ISSN:
1432-1432
Keywords:
Key words: Prebiotic synthesis —α-Oligoribonucleotide —α- and β-RNA — Uranyl-ion catalysis — Template-directed synthesis — Stacking and conformational properties — Selective advantage
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract. Oligomerization of α-adenosine 5′-phosphorimidazolide (α-ImpA) has been done in an aqueous solution using a uranyl-ion catalyst or a poly(U) template as a model process of prebiotic synthesis of RNA with α-glycosidic linkage. α-Oligoriboadenylates up to hexamer were formed from α-ImpA by the uranyl-ion catalyst. 3′-5′ Linkage was mainly formed in the oligomerization. The poly(U) template mediated the oligomerization of α-ImpA, but to a very low extent. The yield and chain length of the resulting α-oligomers were far lower than those of the corresponding β-oligomer formation under the same conditions. Physico-chemical properties of α-oligoriboadenylates are presented along with those of the corresponding β-oligoriboadenylates. The results indicate that β-RNA is more advantageous than α-RNA from the points of their synthesis and properties.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/PL00006222
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