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  • 1
    Electronic Resource
    Electronic Resource
    Improved Tissue Solubilization for Atomic Absorption. (1972)
    s.l. : American Chemical Society
    Analytical chemistry 44 (1972), S. 2081-2081 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac60320a001
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  • 2
    Electronic Resource
    Electronic Resource
    Photolysis of triphenylcarbonium, tropylium, and triphenylcyclopropenium ion (1968)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 90 (1968), S. 1372-1374 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja01007a061
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Testiculäre Feminisierung bei einem 5 Monate alten Kind, kombiniert mit familiärem, abnorm großem Y-Chromosom (1963)
    Springer
    Journal of molecular medicine 41 (1963), S. 690-694 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary A five months old apparently female child was examined because of inguinal hernia. Within both labial folds a palpable resistance was present which appeared at biopsy to be immature testes. Buccal mucosa smears were sex chromatin-negative. Chromosome analysis of leukocyte cultures showed a 46/XY constitution with an unusually long Y chromosome in all mitoses. Its length exceeds clearly that of the metacentrics of the 19–20 group and is comparable to that of chromosome No. 18. The diagnosis in this case was testicular feminization combined with a state of abnormally long Y chromosome. — Chromosome studies were performed also in the case of the father of this child. This study likewise revealed a similar long Y chromosome in all analysed metaphases. Thus a heritable variation of the length of the Y chromosome should be assumed. A causal relation of this finding to the condition of testicular feminization remains problematic; the coexistance of both conditions could be merely incidental.
    Notes: Zusammenfassung Ein etwa 5 Monate altes Kind von weiblichem Phänotyp zeigte eine Inguinalhernie und in beiden Labien palpable Resistenzen, die sich bei der Biopsie als Hoden erwiesen. Wangenschleimhautabstriche waren geschlechtschromatin-negativ. Eine Chromosomenuntersuchung an in vitro gezüchteten, aus Venenblut angereicherten Leukocyten ergab eine chromosomale Konstitution entsprechend 46/XY mit einem ungewöhnlich großen Y-Chromosom in allen untersuchten Mitosen. Die Länge dieses Y-Chromosoms überstieg deutlich diejenige der metazentrischen Chromosomen Nr. 19–20 und war vergleichbar mit derjenigen des Chromosoms Nr. 18. Es ergab sich daher die Diagnose einer testiculären Feminisierung, kombiniert mit einem abnorm langen Y-Chromosom. Eine Chromosomenuntersuchung von dem Vater dieses Kindes ergab ein gleichartiges ungewöhnlich großes Y-Chromosom in allen Zellen. Danach dürfte es sich um eine erbliche Größenvariation des Y-Chromosoms handeln. Eine ursächliche Beziehung dieses Befundes zu der testiculären Feminisierung bleibt noch ungewiß; es könnte sich auch um ein zufälliges Zusammentreffen handeln.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01478414
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  • 4
    Electronic Resource
    Electronic Resource
    Viability and gene expression in Chlamydia trachomatis during persistent infection of cultured human monocytes (1998)
    Springer
    Medical microbiology and immunology 187 (1998), S. 115-120 
    Details
    ISSN: 1432-1831
    Keywords: Key words Chlamydia ; Persistent infection ; Monocytes ; Transcription
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The principal host cell for persistently infecting synovial Chlamydia trachomatis is the macrophage. During infection of human monocytes/macrophages in culture this bacterium displays aberrant morphology and produces no new elementary bodies, reflecting the situation in synovium. Here we investigate the metabolic status of C. trachomatis (serovar K) during an extended infection of human peripheral monocytes in vitro. Using reverse transcription-polymerase chain reaction assays, we have shown that primary transcripts from the chlamydial rRNA operons are present throughout a 10-day course of infection. Other assays targeting mRNAs from chlamydial genes encoding r-proteins S5 and L5, the glycyl-tRNA synthetase, the 60-kDa cysteine-rich outer membrane protein, and the KDO transferase indicate that these messengers are also present throughout the entire 10-day period. The gene encoding the 57-kDa heat-shock protein (hsp60) is expressed by the bacterium throughout the 10-day infection of cultured monocytes, but transcript levels from the gene encoding the major outer membrane protein (omp1) appear to be attenuated. Western analyses targeting these latter proteins confirm the presence of the hsp60 gene product, and the virtual absence of major outer membrane protein, in chlamydia-infected cultured human monocytes. Thus, during extended infection of human monocytes in vitro, chlamydia are non-productive but transcriptionally active; the pattern of transcriptional activity reflects that known for persistent C. trachomatis infection in vivo in synovial tissue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004300050082
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  • 5
    Electronic Resource
    Electronic Resource
    Goldenhar, Möbius and hypoglossia-hypodactyly anomalies in a patient: syndrome or association? (1996)
    Springer
    European journal of pediatrics 155 (1996), S. 385-389 
    Details
    ISSN: 1432-1076
    Keywords: Key words Goldenhar ; Möbius ; Hypoglossia-hypodactyly ; Vascular ; disruption sequences
