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  • 1
    ISSN: 1432-0428
    Keywords: Blood sugar response ; plasma insulin response ; serum cholesterol ; serum triglyceride ; atherosclerosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Les auteurs présentent leurs observations sur la fréquence du taux anormal de cholestérol et de triglycérides sériques et sur les réponses anormales du glucose sanguin et de l'insuline provoquées par le test de tolérance au glucose chez 51 patients de sexe masculin présentant des troubles athérosclérotiques des vaisseaux périphériques. La comparaison des résultats relevés dans ce groupe avec ceux d'un groupe de 47 témoins strictement comparables par l'âge et le sexe a été faite. Les deux groupes présentaient un même degré d'obésité. L'anomalie la plus fréquente était une réponse de l'insuline du plasma plus prolongée et plus prononcée. Cette réponse était beaucoup plus fréquente chez les athérosclérotiques que chez les sujets normaux. Plus de 75% des malades ont montré une anomalie du taux de glucose sanguin ou de la réponse de l'insuline. Une augmentation du taux des lipides sanguins à jeûn était beaucoup plus rare bien que le taux moyen de cholestérol sérique ait été nettement supérieur à celui des sujets témoins.
    Abstract: Zusammenfassung Die Autoren berichten über die Häufigkeit von Anomalien der Nüchternwerte von Serumcholesterin und Serumtriglyzeriden und über anormale Blutzucker- und Plasmainsulinreaktionen nach einem oralen Glucosebelastungstest bei 51 männlichen Patienten mit atherosklerotischen peripheren Gefäßkrankheiten. Sie verglichen diese Befunde mit 47 gesunden Personen in einer nach Alter und Geschlecht vergleichbaren Gruppe. Die beiden Gruppen wiesen einen ähnlichen Grad von Adipositas auf. Die häufigste Anomalie war eine verlängerte und erhöhte Plasmainsulinreaktion, die viel häufiger bei den Atherosklerotikern als bei den Kontrollen vorkam. Über 75% der Patienten zeigten anormale Blutzucker-oder Insulinreaktionen. Eine Erhöhung der Nnchtern-Serumlipidwerte trat viel seltener auf, obwohl die mittleren Serumcholesterinspiegel bei den Atherosklerotikern signifikant höher lagen als bei den Kontrollen.
    Notes: Summary The incidence of abnormalities of fasting serum cholesterol and triglyceride levels and blood sugar and plasma insulin response to an oral glucose load have been investigated in a group of 51 male patients with atherosclerotic peripheral vascular disease. These have been compared with an age and sex matched group of 47 healthy controls. Both groups showed a similar degree of obesity. The most common single abnormality was a prolonged and increased plasma insulin response, which was much more frequently seen among patients than controls. Over 75% of the patients showed abnormality of blood sugar or insulin response. Elevation of fasting levels of serum lipids was considerably less common, although the mean serum cholesterol level of the patients was significantly higher than that of the controls. The relevance of these results is discussed.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0428
    Keywords: Intrasplenic rat pancreas transplantation ; insulin ; glucagon ; adipose tissue
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Proliferation of adipose tissue adjacent to intrasplenic transplants of whole isogeneic neonatal rat pancreas has consistently been noted. In this study over a period of 18 months there was a progressive increase in the amount of fatty tissue in the vicinity of surviving transplants. Immunohistochemistry demonstrated the presence of insulin, glucagon, somatostatin and pancreatic polypeptide within islet cells in long term grafts. Electron microscopy demonstrated a close association between islets and lipid droplets. Ductal elements within the transplants survived and showed close association with endocrine cells, but exocrine pancreatic tissue degenerated rapidly. Radioimmunoassay of extracts from surviving transplants in isogeneic rats confirmed the presence of high levels of insulin and glucagon after transplantation. In contrast, allogeneic intrasplenic transplants of rat pancreas failed to survive and showed no evidence of adipose tissue proliferation. Furthermore, isogeneic intrasplenic transplants of both adult rat fat and adrenal gland also failed to demonstrate adipocyte proliferation. It would appear that the presence of both adipocytes and pancreatic endocrine cells, particularly B cells, are required for the proliferation of adipocytes at the graft site.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 12 (1988), S. 0 
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The clinical and histological findings in 15 cases of carcinoma arising from the extrahepatic biliary tract are reviewed. The clinical findings are in agreement with previously reported series and the dismal prognosis is confirmed. The prognosis does not appear to be related to tumour size, site, mitotic count or laboratory data on presentation. Only histological grading of the tumour is related to prognosis. Perineural tumour infiltration was a prominent feature and dysplasia within adjacent bile duct epithelium was present in five cases. The value of carcinoembryonic antigen (CEA) as a histological tumour marker was investigated. All tumours from the upper and middle biliary tree expressed this antigen. Although immunocytochemistry is seldom needed to assess malignancy in large surgical resection specimens anti-CEA helps delineate the extent of tumour infiltration and discriminates between normal and dysplastic or malignant epithelium; anti-CEA may also be helpful in identifying foci of malignancy in small sclerotic biopsy specimens.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 14 (1989), S. 0 
