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  • 1
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of atenolol in hypertensive subjects with and without co-administration of chlorthalidone (1980)
    Springer
    European journal of clinical pharmacology 17 (1980), S. 333-337 
    Details
    ISSN: 1432-1041
    Keywords: atenolol ; chlorthalidone ; hypertension ; chronic treatment ; co-administration ; plasma half-life ; urine half-life
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of atenolol with and without the co-administration of chlorthalidone were studied in five hypertensive subjects. Concomitant administration of chlorthalidone appears to have little if any effect on the pharmacokinetics of atenolol during treatment for 7 days. The atenolol elimination half-lives were 6.7±1.1 and 6.3±0.9 h, respectively, with and without chlorthalidone. Two healthy volunteers also received a single 50 mg oral dose of chlorthalidone. Their blood profiles and pharmacokinetics were similar to those observed in hypertensive subjects, but a statistically significant difference (p〈0.01) was found between the urinary excretion half-lives of chlorthalidone. This difference may be because chronic administration of the drug caused saturation of red cell binding.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558445
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Beta-blockade antagonism of tyramine-induced rise in blood pressure (1988)
    Springer
    European journal of clinical pharmacology 34 (1988), S. 263-266 
    Details
    ISSN: 1432-1041
    Keywords: tyramine ; propranolol ; pressure response ; blood pressure ; beta-adrenoceptor blockers ; healthy volunteers ; indenolol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect β-adrenoceptor blockade on the pressor response to tyramine has been investigated in 6 healthy volunteers, each submitted to an i.v. tyramine pressor test before and after 7 days of propranolol 40 mg b.d. or indenolol 60 mg o.d. Tyramine was given as i.v. boluses of 1–6 mg, alternating with saline, in a randomized, single blind fashion. Prior to treatment tyramine caused a temporary, dose-dependent increase in systolic and diastolic blood pressure, whilst the heart rate remained unaffected. Both propranolol and indenolol reduced the pressor response to tyramine, as shown by a significant increase in ED15, i.e. the dose of tyramine required to increase systolic blood pressure by 15%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00540953
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Y1Ba2Cu3O6+δ growth on thin Y-enhanced SiO2 buffer layers on silicon (1991)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 59 (1991), S. 2323-2325 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: SiO2 buffer layers as thin as 2 nm have been developed for use in the growth of Y1Ba2Cu3O6+δ thin films on silicon substrates. The SiO2 layers are formed through Y enhancement of silicon oxidation, and are highly stoichiometric. Y1Ba2Cu3O6+δ film growth on silicon with thin buffer layers has shown c orientation and Tc0=78 K.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.106057
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    Paper (German National Licenses)
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