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  • 1
    Electronic Resource
    Electronic Resource
    Early diagnosis of multiple endocrine neoplasia type IIa (1989)
    Springer
    Journal of molecular medicine 67 (1989), S. 951-956 
    Details
    ISSN: 1432-1440
    Keywords: Multiple endocrine neoplasia type IIa ; Pheochromocytoma ; Medullary thyroid carcinoma ; Hyperparathyroidism ; Chromosome banding studies ; DNA linkage analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We report on incidental findings during family screening of two kindreds with multiple endocrine neoplasia type IIa. Pheochromocytoma and medullary thyroid carcinoma of considerable size were detected. The results underline the importance of early diagnosis of the syndrome, since the afflicted may be almost or wholly asymptomatic. High resolution chromosome banding studies were carried out in both families, but no abnormality was found. Linkage analysis using DNA markers closely related to the chromosomal locus at chromosome 10 was carried out and was positive in two asymptomatic offspring of one family, whereas the markers were not informative in a second family. We recommend early linkage analysis for establishing the genetic status in offspring of multiple endocrine neoplasia type IIa families to identify for further screening those who are predicted to be gene carrier.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01721424
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  • 2
    Electronic Resource
    Electronic Resource
    Relationship between blood flow and radiostrontium uptake in the healing bone fracture (1979)
    Springer
    European journal of nuclear medicine 4 (1979), S. 413-417 
    Details
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The healing of a diaphyseal tibia fracture was followed in the rat. Callus formation, blood flow and Sr-85 uptake were assessed by a ratio comparison of the fractured to the contralateral side. No correlation was found between blood flow and Sr-85 deposition in the callus and the adjacent bone of the same extremity. It is concluded that the deposition of a radiopharmaceutical in bone is primarily related to the presence of calcifiable organic bone matrix and only secondarily to the bone formation rate and to variations in the local blood flow.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00300837
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  • 3
    Electronic Resource
    Electronic Resource
    The short-term fixation of radiopharmaceuticals in bone (1979)
    Springer
    European journal of nuclear medicine 4 (1979), S. 423-428 
    Details
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The relationship between local blood flow and bone clearance of 18 F, 32 P-P (orthophosphate), 32 P-PPi (pyrophosphate), 45 Ca, 85 Sr, 99mTc- and 113 Sn-EHDP was evaluated in the non-adult rat. During one single blood passage nearly 100% of 18 F was extracted in the femoral diaphysis, the extraction efficiency for the other radiopharmaceuticals was about 40%. Blood flow and bone clearance was higher and the extraction efficiency lower in the distal femoral epiphysis including the growth plate. The short-term bone uptake of 32 P-P was lowered considerably by the simultaneous application of inactive orthophosphate, whereas the bone uptake of 32 P-PPi was not suppressed. It is suggested that the rapid deposition of radiopharmaceuticals in bone is not caused by an ionic exchange process on crystal surfaces of already existing mineral but is due to an ionic exchange during the precipitation of calcium phosphate in the calcifying bone matrix. Only 18 F is exchanged with hydroxyl groups of already precipitated hydroxyapatite, whereas the calcium and phosphate ions in the precipitated hydroxyapatite are not further accessible to an exchange process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00300839
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  • 4
    Electronic Resource
    Electronic Resource
    Untersuchungen zum Kohlenhydratstoffwechsel in der Leber während der Gestation (1970)
    Springer
    Archives of gynecology and obstetrics 208 (1970), S. 353-372 
    Details
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In der Leber trächtiger Batten finden sich signifikante Aktivitätssteigerungen der Lactat-Dehydrogenase, der Fructose-diphosphat-Aldolase, der Glycerinaldehydphosphat-Dehydrogenase, der Pyruvat-Kinase und der Hexokinase. Enolase und Phosphoglycerat-Kinase zeigen im Vergleich mit den Normaltieren unveränderte Aktivitäten. Die Aktivität der Glucose-6-phosphat-Dehydrogenase ist zu Anfang der Gestation erhöht und nimmt im weiteren Verlauf ab. Eine erhebliche und vom Verlauf der Trächtigkeit unabhängige Aktivitätsverminderung besteht im Falle der Glucose-6-phosphatase. Bei der Bestimmung der stationären Konzentrationen einiger Metaboliten des Kohlenhydratumsatzes in der Leber trächtiger Ratten ergibt sich eine signifikante Herabsetzung der Mengen an Glucose-6-phophat, Fructose-6-phosphat, Dihydroxyaceton-phosphat und Fructose-1,6-disphosphat. Sowohl der Glucosegehalt der Leber als auch der Glucosespiegel des peripheren Blutes nehmen während der Gestation erheblich ab. Die Veränderungen der stationären Pyruvatkonzentration in der Leber und des Pyruvatgehaltes im Blut sind dagegen nicht signifikant.
