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  • 1
    ISSN: 1432-0428
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 499 (1987), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Psychopharmacology 74 (1981), S. 353-354 
    ISSN: 1432-2072
    Keywords: Naloxone ; Mental testing ; Self-ratings ; Sedation ; Normal subjects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of single intravenous doses of naloxone (0.8 and 1.6 mg) in a variety of performance tasks and on subjective ratings of mood and bodily symptoms were investigated in 12 student volunteers. Naloxone was without effect on any of the performance measures. However, 5 min after naloxone (1.6 mg) the subjects felt significantly more troubled, mentally slow, incompetent, withdrawn and physically tired, and less irritable. These effects appeared to be dose-related since 0.8 mg produced similar, but not statistically significant changes. Sixty-five minutes after the higher dose subjects felt significantly more muzzy and incompetent: in contrast to the effects at 5 min they now felt significantly more irritable. These results are difficult to explain solely in terms of opiate receptor blockade.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-2072
    Keywords: Dexamphetamine ; Visual analogue scale ; Hunger ; Arousal ; Mood
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of dexamphetamine (d-Amp) and placebo on visual analogue scale (VAS) ratings of hunger, arousal and mood in nine male volunteers was observed. d-Amp (10 mg) significantly depressed hunger ratings but did not significantly affect arousal and mood ratings. d-Amp (20 mg) had a significant effect on all three ratings. There was a difference in the pattern of dose-response effects. Whereas 20 mg d-Amp produced greater changes than 10 mg in ratings of mood and arousal, there was no significant difference on ratings of hunger. These differences in dose-response relationships may reflect differences in the underlying neurochemical mechanisms mediating the stimulant and anorectic effects of d-Amp.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Psychopharmacology 25 (1972), S. 315-320 
    ISSN: 1432-2072
    Keywords: Phentermine ; Appetite ; Food Intake ; Obesity ; Weight Reduction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The anorectic effects of phentermine resinate (Duromine) in doses of 15 mg and 30 mg were compared to placebo under double-blind, controlled conditions in six moderately overweight but otherwise healthy women aged 24 to 48. The relative changes in hunger produced by each of the three preparations over a period of 10 h were determined by using a visual analogue hunger scale. In addition the effect of each on calorie intake 5 h and 10 h after administration was measured. Both 15 mg and 30 mg phentermine had a significant effect on calorie intake, the dosage of 15 mg reducing calorie intake by 25%, and 30 mg by 33% over the 10 h observation period. There were corresponding changes in hunger rating observed, with a correlation of +0.68 between hunger rating and calorie intake being found. On the basis of these results it is concluded that phentermine, in doses of 15 mg and 30 mg, does have a direct appetite suppressant action.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-2072
    Keywords: Amphetamine ; Hunger ; Mood ; Arousal
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In rats, low doses of d-amphetamine (d-amp) increase rather than decrease food intake. A doubleblind study was carried out in nine healthy female subjects to compare the effects of a low (1 mg) and a moderate (10 mg) dose of d-amp and placebo on hunger, mood and arousal. Each subject participated in three experimental sessions, 1 week apart, when they received either 1 mg d-amp, 10 mg d-amp or placebo, according to a random double-blind design. Visual analogue rating scales for hunger, mood and arousal were completed prior to drug administration and at 30-min intervals for 4 h. A questionnaire relating to sleep pattern and side effects was completed the morning after each experimental session. d-Amp (10 mg) produced a significant reduction in hunger ratings as compared with placebo at 2 h and 2.5 h after administration, while 1 mg d-amp had no significant effect on hunger. Mood and arousal were only slightly elevated by 10 mg d-amp, and not at all by 1 mg.
    Type of Medium: Electronic Resource
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