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  • 1
    Electronic Resource
    Electronic Resource
    Conservation and change of the developmentally crucial fushi tarazu gene in Drosophila (1993)
    Springer
    Journal of molecular evolution 36 (1993), S. 315-326 
    Details
    ISSN: 1432-1432
    Keywords: Drosophila ; Fushi tarazu ; Functional constraints ; Regulatory elements
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary We have studied the evolutionary changes occurring in the noncoding regions around the developmentally important fushi tarazu (ftz) gene in a total of 11 species in the genus Drosophila. Previous molecular developmental studies have identified DNA elements both 3′ and 5′ to the coding region which are important in proper regulation of expression of the Drosophila melanogaster ftz gene. We show here that these same elements are the most evolutionarily conserved regions in the vicinity of the gene homologs. Parts of some control elements are more conserved than exonic sequences. Not only is there sequence conservation, but the relative position, orientation, and distances among the control elements remain conserved. One quite significant difference does exist between the two major subgenera studied, Sophophora and Drosophila: namely, an inversion of the ftz unit with respect to other genes in the Antennapedia complex, ANT-C. As a comparison, we applied similar analysis to a “housekeeping” gene-rosy (ry), or Xdh. In contrast, DNA sequences 5′ to the ry coding region revealed little evolutionary conservation. These studies bear out the proposition that functionally important DNA sequences remain more conserved through evolutionary time than do less functionally important sequences. This proposition could be tested in the present case because we could predict a priori from the developmental studies which DNA regions should be most conserved.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00182179
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  • 2
    Electronic Resource
    Electronic Resource
    Mitochondrial DNA evolution in theobscura species subgroup ofDrosophila (1990)
    Springer
    Journal of molecular evolution 31 (1990), S. 122-131 
    Details
    ISSN: 1432-1432
    Keywords: Drosophila obscura subgroup ; Mitochondrial DNA ; Restriction maps ; Phylogeny
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Mitochondrial DNA (mtDNA) restriction site maps for nine species of theDrosophila obscura subgroup and forDrosophila melanogaster were established. Taking into account all restriction enzymes (12) and strains (45) analyzed, a total of 105 different sites were detected, which corresponds to a sample of 3.49% of the mtDNA genome. Based on nucleotide divergences, two phylogenetic trees were constructed assuming either constant or variable rates of evolution. Both methods led to the same relationships. Five differentiated clusters were found for theobscura subgroup species, one Nearctic, represented byDrosophila pseudoobscura, and four Palearctic, two grouping the related triads of speciesDrosophila subobscura, Drosophila madeirensis, Drosophila guanche, andDrosophila ambigua, Drosophila obscura, Drosophila subsilvestris, and two more represented by one species each,Drosophila bifasciata, andDrosophila tristis. The different Palearctic clusters are as distant between themselves as with the Nearctic one. For the related speciesD. subobscura, D. madeirensis, andD. guanche, the pairD. subobscura-D. madeirensis is the closest one. The relationships found by nucleotide divergence were confirmed by differences in mitochondrial genome size, with related species sharing similar genome lengths and differing from the distant ones. The total mtDNA size range for theobscura subgroup species was from 15.5 kb forD. pseudoobscura to 17.1 forD. tristis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02109481
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  • 3
    Electronic Resource
    Electronic Resource
    A species specific satellite DNA family of Drosophila subsilvestris appearing predominantly in B chromosomes (1995)
    Springer
    Chromosoma 103 (1995), S. 539-544 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract This paper describes a species specific satellite DNA family (pSsP216) of Drosophila subsilvestris, a palearctic species of the D. obscura group. The pSsP216 family consists of tandemly arranged 216 bp repetitive units that are predominantly localized on B chromosomes. These chromosomes appear in variable numbers in the karyotype of this species. Some pSsP216 repeats can also be detected in the centromeric heterochromatin of the acrocentric A chromosomes. Two strains, one with and the other without B chromosomes, were investigated for sequence variability and for the location of this satellite DNA on the chromosomes. Among 16 clones of the 216 bp basic repeat unit an overall similarity of about 93% and no strain specific differences were found, indicating that the B chromosomes may have derived from the A chromosomes (probably the dots) by spontaneous amplification of the pSsP216 satellite DNA family.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00355318