    Notes: Summary In the liver of pregnant rats significant rises of activity of lactate-dehydrogenase, of fructose-diphosphate-aldolase, of glycerinaldehydphosphate-dehydrogenase, of the pyruvate-kinase and of the hexokinase can be found. Enolase and phosphoglycerate-kinase show unchanged activities compared with normal animals. The activity of glucose-6-phosphate-dehydrogenase is elevated at the beginning of gestation and decreases with progression of pregnancy. A significant decrease of activity which is independent of the course of gestation exists in the case of glucose-6-phosphatase. The determination of the stationary concentrations of some metabolites of the carbohydrate metabolism in the liver of pregnant rats reveals a significant lowering of the amounts of glucose-6-phosphate, fructose-6-phosphate, dihydroxyacetone-phosphate and fructose-1,6-diphosphate. The glucose content of the liver as well as the glucose level of the peripheral blood decrease significantly during gestation. Against this are alterations of the stationary pyruvate-concentration in the liver and of the pyruvate content of the blood not significant.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00668251
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  • 5
    Electronic Resource
    Electronic Resource
    Nuklearmedizinische Diagnostik der Lunge (2000)
    Springer
    Der Radiologe 40 (2000), S. 878-887 
    Details
    ISSN: 1432-2102
    Keywords: Schlüsselwörter Lunge ; Ventilation ; Perfusion ; Rechts-links-Shunt ; Lungenembolie ; Bronchialkarzinom ; Keywords Lung ; Ventilation ; Perfusion ; Right-left-shunt ; Pulmonary embolism ; Lung cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Scintigraphic recording of regional ventilation and perfusion with 99mTc-Aerosol and 99mTc-MAA remain in the foreground of nuclear medicine pulmonary diagnostics. The most important indication for ventilation scintigraphy is the prediction of postoperative pulmonary function, wich is still performed in many hospitals wth perfusion scintigraphy, and with which, in turn, intrapulmonary right-left shunts can be simply and also semiquantitatively recorded. Combined ventilation/perfusion scintigraphy offers a very high degree of sensitivity in the proof of acute pulmonary embolism, is therefore exceptionally well suited for exclusion diagnostics, while specificity compared to pulmonary angiography and spiral CT still needs some clarification. The self-cleaning mechanism of the lung can be quantitatively examined using mucociliary and resorptive clearance. The clinical areas of application are limited for methodical reasons. Primary diagnostics of bronchial carcinoma and dignity differentiation of solitary pulmonary nodules, preferably with 18F-FDG PET are gaining steadily in importance.
    Notes: Zusammenfassung Im Vordergrund der nuklearmedizinischen Lungendiagnostik steht nach wie vor die szintigraphische Abbildung der regionalen Ventilation und Perfusion mit 99mTc-Aerosol und 99mTc-MAA. Wichtigste Indikation für die Ventilationsszintigraphie ist die Voraussage der postoperativen Lungenfunktion, die vielerorts noch mit der Perfusionsszintigraphie durchgeführt wird, mit der sich wiederum intrapulmonale Rechts-links-Shunts einfach und auch semiquantitativ erfassen lassen. Die kombinierte Ventilations-/Perfusionsszintigraphie bietet ein Höchstmaß an Sensitivität beim Nachweis der akuten Lungenembolie, ist deshalb für die Ausschlussdiagnostik hervorragend geeignet, die Spezifität im Vergleich zur Pulmonalisangiographie und Spiral-CT ist weiterhin klärungsbedürftig. Die Selbstreinigungsmechanismen der Lunge lassen sich mit der mukoziliären und resorptiven Clearance quantitativ erfassen, die klinischen Einsatzgebiete sind auch aus methodischen Gründen beschränkt. Zunehmende Bedeutung erlangen die Primärdiagnostik des Bronchialkarzinoms sowie die Dignitätsabklärung solitärer Lungenrundherde vorzugsweise mit 18F-FDG PET.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001170050847
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  • 6
    Electronic Resource
    Electronic Resource
    122. Differenzierte Therapie der Schilddrüsencarcinome (1985)
    Springer
    Langenbeck's archives of surgery 366 (1985), S. 591-591 
    Details
    ISSN: 1435-2451
    Keywords: Thyroid carcinomas ; Interdisciplinary therapy concept ; Survival rates ; Schilddrüsencarcinome ; Interdisziplinäres Therapiekonzept ; Überlebensraten
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Von 1960–1983 wurden 423 Patienten mit Schilddrüsencarcinomen behandelt. Bei folliculären, medulldren und anaplastischen Carcinomen wurde die Thyreoidektomie angestrebt. Die Hemithyreoidektomie mit Keilexcision der gesunden Seite erfolgte beim papillären Carcinom mit einseitigem Befall. Nach Thyreoidektomie wurde die Hormontherapie durchgeführt. Anaplastische Carcinome wurden postoperativ extern bestrahlt. Die Zehnjahresüberlebensraten betrugen beim folliculären Carcinom ohne Metastasen 65%, mit Metastasen 30%, beim papillären Carcinom ohne Metastasen 90%. Nur 50% der Patienten mit medullarem Carcinom überlebten 5 Jahre. Beim anaplastischen Carcinom starben 80% innerhalb von 6 Monaten.