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Morphometric measurements of nuclear area, nuclear concentration and nucleolar dimensions in defined tissue zones of orientated oesophageal biopsy sections were compared between three patient groups–asymptomatic/normal endoscopy (n= 8): symptomatic reflux/normal endoscopy (n= 17); and symptomatic/endoscopic oesophagitis (n= 15). No significant differences could be shown for any mean parameter between clinical groups. In a further group of 16 patients, identical morphometric measurements were made in non-orientated grasp biopsies and correlated with prolonged ambulatory pH data. No significant correlations could be shown between nuclear parameters and acid reflux measurements. These results suggest that morphometric measurement cannot be recommended as a diagnostic tool in the diagnosis of oesophagitis, although it may be useful in the assessment of individual therapeutic response in clinical trials.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 67 (1996), S. 3599-3604 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A simple, reliable system for long-range translation of scanned probe microscopy (SPM) samples is described. This system could easily be retrofitted to many existing SPMs. The sample is held magnetically onto the scan piezo tube, and is translated by stick-slip motion. The system is very reliable, and provides controllable step size ranging from 20 nm to 1 μm. Three stick-slip drive wave forms are described and tested: sawtooth, cycloid, and an "improved'' cycloid based on the resonance curve of a harmonic oscillator. Computer simulations of the stick-slip process are presented, and are in good agreement with experiment. Together, the experiments and simulations demonstrate that it is essential to consider the resonant response of the piezo when evaluating drive wave forms. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Histochemistry and cell biology 90 (1988), S. 161-164 
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The nature of xenopsin immunoreactivity in mammalian antral G-cells has been reassessed. Xenopsin immunostaining was most intense in human antral G-cells, present in those of the dog and pig and not detected in guinea pig or rat tissues. Rigorous specificity controls for ionic binding of immunoglobulins to antral G-cell granules indicated that this mechanism was not responsible for xenopsin immunostaining. Preincubation of the xenopsin antiserum with xenopsin, human gastrin 1–13 and gastrin 2–17 completely abolished immunostaining at similar molar concentrations. Gastrin 34 was ineffective at much higher concentrations. These results infer that xenopsin-immunoreactivity in antral G-cells resides in the N-terminal region of gastrin 17. Examination of the primary structures of xenopsin and the N-terminal regions of some mammalian gastrins reveals a hitherto unrecognized homology.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1573-4986
    Keywords: extrahepatic biliary tract carcinoma ; gall bladder carcinoma ; T antigen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The mucin-associated antigens Tn, sialosyl-Tn (STn), T and sialosyl-T (STAg) antigens accumulate through aberrant and incomplete glycosylation in malignant epithelial cells. Their diagnostic and prognostic significance in tumours of the colon and cervix has been described, and a possible role for Tn antigen in cell-to-cell adhesion has been suggested. These antigens have been demonstrated through peanut agglutinin (PNA) lectin binding and more recently using specific monoclonal antisera. Differences between the two methods have been described, which may be due to fixation schedules and/or specificity. We have investigated the effect of fixation on the binding of biotinylated PNA lectin and compared its reactivity with the immunoreactivity of monoclonal antisera to Tn, STn, T and STAg antigens in benign and malignant epithelium of the gall bladder, extrahepatic bile ducts and ampulla of Vater. We found that short-term fixation in formol sublimate resulted in poor PNA binding. All other tested fixation schedules showed strong perinuclear binding, similar to that found on cryostat sections. When compared with monoclonal antisera, PNA binding demonstrated the lowest specificity in benign epithelium. In both benign and malignant epithelium, the two methods cannot substitute for each other. STn and STAg antigens were found to be oncodevelopmental throughout the extrahepatic biliary tract. When used in a panel, they are useful as diagnostic markers of malignancy in gall bladder epithelium.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part B: Polymer Physics 36 (1998), S. 337-344 
    ISSN: 0887-6266
    Keywords: infrared spectroscopy ; multicomponent ; diffusion ; polymer ; Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: In this study, diffusion coefficients of toluene/methyl ethyl ketone (MEK) mixtures in polyisobutylene were measured at 50°C using vapor sorption FTIR-ATR (Fourier Transform Infrared Attenuated Total Reflectance) spectroscopy. For three mixture compositions, the diffusion coefficients were determined using a diffusion framework for ternary systems. The “crossterm” diffusion coefficient for MEK was found to be very small under the experimental conditions studied here, while that for toluene was found to increase with increasing MEK concentration. On the basis of this finding, a binary diffusion model was used to determine diffusion coefficients for MEK over a wide range of mixture compositions and the results compared well with those determined from pure MEK transport data. Relative transport rates during integral sorption experiments with mixtures were used to explain the results. © 1998 John Wiley & Sons, Inc. J Polym Sci B: Polym Phys 36: 337-344, 1998
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part B: Polymer Physics 35 (1997), S. 1261-1267 
    ISSN: 0887-6266
    Keywords: FTIR-ATR spectroscopy ; gravimetric sorption ; diffusion ; polymer ; Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: In this study, vapor sorption FTIR-ATR (Fourier Transform Infrared Attenuated Total Reflectance) spectroscopy was combined with a conventional gravimetric sorption balance to examine diffusion in polymers. Mutual diffusion coefficients of methyl ethyl ketone in polyisobutylene were measured using both methods at various penetrant activities and temperatures in the range 40-60°C. Actual penetrant concentrations were determined from the sorption balance. The diffusion coefficients from the two techniques agree very well with each other. In addition, the diffusivity data from both techniques could be correlated successfully as a function of temperature and concentration with the Vrentas and Duda free-volume model. © 1997 John Wiley & Sons, Inc. J Polym Sci B: Polym Phys 35: 1261-1267, 1997
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
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