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The Möbius, Goldenhar and hypoglossia-hypodactyly anomalies are usually sporadic conditions with a recurrence risk of about 2%. The combination of Goldenhar and one of the two others is rare, whereas the concomitant occurrence of Möbius and hypoglossia-hypodactyly, and/or Poland, and/or Klippel-Feil anomaly is well known. Pathogenetically, vascular disruptions around the 4th embryonic week have been hypothesized. In vivo and pathological studies as well as animal models support this theory for all the above-mentioned combinations. Whether a preceding blastogenetic alteration is an influencing factor or a disorganization mutation, remains unclear. We describe a 3-year-old girl with bilateral anotia, epidermoid on the right eye, 6th and 7th nerve palsy, hypoglossia, left hypodactyly, and ventricular septal defect. Conclusion We wish to emphasize the aetiological relevance of vascular disruptions in this previously unreported combination of Möbius, Goldenhar and hypoglossia-hypodactyly anomalies. The concurrence of anomalies in this patient represents an association and not a pleiotropic syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01955267
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  • 6
    Electronic Resource
    Electronic Resource
    Respiratory effects and tolerability of Mr 2264 Cl (1994)
    Springer
    European journal of clinical pharmacology 46 (1994), S. 301-304 
    Details
    ISSN: 1432-1041
    Keywords: Respiratory depression ; Opiates ; Mr 2264 Cl ; ventilation ; morphine ; analgesics ; tolerability ; adverse events
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract In this double-blind, randomised, placebo-controlled cross-over study the respiratory effects of Mr 2264 Cl2 × 5 mg IV, a new partial opiate receptor agonist, were investigated and compared with the respiratory effects of morphine 2 × 10 mg IV and placebo. As primary end-points, the slope of the rebreathing curve (dV'/dPCO2ET) and V55 (ventilation at PCO2ET=55 mm Hg) were determined by Read's rebreathing method. The incidence of adverse events was also documented and compared. The respiratory depression after the intravenous administration of 5 mg and 10 mg Mr 2264 Cl was comparable to the decreased sensitivity of the respiratory centre after the 20 mg morphine IV. In contrast to morphine, a ceiling effect of Mr 2264 Cl was found. The tolerability of Mr 2264 Cl was comparable to that of morphine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00194395
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Goldenhar, Möbius and hypoglossia-hypodactyly anomalies in a patient: Syndrome or association? (1996)
    Springer
    European journal of pediatrics 155 (1996), S. 385-389 
    Details
    ISSN: 1432-1076
    Keywords: Goldenhar ; Möbius ; Hypoglossia-hypodactyly ; Vascular disruption sequences
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The Möbius, Goldenhar and hypoglossia-hypodactyly anomalies are usually sporadic conditions with a recurrence risk of about 2%. The combination of Goldenhar and one of the two others is rare, whereas the concomitant occurrence of Möbius and hypoglossia-hypodactyly, and/or Poland, and/or Klippel-Feil anomaly is well known. Pathogenetically, vascular disruptions around the 4th embryonic week have been hypothesized. In vivo and pathological studies as well as animal models support this theory for all the abovementioned combinations. Whether a preceding blastogenetic alteration is an influencing factor or a disorganization mutation, remains unclear. We describe a 3-year-old girl with bilateral anotia, epidermoid on the right eye, 6th and 7th nerve palsy, hypoglossia, left hypodactyly, and ventricular septal defect. Conclusion We wish to emphasize the aetiological relevance of vascular disruptions in this previously unreported combination of Möbius, Goldenhar and hypoglossia-hypodactyly of anomalies in this patient represents an association and not a pleiotropic syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01955267
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Focusing in sputtering
    Amsterdam : Elsevier
    Physics Letters A 40 (1972), S. 231-232 
    Details
    ISSN: 0375-9601
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0375-9601(72)90669-X
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Effect of apomorphine on retention of a brightness discrimination in dopamine supersensitive rats
    Amsterdam : Elsevier
    Behavioral and Neural Biology 41 (1984), S. 23-29 
    Details
    ISSN: 0163-1047
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Psychology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0163-1047(84)90680-0
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    High-speed metal-semiconductor-metal waveguide photodetector on InP (1989)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 55 (1989), S. 2173-2175 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We demonstrate high-speed performance of InGaAs barrier-enhanced metal-semiconductor-metal (M-S-M) Schottky barrier photodetectors monolithically integrated with double-heterostructure InP/InGaAsP/InP waveguides. Pulse response widths of 77 ps are recorded, with an associated 3 dB power bandwidth of 1.7 GHz. Photodetectors acting as both "taps'' of the waveguided signal and as "terminal'' devices were fabricated. These detectors have application in receivers which are integrated with semiconductor waveguides for on-chip optical signal processing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.102073
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