ISSN:
1432-1076
Keywords:
Key words Insulin-like growth factor
;
Insulin-like growth factor binding protein 3
;
Growth hormone deficiency
;
mesenteric cyst
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract A 12.5-year-old girl presented with short stature. Insulin-like growth factor 1(IGF-I) and insulin- like growth factor binding protein (IGFBP-3) were below the 0.1 percentile. Growth hormone provocation tests disclosed normal responses to l-arginine and insulin-induced hypoglycaemia. A huge benign mesenteric cyst was discovered by abdominal ultrasound and completely removed. Subsequently, the girl showed a marked catch-up growth; however, IGF-I and IGFBP-3 remained below the 0.1 percentile. Conclusion These observations imply that growth may take place even with very low levels of insulin-like growth factors. The interpretation of low IGF-I and IGFBP-3 levels in short children still requires good clinical judgement and basic knowledge of their biological action.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s004310050920
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