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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 117 (1995), S. 2122-2122 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Current genetics 4 (1981), S. 205-214 
    ISSN: 1432-0983
    Keywords: Cellcycle ; Gl period ; cdc genes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Here we report the isolation of several new temperature-sensitive mutations which cause cells of the yeast Saccharomyces cerevisiae to arrest in the G1 period of the cell cycle. Four different selection schemes were employed. The cell division cycle (cdc) mutations define five new complementation groups. At non-permissive temperatures, strains bearing these new cdc mutations arrested in G1 within one cell division cycle. By order-of-function mapping, cells of each population were found to be arrested at “start”, the regulatory point in the G1 period of yeast. Mutations were grouped into two categories by the abilities of mutant strains to continue extensive macromolecular synthesis and to conjugate with cells of the opposite mating type. For strains with mutations in one category, shift to the non-permissive temperature caused an abrupt decrease in the rates of labelling of protein and RNA, and rendered cells unable to mate efficiently. For strains with mutations in the second category, cells continued to grow and mating ability was not significantly impaired. Each selection scheme was also designed to isolate mutations which specifically affect the ability of cells to reinitiate the cell cycle from stationary phase. This was done to test the hypothesis that stationary phase cells are in a unique developmental state referred to as G0. No mutations specific for resumption of growth from stationary phase were isolated.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 253 (1975), S. 650-651 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] To establish whether any controls at the level of gene expression have evolved in blue-green algae, it seems pertinent to look for responses to environmental stimuli which do affect the growth of these organisms. Such stimuli include CO2, sources of phosphorus and nitrogen, and, of course, light. ...
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Molecular genetics and genomics 176 (1979), S. 37-39 
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The addition of nalidixic acid to growing cells of the yeast Saccharomyces cerevisiae resulted in a transient depression in the rate of ribosomal precursor RNA production and a transient arrest of cells in G1. Protein synthesis rates were less affected. Lower concentrations of nalidixic acid also affected RNA synthesis and progression through G1 but had no effect on protein synthesis rates. We suggest that nalidixic acid has a primary effect on RNA synthesis leading to a G1 arrest.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Molecular genetics and genomics 178 (1980), S. 357-360 
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary When shifted from 23°C to 36°C, cells of a non-temperature-sensitive strain of yeast arrest transiently in G1 before continuation of the cell division cycle. When shifted to 36°C, cells harboring a temperature-sensitive rna mutation behave similarly. Others have shown that temperature shift transiently decreases the rates of production and processing of ribosomal precursor RNA (rpreRNA). Production of rpreRNA is soon restored to normal levels in these strains, but normal processing of these rpreRNA transcripts is restored only in non-temperature-sensitive strains. Therefore these experiments serve to eliminate from cell cycle considerations the involvement of processing of rpreRNA, while maintaining the established correlation between cell cycle behavior and rpreRNA production.
    Type of Medium: Electronic Resource
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