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  • 1
    Electronic Resource
    Electronic Resource
    Hyperthyroidism associated with papilloedema and pyramidal tract involvement (1987)
    Springer
    Journal of neurology 235 (1987), S. 62-63 
    Details
    ISSN: 1432-1459
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00314204
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  • 2
    Electronic Resource
    Electronic Resource
    Regeneration of bovine and octopus opsins in situ with natural and artificial retinals (1989)
    s.l. : American Chemical Society
    Biochemistry 28 (1989), S. 2732-2739 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00432a055
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Histopathogenesis of inflammatory linear verrucose epidermal naevus: histochemistry, immunohistochemistry and ultrastructure (1991)
    Springer
    Archives of dermatological research 283 (1991), S. 491-499 
    Details
    ISSN: 1432-069X
    Keywords: Inflammatory linear epidermal naevus ; Keratinization ; DACM ; Involucrin ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Skin lesions of three patients with inflammatory linear verrucose epidermal naevus (ILVEN) were examined. Histologically, orthokeratosis and parakeratosis were alternately seen in the acanthotic epidermis. By N-(7-dimethylamino-4-methyl-3-coumarinyl)maleimide staining, the horny cells in the parakeratotic epidermis showed a cytoplasmic SH pattern and a weak membranous SS pattern. The orthokeratotic epidermis revealed an increased involucrin expression, whereas the parakeratotic epidermis showed almost no involucrin expression. Ultrastructurally, in the parakeratotic epidermis, the living keratinocytes had prominent Golgi apparatuses and vesicles in the cytoplasm. In the intercellular spaces in the upper spinous layer through to the lower horny layer, an electron dense, homogeneous substance was deposited. The cytoplasm of the horny cells was filled with keratin filaments and contained remnants of nucleus and cytoplasmic membrane structures, and some lipid droplets. The marginal band formation was incomplete. Most of these ultrastructural abnormalities were not found in the orthokeratotic epidermis. There are both similarities and differences in histopathogenesis of the parakeratotic epidermis between ILVEN and psoriasis. A unique finding was the lack of involucrin expression in the ILVEN parakeratotic epidermis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00371921
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  • 4
    Electronic Resource
    Electronic Resource
    Development of spinal motoneuron innervation of the upper limb muscle in the rat (1979)
    Springer
    Experimental brain research 35 (1979), S. 287-293 
    Details
    ISSN: 1432-1106
    Keywords: Bilateral motoneuron innervation ; Age-dependent decrease of motoneuron ; Rat spinal cord ; Horseradish peroxidase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Horseradish peroxidase was injected into the biceps brachii muscle of rats at various stages of development, from 10 days to 50 weeks. The retrogradely labeled neurons were found in the ipsilateral ventro-lateral column of the cervical cord, C4–C8, of all stages studied, but the number of labeled neurons decreased according to exponential curve as the age advanced. A striking finding was that the contralateral ventral horn cells were also labeled in the 10- and 14-day-old rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00236616
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  • 5
    Electronic Resource
    Electronic Resource
    Noradrenaline innervation of the spinal cord studied by the horseradish peroxidase method combined with monoamine oxidase staining (1977)
    Springer
    Experimental brain research 30 (1977), S. 175-186 
    Details
    ISSN: 1432-1106
    Keywords: Central noradrenergic innervation ; Rat spinal cord ; Horseradish peroxidase ; Monoamine oxidase staining
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The origin of the spinal cord noradrenaline (NA) has been investigated by means of the horseradish peroxidase (HRP) method, combined with monoamine oxidase staining (Glenner) to identify the NA neurons. Following the injection of HRP to the various levels of rat spinal cord, cervical to sacral cord, A1–3, 5–7 NA neuron groups were labeled with HRP. They showed almost the same distribution pattern regardless of difference in the injected segment. Labeled NA neurons in A6 were concentrated in the ventral division of the locus coeruleus, which continued to the labeled NA neurons in the subcoeruleus area. The HRP positive neurons in the pons outnumbered those of the medulla oblongata. As the NA neurons described above were considered to be the source of NA in the forebrain, such as the hypothalamus and preoptic area, the possibility that the same NA neurons might innervate both the forebrain and spinal cord has been presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00237249
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  • 6
    Electronic Resource
    Electronic Resource
    The fine structural organization of the locus coeruleus in the rat with reference to noradrenaline contents (1979)
    Springer
    Experimental brain research 37 (1979), S. 139-148 
    Details
    ISSN: 1432-1106
    Keywords: Locus coeruleus ; Noradrenaline granules ; Glyoxylic acid ; Permanganate fixation ; Dendro-dendritic contacts
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Combination of glyoxylic acid perfusion and postfixation in permanganate was used in an electron microscopic study of the locus coeruleus (LC) of the rat to give good preservation of fine structure and a reproducible demonstration of noradrenaline (NA) storage granules. Medium-sized LC cells (18 × 30 μm) contained a moderate number of small granular vesicles (SGV) and a few large granular vesicles (LGV), mainly near the Golgi apparatus. Dendritic branches were identified by their SGV content up to the tip. Dendrites were occasionally in close contact with each other or with the soma of LC cells, forming dendro-dendritic or dendro-somatic contacts. Numerous axon terminals containing many SGV and some LGV were observed in the neuropil, and they tended to contact dendrites and somata of LC cells or dendrites of unknown origin. These neuronal contacts were devoid of synaptic specializations except for an array of dense perpendicular lines between the juxtaposed membranes. Small oval cells (10 × 15 μm) devoid of SGV occurred frequently in the peripheral part of the nucleus, and they were occasionally in direct contact with LC cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01474260
