird die Zunahme der Frühcarcinome infolge der intensivierten präoperativen Diagnostik. Die makroskopischen und histologischen Wachstumsformen werden aufgeführt und die sich daraus ergebenden Konsequenzen für die chirurgische Therapie abgeleitet. Es ergibt sich, daß bei Patienten unter 70 Jahren die Gastrektomie im Prinzip Anwendung finden sollte. Es wird auf die Vorteile geeigneter Rekonstruktionsverfahren hingewiesen. Ferner werden die gebräuchlichen Chemotherapie-Schemata aufgefuhrt und die an der Universität Ulm laufende adjuvante Studie erwähnt.
    Notes: Summary Based on 947 patients operated on for gastric carcinoma between 1960 and 1976, results and 5-years survival times are demonstrated. Due to intensified preoperative diagnostic methods, there is an increase in early gastric cancer. Adequate surgical measures are related to the specific morphologic and histologic behavior of the gastric cancer. It is concluded that total gastrectomy should be performed in patients under 70 years of age. Suitable reconstructive procedures seem to be of value. Furthermore, chemotherapeutic treatment is dicussed, and our controlled randomized adjuvant therapy study presented.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 345 (1977), S. 647-647 
    ISSN: 1435-2451
    Keywords: Breast cancer ; Diagnosis ; Treatment ; Mamma-Carcinom ; Diagnose ; Therapie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: ZusammenfaBung Durch die Übereinstimmung der an Diagnostik, Therapie und Nachsorge des Mamma-Ca. beteiligten Disziplinen der Univ.-Kliniken Ulm gelang im Rahmen des Onkologischen Arbeitskreises der Univ. Ulm die Aufstellung einheitlicher Diagnostik und Therapierichtlinien. Die einzelnen Verfahren in derDiagnostik-obligat („Tripel-Diagnostik”) und fakultativ -undTherapie — chirurgische Primärtherapie, adjuvante Chemoimmunotherapie, Zusatztherapieformen, Netzplastik, Chemotherapieprotokolle beim metastasierenden M.C. - werden dargestellt und mit eigenen ErgebniBen belegt.
    Notes: Summary By agreement of the different divisions of the University Hospital in Ulm involved in the diagnosis, treatment, and postoperative follow-up program for breast cancer, it was poBible to establish a uniform regimen for diagnosis and treatment. The particular procedures indiagnosis-obligatory (“triple diagnosis”) and optional-and treatment-primary surgical therapy, adjuvant chemoimmunotherapy, additional treatment forms, omentum plastic, protocols of chemotherapy for advanced breast cancer-are demonstrated and documented with own results.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-1335
    Keywords: Interferon plus MPA ; Advanced renal cell cancer ; Medroxyprogesterone acetate (MPA)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The response rates in metastatic renal cell cancer (RCC) after chemotherapy, hormonal treatment, or immunotherapy rarely exceed 15%. Recently, interferon alpha (IFNα) was used for treatment of this disease in several studies which also demonstrated response rates of 15%. In order to test whether IFN therapy combined with hormones would result in higher response rates we compared single agent IFN therapy with a combined therapy of rIFNα 2C plus medroxyprogesterone acetate (MPA) in a randomized multicenter trial. The rIFNα 2C (2MU) was given s.c. 5 times per week for 8–12 weeks and subsequently once weekly until week 48. In the combined treatment, 750 mg MPA was given p. o. daily until week 48 in addition to the IFN as described. The overall response rate in 93 evaluable patients was 5.4%, corresponding to 2 complete and 3 partial responses. Median survival was 7 months in both treatment groups. These data confirm the ineffectivity of low IFN doses for treatment of RCC. The low response rate is not increased by addition of MPA to IFN. The analysis of other IFN studies suggests that not only IFN doses but also IFN sources may influence response rates in metastatic RCC.
    Type of Medium: Electronic Resource
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