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  • 1
    Electronic Resource
    Electronic Resource
    Synthesis and Reactivity of New Mono(cyclopentadienyl)zirconium and -hafnium Alkyl Complexes. Crystal and Molecular Structure of [{C5H3(SiMe3)2}HfMe2(.eta.6-toluene)][BMe(C6F5)3] (1995)
    s.l. : American Chemical Society
    Organometallics 14 (1995), S. 2456-2462 
    Details
    ISSN: 1520-6041
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/om00005a049
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    A systematic approach to modeling, capturing, and disseminating proteomics experimental data (2003)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 21 (2003), S. 247-254 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Both the generation and the analysis of proteome data are becoming increasingly widespread, and the field of proteomics is moving incrementally toward high-throughput approaches. Techniques are also increasing in complexity as the relevant technologies evolve. A standard ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0303-247
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Charge densities from high-resolution synchrotron X-ray diffraction experiments (2000)
    Chester : International Union of Crystallography (IUCr)
    Journal of synchrotron radiation 7 (2000), S. 160-166 
    Details
    ISSN: 1600-5775
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Geosciences , Physics
    Notes: The combination of intense X-ray sources, especially synchrotron radiation, with area-detector technology has accomplished an enormous advance in the experimental conditions available for charge-density analysis by single-crystal high-resolution X-ray diffraction. Such experiments can now be carried out in a time measured in hours rather than weeks. Some features of these experiments are examined and preliminary results are reported for charge-density studies of 2-hydroxy-5-nitrobenzaldehyde N-cyclohexylimine (1), octakis(m-tolylthio)naphthalene (2), and 7-fluoro-4-styrylcoumarin (3). Weak interactions in crystals of (1) and (3) are found to have similar charge-density characteristics. Cages in the crystal lattice of (2) have a complex charge distribution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0909049500002958
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  • 4
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    In-situ defect detection in laser powder bed fusion by using thermography and optical tomography – comparison to computed tomography (2020)
    Details
    Publication Date: 2022-07-19
    Language: English
    Type: article , doc-type:article
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    OPUS
  • 5
    Electronic Resource
    Electronic Resource
    Kinetics and Physical Parameters of Rat Brain Opioid Receptors Solubilized by Digitonin and CHAPS (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 46 (1986), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Rat brain opioid receptors were solubilized with digitonin and a zwitterionic detergent, 3-[(3-cholamido-propyl)-dimethylammonio]-1-propanesulfonate (CHAPS). The yield of solubilization was 70–75% with digitonin and 30–35% with CHAPS. Kinetic and equilibrium studies performed from digitonin extracts resulted in KD values comparable with those of the membrane fractions. Two [3H]naloxone binding sites were obtained in the extracts similarly to membrane fractions. The rank order potency of drugs used in the competition experiments did not change during solubilization. The distributions of μ, δ, and κ opioid receptor binding sites were similar in membrane and digitonin-solubilized fractions (48–50%μ, 35–37%κ, and 13–17%δ subtypes). The hydrodynamic properties of digitonin- and CHAPS-solubilized preparations were studied by sucrose density gradient centrifugation and Sepharose-6B chromatography. In all cases, two receptor populations were identified with the following parameters: sedimentation coefficients for the digitonin extracts were 9.2S and 13.2S and for CHAPS extract 8S and 15.6S; the Stokes radii were 45Å and 65Å for the digitonin extract and 31Å and 76Å for the CHAPS-solubilized preparation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1986.tb13027.x
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Neurochemical Effects Following Peripheral Administration of Tetrahydropterin Derivatives to the hph-1 Mouse (1996)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 66 (1996), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The hph-1 mouse, which displays tetrahydrobiopterin deficiency and impaired dopamine and serotonin turnover, has been used to study cofactor replacement therapy for disorders causing brain tetrahydrobiopterin deficiency. Subcutaneous administration of 100 µmol/kg (30 mg/kg) of tetrahydrobiopterin resulted in a twofold increase in brain cofactor concentration 1 h after administration. Concentrations remained above the endogenous level for at least 4 h but returned to normal by 24 h. The lipophilic tetrahydrobiopterin analogue 6-methyltetrahydropterin entered the brain five times more efficiently than tetrahydrobiopterin but was cleared at a faster rate. Tetrahydropterins linked to the lipoidal carrier N-benzyl-1,4-dihydronicotinoyl did not result in a detectable increase in levels of brain pterins over the period of the study (1–4 h). Stimulation of monoamine turnover was not observed at any time point with either natural cofactor or the methyl analogue. Increasing the amount of tetrahydrobiopterin to 1,000 µmol/kg resulted in elevation of cofactor concentrations, a brief increase in the activity of tyrosine and tryptophan hydroxylase 1 h postadministration, and increased turnover of dopamine and serotonin metabolites lasting 24 h. However, 2 of 12 (17%) mice died following administration of this dose of cofactor. Our findings suggest that acute peripheral tetrahydrobiopterin administration is unlikely to stimulate brain monoamine turnover directly unless very large and potentially toxic doses of cofactor are used.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1996.66031150.x
