ISSN:
1572-882X
Keywords:
naftopidil
;
bufuralol
;
enantiomer separation
;
cellulose tris-(3,5-dimethylphenyl carbamate) chiral stationary phase
;
chiral recognition mechanism(s)
;
cellulose carbamates
Source:
Springer Online Journal Archives 1860-2000
Topics:
Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
,
Process Engineering, Biotechnology, Nutrition Technology
Notes:
Abstract The liquid Chromatographic resolution of the racemic cardiovascular drugs naftopidil and bufuralol to their corresponding enantiomers was achieved on cellulose tris-(3,5-dimethylphenyl carbamate) chiral stationary phase known as Chiralcel OD. The chiral recognition mechanism(s) involved between the chiral stationary phase and these drugs, which include hydrogen bonding, intercalative interactions, and steric interactions, among other factors, were discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00813019
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