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Demonstration of nigro-neostriatal tract by degeneration silver method (1973)
    Springer
    Experimental brain research 17 (1973), S. 133-138 
    Details
    ISSN: 1432-1106
    Keywords: Nigro-neostriatal tract ; Rat ; Survival time ; Fink-Heimer method ; Terminal degeneration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In the morphological demonstration of the nigro-neostriatal tract, there might be some discrepancies between the results by the histofluorescence method and by the degeneration silver method. The present investigation was undertaken to fill the gap by using the modified Nauta Method (Fink-Heimer) to rats surviving for varying periods after unilateral destruction of the substantia nigra. With survival time of 2–3 days, the Fink-Heimer method could demonstrate evenly and densely distributed argyrophilic spheroidal granules in the ipsilateral caudate putamen. These degenerating granules might represent the terminal degeneration of the nigro-neostriatal tract and probably correspond to the result by the histofluorescence method. From 4 days on the terminal degeneration rapidly decreased in amounts or disappeared, leaving a moderate number of beaded coarse fibers, which remained till 2 weeks. The result indicates the possibilities that the degeneration silver method could also be applicable to the demonstration of amine fibers by choosing staining condition and survival time optimal to each animal species and fiber tract.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00235022
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  • 8
    Electronic Resource
    Electronic Resource
    Demonstration by degeneration silver method of the ascending projection from the locus ceruleus (1974)
    Springer
    Experimental brain research 20 (1974), S. 181-192 
    Details
    ISSN: 1432-1106
    Keywords: Locus ceruleus ; Cerulo-cortical tract ; Ascending reticular fiber ; Rat ; Fink-Heimer method
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In order to demonstrate the ascending projection from the locus ceruleus by degeneration silver method, the nucleus was destroyed unilaterally in rats and the brains were stained by a modified Fink-Heimer method following various survival times. Additional experiments included the bilateral destruction of the locus ceruleus and the administration of 6-OH-DOPA. For the demonstration of degenerated terminals in the cerebral cortex it is essential to choose an optimal survival time of 4 or 5 days, keep the time of fixation below 1 week, and perform treatments with permanganate and with silver at 37°C. The trajectory and distribution of the cerulo-cortical tract as revealed by the silver degeneration methods is in agreement with the results of the histofluorescence method, with some minor differences. The ascending fibers run through Forel's tegmental fascicle, turn rostro-ventrally to the subthalamus, enter and cross the internal capsule, pass through the ventral part of the caudate-putamen and distribute to the entire cerebral cortex. The tract is mainly ipsilateral, though some fibers are crossing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00234012
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  • 9
    Electronic Resource
    Electronic Resource
    Afferent fiber connections from lower brain stem to hypothalamus studied by the horseradish peroxidase method with special reference to noradrenaline innervation (1978)
    Springer
    Experimental brain research 31 (1978), S. 81-94 
    Details
    ISSN: 1432-1106
    Keywords: Afferent connection ; Lower brain stem ; Hypothalamus ; Horseradish peroxidase ; Histofluorescence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Attempts were made to determine the afferent projections to the anterior hypothalamus including the preoptic area from the lower brain stem by means of the horseradish peroxidase method combined with monoamine oxidase staining to identify noradrenaline (NA) neurons. In addition to this technique, a histofluorescence analysis was performed. NA fibers in the medial part of the anterior hypothalamus were mainly supplied by A1 and A2 NA neuron groups, while the lateral part and periventricular zone received NA terminals from both pontine and medulla oblongata NA neuron groups. Furthermore, the present study indicated that there were direct projections to the anterior hypothalamus from non-noradrenergic neurons in the lower brain stem: nuclei raphe dorsalis, centralis superior, cells in the mesencephalic and pontine central gray matter, nuclei parabrachialis lateralis and medialis, cells around fasciculus longitudinalis medialis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00235806
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  • 10
    Electronic Resource
    Electronic Resource
    Ascending and descending components of the medial forebrain bundle in the rat as demonstrated by the horseradish peroxidase-blue reaction (1980)
    Springer
    Experimental brain research 39 (1980), S. 377-388 
    Details
    ISSN: 1432-1106
    Keywords: Medial forebrain bundle ; Ascending components ; Descending components ; HRP ; Sensitive substrate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The ascending and descending components of the medial forebrain bundle (MFB) were investigated by means of horseradish peroxidase (HRP) with a sensitive substrate. The HRP was injected iontophoretically into the MFB at various levels from the anterior commissure to the posterior hypothalamus. In order to prevent the diffusion of HRP to other brain areas, a double micropipette system was used. The descending components of the MFB are derived from (1) the anterior cingulate area, infra- or prelimbic area, and sulcal cortex, (2) the lateral septal nucleus and diagonal band, (3) the bed nucleus of the stria terminalis, (4) the paraventricular nucleus (5) the substantia innominata, (6) the amygdaloid complex (AM), (7) the ventromedial (VM) and dorsomedial (DM) hypothalamic nuclei, (8) the entopeduncular nucleus and (9) nucleus periventricularis stellatocellularis. The ascending components of the MFB originate in: (1) the medial preoptic nucleus, (2) the nucleus periventricularis stellatocellularis and rotundocellularis, (3) the posterior hypothalamic nucleus, (4) the parafascicular nucleus, (5) the ventral premammillary nucleus, (6) the substantia grisea periventricularis, (7) the lateral habenular nucleus, (8) the VM and DM, (9) the paratenial nucleus, (10) the AM and (11) the arcuate nucleus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00239302
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