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Effect of Peroxynitrite on the Mitochondrial Respiratory Chain: Differential Susceptibility of Neurones and Astrocytes in Primary Culture (1995)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 64 (1995), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The effect of the neurotoxic nitric oxide derivative, the peroxynitrite anion (ONOO−), on the activity of the mitochondrial respiratory chain complexes in cultured neurones and astrocytes was studied. A single exposure of the neurones to ONOO− (initial concentrations of 0.01–2.0 mM) caused, after a subsequent 24-h incubation, a dose-dependent decrease in succinate-cytochrome c reductase (60% at 0.5 mM) and in cytochrome c oxidase (52% at 0.5 mM) activities. NADH-ubiquinone-1 reductase was unaffected. In astrocytes, the activity of the mitochondrial complexes was not affected up to 2 mM ONOO−. Citrate synthase was unaffected in both cell types under all conditions studied. However, lactate dehydrogenase activity released to the culture medium was increased by ONOO− in a dose-dependent manner (40% at 0.5 mM ONOO−) from the neurones but not from the astrocytes. Neuronal glutathione concentration decreased by 39% at 0.1 mM ONOO−, but astrocytic glutathione was not affected up to 2 mM ONOO−. In isolated brain mitochondria, only succinate-cytochrome c reductase activity was affected (22% decrease at 1 mM ONOO−). We conclude that the acute exposure of ONOO− selectively damages neurones, whereas astrocytes remain unaffected. Intracellular glutathione appears to be an important factor for ameliorating ONOO−-mediated mitochondrial damage. This study supports the hypothesis that the neurotoxicity of nitric oxide is mediated through mitochondrial dysfunction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1995.64051965.x
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Age-Dependent Alterations in Dopamine Content, Tyrosine Hydroxylase Activity, and Dopamine Uptake in the Striatum of the Weaver Mutant Mouse (1994)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 62 (1994), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Mice of different ages and homozygous or heterozygous for the weaver gene (wv) were used to study the time course for the effect of the weaver gene on several striatal dopaminergic parameters. Dopamine uptake was decreased in the homozygous weaver at all ages examined. The deficit in uptake at the earliest age studied, postnatal day 3, was approximately 50% and increased to greater than 70% at older ages. In control mice, dopamine uptake reached a maximum by postnatal day 22, but in homozygous weaver mice, development of uptake activity was curtailed by postnatal day 7. Dopamine content and tyrosine hydroxylase activity were significantly decreased in the homozygous weaver at all ages studied except postnatal days 7 and 10. The magnitude of the deficit in dopamine content ranged from approximately 40% at postnatal days 3 and 5 to about 70% in adults (6 months to 1 year of age). The magnitude of the deficit in tyrosine hydroxylase activity ranged from 40 to 70%. In general, no major differences between heterozygotes and controls were observed for any of the dopaminergic parameters investigated. The results of the present investigation indicate that neurochemical alterations can be observed in the striata of weaver mice as early as postnatal day 3 and raise the possibility that the striatal dopamine transporter may be an early target of the weaver mutation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1994.62020543.x
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Monte Carlo simulation of F−(H2O)4 using an ab initio potential (1999)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 110 (1999), S. 4338-4346 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: We present results concerning the structure and energetics of the cluster F−(H2O)4 at 0 K, using high quality ab initio methods, and at a temperature of 300 K, using an ab initio Monte Carlo simulation. At 0 K, we find the global energy minimum corresponds to three waters solvating the fluoride ion and with the fourth water in an outer hydration shell, hydrogen bonding to the other water molecules. Structures involving four waters hydrogen bonding to the fluoride are, however, of only slightly higher energy. At 300 K, the simulation results indicate that the fluoride is mostly to be found within a tetrahedron of solvating water molecules. The cluster is mobile, however, and a wide variety of structures are sampled. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.478315
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    Double perturbation series in the differential equations of enzyme kinetics (1998)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 109 (1998), S. 411-423 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The connection between combined singular and ordinary perturbation methods and slow-manifold theory is discussed using the Michaelis-Menten model of enzyme catalysis as an example. This two-step mechanism is described by a planar system of ordinary differential equations (ODEs) with a fast transient and a slow "steady-state" decay mode. The systems of scaled nonlinear ODEs for this mechanism contain a singular (η) and an ordinary (cursive-epsilon) perturbation parameter: η multiplies the velocity component of the fast variable and dominates the fast-mode perturbation series; cursive-epsilon controls the decay toward equilibrium and dominates the slow-mode perturbation series. However, higher order terms in both series contain η and cursive-epsilon. Finite series expansions partially decouple the system of ODEs into fast-mode and slow-mode ODEs; infinite series expansions completely decouple these ODEs. Correspondingly, any slow-mode ODE approximately describes motion on M, the linelike slow manifold of the system, and in the infinite series limit this description is exact. Thus the perturbation treatment and the slow-manifold picture of the system are closely related. The functional equation for M is solved automatically with the manipulative language MAPLE. The formal η and cursive-epsilon single perturbation expansions for the slow mode yield the same double (η,cursive-epsilon) perturbation series expressions to given order. Generalizations of this procedure are discussed. © 1998 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.476578
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    Paper (German National Licenses)
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