    Notes: Summary From 1960 to 1983, 423 patients with thyroid carcinoma were treated. In follicular, medullary, and anaplastic carcinomas, thyroidectomy was carried out where possible. Hemithyroidectomy with wedge excision of the healthy side was performed in unilateral papillary carcinoma. After thyroidectomy, hormone therapy was given. Anaplastic carcinomas were postoperatively irradiated externally. The 10-year survival rates were 65% in follicular carcinoma without metastases, 30% in follicular carcinoma with metastases, and 90% in papillary carcinoma without metastases. Only 50% of the patients with medullary carcinoma survived for 5 years. Among anaplastic carcinoma cases, 80% died within 6 months.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01836721
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  • 7
    Electronic Resource
    Electronic Resource
    36. Operationsindikation bei Strumaknoten (1986)
    Springer
    Langenbeck's archives of surgery 369 (1986), S. 203-205 
    Details
    ISSN: 1435-2451
    Keywords: Thyroid nodules ; Ultrasonography ; Scintigraphy ; Fine-needle biopsy ; Strumaknoten ; Sonographie ; Szintigraphie ; Feinnadelpunktion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Von 1980–1985 wurden 1839 Patienten mit Schilddrüsenknoten untersucht. Sonographisch wiesen 98 % der Strumaknoten echoarme oder komplexe Strukturen auf. Bei 85 % war die Radionuklidspeicherung herabgesetzt, 10 % (n = 182) waren cytologisch positiv oder suspekt. Von diesen 182 Patienten wurden 60 operiert und 122 regelmäßig nachuntersucht. Bei 35 der 60 operierten Patienten konnte histologisch ein Schilddrüsencarcinom nachgewiesen werden. Die Kombination von echoarmer Raumforderung, szintigraphisch kaltem Knoten und cytologisch positivem oder auch nur suspektem Befund erfordert dringend die Operation.
    Notes: Summary From 1980 to 1985 1,839 patients with thyroid nodules were investigated. 98 % of them showed ultrasonic patterns of either echo-poor or complex structures, 85 of the nodules were scintigraphically cold, in 10% (n = 182) cytological findings were positive or at least suspect. Of these 182 patients 60 underwent operation, whereas 122 were followed up continuously. In 35 of 60 patients operated histological examination confirmed thyroid carcinomas. The combination of echo-poor, cold nodules and cytological positive or suspect findings urgently requires operation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01274353
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  • 8
    Electronic Resource
    Electronic Resource
    Scintigraphic assessment of leukocyte infiltration in acute pancreatitis using technetium-99m-hexamethyl propylene amine oxine as leukocyte label (1991)
    Springer
    Digestive diseases and sciences 36 (1991), S. 65-70 
    Details
    ISSN: 1573-2568
    Keywords: leukocyte scintigraphy ; technetium-99m-hexamethyl propylene amine oxine ; acute pancreatitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The infiltration of leukocytes has been linked to the pathophysiology of complicated or severe pancreatitis. We have tested the ability of leukocyte scintigraphy using technetium-99m-hexamethyl propylene amine oxine (HM-PAO) as label to demonstrate the localization of leukocytes in the pancreas during acute pancreatitis. Twenty-eight patients with acute pancreatitis (eight with biliary, 13 with alcoholic, and seven with unknown origin) were studied with leukocyte scintigraphy using planar imaging and single photon emission computed tomography (SPECT). Fourteen patients had a mild (group I), 11 a severe (group II), and three a lethal outcome (group III) of pancreatitis. All patients of group III, six of group II, and two of group I had a positive leukocyte scan. Thus, the sensitivity of leukocyte scintigraphy for the detection of a lethal course, of acute pancreatitis was 100%, of a severe course 54%, and of a severe or lethal course 64%. The specificity of a negative scan for a mild pancreatitis was 86%. Comparison of the results of leukocyte scintigraphy with those of contrast enhanced CT showed that six of eight patients with pancreatic necrosis in CT had a positive leukocyte scan, but only five of 20 patients without detectable pancreatic necrosis in CT. In summary, leukocyte infiltration into the pancreas during pancreatitis can be demonstrated by noninvasive leukocyte scintigraphy using technetium-99m-HM-PAO as label. A correlation between the severity of the disease and leukocyte infiltration exists.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01300089
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