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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 86 (1993), S. 36-41 
    ISSN: 1432-0533
    Keywords: Alzheimer's disease ; β/A4 deposits ; Morphological types ; Spatial pattern ; Clustering
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The spatial patterns of diffuse, primitive, classic (cored) and compact (burnt-out) subtypes of β/A4 deposits were studied in coronal sections of the frontal lobe and hippocampus, including the adjacent gyri, in nine cases of Alzheimer's disease (AD). If the more mature deposits were derived from the diffuse deposits then there should be a close association between their spatial patterns in a brain region. In the majority of tissues examined, all deposit subtypes occurred in clusters which varied in dimension from 200 to 6400 μm. In many tissues, the clusters appeared to be regularly spaced parallel to the pia or alveus. The mean dimension of the primitive deposit clusters was greater than those of the diffuse, classic and compact types. In about 60% of cortical tissues examined, the clusters of primitive and diffuse deposits were not in phase, i.e. they alternated along the cortical strip. Clusters of classic deposits appeared to be distributed independently of the diffuse deposit clusters. Cluster size of the primitive deposits was positively correlated with the density of the primitive deposits in a tissue but no such relationship could be detected for the diffuse deposits. This study suggested that there was a complex relationship between the clusters of the different subtypes of β/A4 deposits. If the diffuse deposits do give rise to the primitive and classic varieties then factors unrelated to the initial deposition of β/A4 in the form of diffuse plaques were important in the formation of the mature deposits.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 217 (1968), S. 760-760 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Table 1 Experimental cage H.,O (ml.) D2O (ml, Control cage ,) H20 (ml.) H 2O (ml. 12-8 2-8 7-2 10-2 13-2 3-2 15-2 13-4 15-2 2-1 10-0 12-0 14-2 2-1 9-5 12-0 12-2 3-6 14-4 5-0 14-0 3-6 12-0 15-0 15-2 4-2 14-6 17-4 10-8 2-0 4-4 11-0 9-6 2-4 5-0 12-2 ...
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of the history of biology 11 (1978), S. 245-267 
    ISSN: 1573-0387
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , History
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Journal of the history of biology 15 (1982), S. 241-262 
    ISSN: 1573-0387
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , History
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Biology and philosophy 3 (1988), S. 214-217 
    ISSN: 1572-8404
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Philosophy
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Biology and philosophy 2 (1987), S. 65-91 
    ISSN: 1572-8404
    Keywords: Nietzsche ; Darwin ; evolution ; epistemology ; sociobiology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Philosophy
    Notes: Abstract Nietzsche was a philosopher, not a biologist, Nevertheless his philosophical thought was deeply influenced by ideas emerging from the evolutionary biology of the nineteenth century. His relationship to the Darwinism of his time is difficult to disentangle. It is argued that he was in a sense an unwitting Darwinist. It follows that his philosophical thought is of considerable interest to those concerned to develop an evolutionary biology of mankind. His approach can be likened to that of an extraterrestrial sociobiologist studying “clever beasts... in some out of the way corner of the universe ...” It is shown how be uses this viewpoint to account for the origin of the central psychobiology of humankind: for dualistic philosophies, such as that of Descartes (which Ryle famously called ‘the official doctrine’), for human notions of ‘truth’ and ‘falsehood’, ‘being’ and ‘becoming’, and for other fundamental concepts of Western philosophy and science. All these, he argues, are no more and no less than the necessary adaptations of a zoological species, Homo sapiens, in its ‘struggle for life’ in a Darwinian world. It is concluded that Nietzsche was the first philosopher to accept and use in their full depth the philosophical implications of nineteeth-century evolutionism, implications which are still resisted to this day. It is also argued that this interpretation of Nietzsche's aphoristic writings provides them with an organic consistency.
    Type of Medium: Electronic Resource
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