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  • 1
    Publication Date: 2016-06-09
    Language: English
    Type: article , doc-type:article
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  • 2
    Publication Date: 2016-06-09
    Language: English
    Type: article , doc-type:article
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  • 3
    Publication Date: 2016-06-09
    Language: English
    Type: article , doc-type:article
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  • 4
    Publication Date: 2016-06-09
    Language: English
    Type: article , doc-type:article
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  • 5
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract A study was conducted on the feasibility of isolating genes and pseudogenes that map to chromosome 13 by a hybridization-based approach using a 13-specific library and pools of repeat-free cDNA clones. Five pairs of cDNA and chromosome 13 genomic clones were identified and characterized. Partial or full-length sequence was derived from all cDNAs, and database searches were performed for putative gene identification. Partial sequence was also obtained from the chromosome 13 genomic clones for comparison with those of the hybridizing cDNAs. As a result of these analyses we identified three genes, a putative homologue of a porcine mRNA encoding an unidentified hepatic protein, a putative homologue of a yeast integral membrane protein, and a gene for a translationally controlled tumor protein, and two processed pseudogenes, ribosomal proteins L23a and S3a. The latter was formerly identified as the v-fos transformation effector gene, Fte-1, and recently cited as a possible candidate for the BRCA2 gene on chromosome 13. All genes and pseudogenes were localized to cytogenetic bands by in situ hybridization of metaphase chromosomes with probes derived from the chromosome 13 genomic clones.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-0738
    Keywords: Key wordsd-Amphetamine  ;  Catecholamines  ;   Hyperthermia  ;  Freshly isolated rat hepatocytes  ;   Hepatotoxicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Amphetamines are indirect-acting sympathomimetic drugs widely abused due to their physical and psychostimulating effects. However, the use of these drugs has been associated with numerous reports of hepatotoxicity. While glutathione depletion induced by amphetamines contributes to the exposure of hepatocytes to oxidative damage, other indirect effects attributed to amphetamines may have a role in cell injury. To examine this possibility, Wistar rats were used for plasma measurements of d-amphetamine and catecholamines (noradrenaline, adrenaline and dopamine) (15 min) after i.p. injection of d-amphetamine (5, 20 and 80 mg/kg). Freshly isolated rat hepatocytes were put into contact for 2 h with concentrations of d-amphetamine and catecholamines similar to those found in vivo. Since hyperthermia is a common consequence of acute amphetamine intake, the study using isolated hepatocytes was conducted at 37 °C and also at 41 °C in order to simulate high temperature levels. We found that hyperthermia was an important cause of cell toxicity: in vitro, a rise in incubation temperature from 37 to 41 °C causes oxidative stress in freshly isolated rat hepatocytes, as shown by a depletion of reduced glutathione (GSH; 23%), an increase of oxidized glutathione (GSSG; 157%), the induction of lipid peroxidation with 77% increase of thiobarbituric acid substances TBARS) and the consequent loss of cell viability (≤ 44%). Single treatment of isolated hepatocytes with catecholamines at 37 °C induced lipid peroxidation (29% increase of TBARS) but had no effect on glutathione or cell viability. Conversely, a single treatment with d-amphetamine induced glutathione depletion (≤ 24% depletion of GSH) with no effect on lipid peroxidation or cell viability. Also, d-amphetamine potentiated the induction by catecholamines of lipid peroxidation at 37 °C (≤ 48% increase of TBARS), while concomitant treatment of d-amphetamine and catecholamines potentiated cell death at 41 °C (≤ 56% of cell death) although no effect on viability was seen at 37 °C. It is concluded that the aforementioned modifications induced by d-amphetamine in vivo are cytotoxic to freshly isolated rat hepatocytes.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Bradford : Emerald
    Journal of financial regulation and compliance 13 (2005), S. 229-253 
    ISSN: 1358-1988
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Economics
    Notes: We discuss the consequences of liberalization on capital market performance. Greater autonomy is expected to bring efficiency, profit and augmented welfare. In some cases, this higher autonomy has also been connected to episodes of fraud. We discuss the role a regulatory activity can play into such a scenario. In order to do it, we focus on factors such as volatility and performance of capital markets, and we analyze the hypothesis that the capital markets' functioning is conditioned by the regulatory activity. We analyze firms' strategies by studying the specific case of Enron. This analysis allowed us to relate firms' behaviour, motivation and strategies with the necessity of a regulatory process on capital markets, in order to achieve an environment of confidence where the market can fulfil its objectives. Our results point out for the existence of a positive relationship between our proxy of the regulatory activity and the level of stock market index. Our results also pointed out for the existence of a negative relationship between the conditional volatility modelled by GARCH models and the growth rate of that regulatory index. The use of autoregressive process had the objective to include in the model the expectations formed in the capital market in previous periods.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 35 (2005), S. 0 
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background We have recently isolated two distinct components from Ascaris suum adult worms with different effects on the immune system: the allergenic protein of A. suum (APAS-3), which induces IgE antibody production, and suppressive protein of A. suum (PAS-1), which inhibits humoral and cellular immune responses induced by unrelated antigens. In this study, we investigated the immunomodulatory effect of PAS-1 on a murine model of asthma induced by APAS-3.Methods BALB/c mice were immunized twice with APAS-3 or APAS-3 plus PAS-1 by the intraperitoneal and subcutaneous route (on days 0 and 7) and challenged twice with the same antigens intranasally (days 14 and 21). Two days after the last challenge, the allergic airway inflammation was evaluated by cellular migration, eosinophil peroxidase (EPO) activity, cytokine and chemokine production and pulmonary mechanical parameters.Results The allergenic properties of APAS-3 were confirmed by the stimulation of anaphylactic IgE and IgG1 antibody production and eosinophilic airway inflammation and hyper-responsiveness. On the other hand, PAS-1-treated mice showed a marked suppression of cellular migration and EPO activity that correlated well with a significant reduction in the levels of IL-4, IL-5, eotaxin and RANTES in the bronchoalveolar lavage (BAL) fluid. In contrast, considerable amounts of IL-10 were observed in the BAL fluid of PAS-1-treated mice. Airway hyper-responsiveness was obtained in APAS-3-immunized mice, but the conductance of the respiratory system was restored to normal values in the presence of PAS-1.Conclusion These results indicate that A. suum allergenic protein APAS-3 induces a T helper 2-type immune response and, consequently, eosinophilic airway inflammation and hyper-responsiveness. Moreover, the modulatory protein PAS-1 has a marked suppressive effect on this response, and the inhibition of cytokine (IL-4, IL-5) and chemokine (eotaxin and RANTES) release, probably because of the presence of IL-10, may contribute to this effect.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Industrial & engineering chemistry research 27 (1988), S. 1269-1277 
    ISSN: 1520-5045
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Magnetic and electrical resistivity measurements performed in Er(Co1−xNix)2 have shown that the critical concentration for the first-order magnetic phase transition is near to xc=0.10. For higher Ni concentration the results suggest that Co is no longer magnetic. Experimental results presented here for Er(Co0.8Ni0.2xFe0.2(1−x))2 and Er(Co0.9Ni0.1xFe0.1(1−x))2 systems, show that when Co is replaced by Fe, the 3d band is filled up, whereas for Ni substitution that band is depleted. The saturation moment obtained from isothermal magnetization measurements indicates that Co recovers its moment and couples parallel to the Fe moment and antiparallel to the Er moment. Characteristics of spin fluctuation are also observed. These results show that with a suitable combination of Co, Ni, and Fe we can recover the original density of the states of the ErCo2 compound. © 1998 American Institute of Physics.
    Type of Medium: Electronic Resource
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