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  • 1
    ISSN: 1432-1041
    Keywords: Key words Oxycodone ; Morphine ; Controlled-release formulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objective: The relative analgesic potency of single doses of oral controlled-release oxycodone and oral controlled-release morphine were compared in a randomized, double-blind trial using a postoperative pain model. Methods: Women (n = 169) with moderate to severe pain following abdominal hysterectomy received single oral doses of controlled-release oxycodone, 20 mg or 40 mg, or controlled-release morphine, 45 mg or 90 mg. Assessments were made at 30 min, 60 min, then hourly after dosing for 12 h or until remedication. Results: The most precise estimates of relative potency showed that controlled-release oxycodone was 1.8 times more potent than controlled-release morphine for total effect (95% confidence limits 1.09–2.42; lambda 0.44) and 2.2 times more potent for peak effect (95% confidence limits 0.96–4.59; lambda 0.71). Controlled-release oxycodone at doses of 20 mg or 40 mg was comparable with controlled-release morphine at doses of 45 mg or 90 mg, respectively, for total and peak analgesic effects. For the two higher doses, time to peak relief was approximately 1 h shorter with controlled-release oxycodone than with controlled-release morphine. Most patients reported onset of analgesia within 1 h with all doses. Side effects were similar with the two opioids. Conclusion: Oral controlled-release oxycodone was twice as potent as oral controlled-release morphine in this single-dose, relative potency assay. When converting patients from oral morphine to oral oxycodone, an initial oral oxycodone dose of one-half the oral morphine dose is recommended.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 95 (1991), S. 2882-2889 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The oxygen adsorption site on the Ir{110}-c(2×2)-O surface has been studied by time-of-flight scattering and recoiling spectrometry (TOF-SARS) using 4 keV Ne+ for backscattering and Ar+ for recoiling. The oxygen site was analyzed from scans of (i) backscattering intensity versus incident angle, (ii) oxygen recoil intensity versus incident and azimuthal angle, and (iii) oxygen recoil energy versus azimuthal angle. Calibrated shadow cones and trajectory simulations were used to obtain the site coordinates. This TOF-SARS data is contrasted with that of Ni{110}-p(2×1)-O, in which it is well established that the adsorption site is in the long-bridge position along the 〈001〉 rows. Adsorption of oxygen in the short-bridge sites above the 〈11¯0〉 Ir rows is the only model consistent with all of the experimental data and simulations. The O–Ir bond length is estimated to be ≈1.8 A(ring).
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 86 (1987), S. 2403-2410 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Time-of-flight (TOF) spectra of the scattered and recoiled particles resulting from 1–10 keV He+, Ne+, Ar+, Kr+, and Xe+ ions impingent on surfaces of LiF thin films have been obtained. Measurements of directly recoiled (DR) neutrals plus ions and neutrals alone are used to calculate positive and negative ion fractions Y+,− from DR events. The oppositely charged ion fractions have a distinctly different behavior as a function of kinetic energy. The Y+ values exhibit a threshold at low energy followed by a plateau region at higher energy while the Y− values are maximum in the low energy region followed by a decreasing yield as energy increases. The energy dependence of Y+,− is interpreted in terms of the recently developed model [J. Chem. Phys. 85, 3615 (1986)] for electronic charge exchange in keV ion/surface collisions which considers electron promotions in the close atomic encounter and resonant and Auger transitions along the outgoing trajectory. The ionization potential of the primary ion relative to the energy levels of the target atom is shown to have a large influence on charge exchange in the close encounter. The ratio of direct recoil to scattering particle flux increases by a factor of 〉102 from He to Xe; scattering and recoil cross sections are used to model this process.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Molecular and Cellular Probes 8 (1994), S. 481-486 
    ISSN: 0890-8508
    Keywords: astrovirus, polymerase chain reaction, viral diarrhoea
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Free Radical Biology and Medicine 15 (1993), S. 57-67 
    ISSN: 0891-5849
    Keywords: Free radicals ; Glutathione ; Oxidative stress ; Quinone ; γ-Glutamyl transpeptidase
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Free Radical Biology and Medicine 15 (1993), S. 543 
    ISSN: 0891-5849
