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  • 1
    Electronic Resource
    Electronic Resource
    Eearly Bone Repair and Regeneration of Nano-Sized ß-Tricalcium Phosphates/Collagen Composite in Rabbits (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 330-332 (Feb. 2007), p. 397-400 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: A novel biomimetic composite consisted of nano β-tricalcium phosphate and collagen(n-TCP/Col.), having similar structure with the natural bone, was produced by a wet-chemicalmethod. The biological effect with and without n-TCP/Col on bone repair and regeneration wasevaluated by histological and radiological examination in a rabbit femoral condyle model. Theresults showed that radiopacity of implant decreased gradually and began to increase at 12 weeks,while no obvious changes for the control. Histological results revealed that trabecular bone formedaround the implant at 4 weeks and increased at 8 weeks; By 12 weeks, bone filling with Harvard’ssystem was observed around the implant. By contrast, only loose connective tissue was seen incontrol group. This was further illuminated by fluorescence microscopy. The results of this studysuggested that the novel nano β-tricalcium phosphate and collagen composite possessed goodproperties of osteoconductivity and degradation in the biological environment, which could havepotential application as a promising bone substitute
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/52/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.330-332.397.pdf
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  • 2
    Electronic Resource
    Electronic Resource
    In vitro Investigation of Mesenchymal Stem Cells with Nanophase PLGA/HA Composite (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 330-332 (Feb. 2007), p. 1153-1156 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Bone grafts have been used to fill bone defects caused by disease or trauma. The amount ofautografts is limited and allogenic bone grafts may transmit diseases and cause immune responses.Numerous materials have been proposed and used as scaffolds for bone tissue reconstruction. In thisstudy, we tested nanophase PLGA/HA composite with mesenchymal stem cells in vitro to examineits biological response and cellular activity. The nanophase composite was compared toconventional polystyrene on cytocompatibility by cell attachment, proliferation, alkalinephosphotase activity test and scanning electron microscopy (SEM) analysis. The resultsdemonstrated that human mesenchymal cells showed more cell attachment and higher cellproliferation rate when growing on nanophase PLGA/HA composite than those growing onpolystyrene alone. And the composite also promoted MSC cells differentiate to osteoblast cells ascompared with control. It was suggested that the combination of bone marrow mesenchymal cellswith artificial materials or differentiation factors may enhance bone formation and regeneration,nanophase PLGA/HA composite might therefore be a promising scaffold material for bone tissuesubstitute in clinical application
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/53/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.330-332.1153.pdf
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of Woven Fabric Biodegradable Polyglycolic Acid on Joint Resurfacing with Fresh Chondrocytes in a Rabbit Model (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 330-332 (Feb. 2007), p. 1197-1200 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: To evaluate the effectiveness of the cell-material in situ on joint resurfacing, a wovenfabric polyglycolic acid (PGA) treated with fresh chondrocytes was used for repairing cartilagedefects. Full-thickness defects were created in the weight-bearing surfaces of the femoralintercondylar fossa in a rabbit model. The defect was filled with and without PGA under surgicalcondition. Before implantation, chondrocytes were co-cultured with PGA for one day. The animalswere sacrificed at eight weeks after implantation and evaluated grossly and histological score.Morphological examination showed that for PGA/chondrocytes group, the repaired tissue appearedsimilar in color and texture to the surrounding articular surface. While for the untreated control, nocartilage-like tissue was observed at all defects, but connective fibrous tissue. Histological analysisrevealed neochondrogenesis and clusters of cartilage matrix with specific safranin-O staining for thePGA/cell group. The Gross and histological evaluation indicated a significantly higher score forPGA/cell group than for PGA and control group. These results suggest that the woven fabric PGAmay facilitate the formation of cartilage tissues by providing a biodegradable and good-handlevehicle for the delivery to and retention of organized cell matrix constructs in vivo site. It mighttherefore enhance neochondrogenesis because of the superior biodegradable and biocompatible ofPGA scaffold sheet, while the more suitable biological environment might sustain cell growth andin situ cell function, suggesting a promising candidate for functional tissue engineering of clinicalenvironment
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/53/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.330-332.1197.pdf
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    Paper (German National Licenses)
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