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 52 (1989), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract Under conditions minimizing the contribution of Na+/Ca2+ exchange to calcium entry in synaptosomes, the K+ depolarization-dependent calcium influx (JCa) is a single exponential function of time. JCa activates and slowly inactivates at membrane potentials positive to –50 mV, a result indicating the involvement of moderate voltage-activating, slowly inactivating calcium channels. Calcium channels in synaptosomes are characterized by stronger sensitivity to blockage by Cd2+ than Co2+, insensitivity to dihydropyridine calcium antagonists or the agonist Bay K 8644, and weak, partial sensitivity to the peptide toxin ω-conotoxin GVIA. These characteristics suggest that voltage-sensitive calcium channels in rat cerebrocortical synaptosomes are dissimilar from the somatic T, N, or L channel types. JCa is not affected by treatment of synaptosomes with the adenylate cyclase activator forskolin, the membrane permeant dibutyryl-cyclic AMP, or the kinase C activator phorbol 12-myristate 13-acetate diester, results suggesting that calcium channels in synaptosomes are not directly modulated by protein kinase A- or C-mediated phosphorylation.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 61 (1990), S. 740-752 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A UHV spectrometer system has been designed and constructed for time-of-flight scattering and recoiling spectrometry (TOF-SARS). The technique uses a pulsed primary ion beam and TOF methods for analysis of both scattered and recoiled neutrals (N) and ions (I) simultaneously with continuous scattering angle variation over a flight path of ≈1 m. The pulsed ion beam line uses an electron impact ionization source with acceleration up to 5 keV; pulse widths down to 20 ns with average current densities of 0.05–5.0 nA/mm2 have been obtained. Typical current densities used herein are ≈0.1 nA/mm2 and TOF spectra can be collected with a total ion dose of 〈10−3 ions/surface atom. A channel electron multiplier detector, which is sensitive to both ions and fast neutrals, is mounted on a long tube connected to a precision rotary motion feedthru, allowing continuous rotation over a scattering angular range 0°〈θ〈165°. The sample is mounted on a precision manipulator, allowing azimuthal δ and incident α angle rotation, as well as translation along three orthogonal axes. The system also accommodates standard surface analysis instrumentation for LEED, AES, XPS, and UPS. The capabilities of the system are demonstrated by the following examples: (A) TOF spectra versus scattering angle θ; (B) comparison to LEED and AES; (C) surface and adsorbate structure determinations; (D) monitoring surface roughness; (E) surface semichanneling measurements; (F) measurements of scattered ion fractions; and (G) ion induced Auger electron emission.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 66 (1995), S. 3819-3825 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: In a hybrid slow positron beam, extraction of the positrons from the magnetic field (∼1 T for the PSI beam) to field-free space is a necessary operation. A theoretical and experimental demonstration is given which shows that the following proposed beam extraction method works as predicted: magnetic transport of the slow positrons down to field strengths of ∼100 G and passage through an aperture grid of ∼10 cm diameter in a field termination shield followed by some brightness enhancement stages. The simulation and measurement of the magnetic-field distributions along the beam axis show a steep drop down of the field from ∼100 G to a few gauss within 1 cm of shield thickness and a quasiuniform spreading of the transverse field strength across the grid opening. Measurement of transmission and divergency (transverse energy) of the beam exiting the extraction aperture confirmed theoretical estimations and ray tracing calculations for the aperture design used to be of the order of 75% and 20 eV, respectively. These data as a function of field strength and beam energy are used for optimization of the final extraction aperture design ((approximately-greater-than)85% transmission) to be used in the PSI high intensity beam facility. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 74 (1999), S. 3642-3644 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We report the synthesis of dense and uniform arrays of well-aligned carbon nanotubes on titanium substrates over large areas, in which all the tubes are simultaneously and completely filled with single crystals of titanium carbide. The carbon nanotubes were synthesized by thermal chemical vapor deposition of ethylene on iron-coated substrates, while the titanium carbide was simultaneously formed inside the nanotubes through a simultaneous solid state reaction. We propose a base dissolution and precipitation mechanism for the growth of titanium carbide filled carbon nanotubes. The same method can be used to fabricate oriented nanotube arrays filled with other carbides on a variety of substrates over large scale. Such well-aligned and densely packed uniform carbon nanotubes, completely filled with nanowires on conducting substrates, will have great potential in many applications. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
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