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  • 4
    Electronic Resource
    Electronic Resource
    Final height and predicted height in boys with untreated constitutional growth delay (1995)
    Springer
    European journal of pediatrics 154 (1995), S. 627-632 
    Details
    ISSN: 1432-1076
    Keywords: Key words Final height ; Constitutional growth delay ; Height ; prediction ; Bone age ; Males
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report on 49 boys with constitutional growth delay (CGD) who were initially seen in our clinic at a mean chronological age of 13.3 years (range, 7.3–16.4) and a bone age of 11.1 years (range, 6.0–13.5). All were below the 5th height percentile for chronological age. A positive family history with delayed growth and puberty in one or both parents could be elicited in 75%. All 49 patients were re-examined at a mean age of 22.9 years (range, 20.4–31.2). Measured final height was 171.3 cm (range, 161.2–181.7), which was slightly, but significantly lower than mean target height of 173.0 cm. Final height expressed as standard deviation score (SDS) of a male adult population standard was –1.0 (range, –2.4 to +0.5) , also significantly lower than initial height SDS related to bone age (SDSBA) of –0.5 (range, –1.6 to +1.2). If related to target height (Tanner), final height was found to correlate positively with the initial bone age deficit and the initial height SDSBA. Observed final height was also compared with the predicted adult height by the methods of Bayley-Pinneau (BP), Tanner-Whitehouse Mark II (TW II) and Roche-Wainer-Thissen. Regression equations between all three prediction methods and final height showed an excellent correlation (P 〈 0.0001). However, only by the BP method was predicted height very close to and no different from measured final height (paired t-test). Despite this, final height in 16 of 49 patients (32.6%) differed by more than 5.0 cm from BP predicted height. An overwhelming majority of the patients (88.6%) expressed complete or reasonable satisfaction with their adult height. Conclusion In our sample of male patients with CGD, adult height came close to but did not quite reach mean target height. The BP prediction method offers a good compromise between simplicity and accuracy but must be used judiciously because individual discrepancies with attained final height may be large and unexplained.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02079065
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  • 5
    Electronic Resource
    Electronic Resource
    Final height and predicted height in boys with untreated constitutional growth delay (1995)
    Springer
    European journal of pediatrics 154 (1995), S. 627-632 
    Details
    ISSN: 1432-1076
    Keywords: Final height ; Constitutional growth delay ; Height prediction ; Bone age ; Males
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Abstract We report on 49 boys with constitutional growth delay (CGD) who were initially seen in our clinic at a mean chronological age of 13.3 years (range, 7.3–16.4) and a bone age of 11.1 years (range, 6.0–13.5). All were below the 5th height percentile for chronological age. A positive family history with delayed growth and puberty in one or both parents could be elicited in 75%. All 49 patients were re-examined at a mean age of 22.9 years (range, 20.4–31.2). Measured final height was 171.3 cm (range, 161.2–181.7), which was slightly, but significantly lower than mean target height of 173.0 cm. Final height expressed as standard deviation score (SDS) of a male adult population standard was −1.0 (range. −2.4 to +0.5), also significantly lower than initial height SDS related to bone age (SDSBA) of −0.5 (range, −1.6 to +1.2). If related to target height (Tanner), final height was found to correlate positively with the initial bone age deficit and the initial height SDSBA. Observed final height was also compared with the predicted adult height by the methods of Bayley-Pinneau (BP), Tanner-Whitehouse Mark II (TW II) and Roche-Wainer-Thissen. Regression equations between all three prediction methods and final height showed an excellent correlation (P〈0.0001). However, only by the BP method was predicted height very close to and no different from measured final height (pairedt-test). Despite this, final height in 16 of 49 patients (32.6%) differed by more than 5.0 cm from BP predicted height. An overwhelming majority of the patients *88.6%) expressed complete or reasonable satisfaction with their adult height. Conclusion In our sample of male patients with CGD, adult height came close to but did not quite reach mean target height. The BP prediction method offers a good compromise between simplicity and accuracy but must be used judiciously because individual discrepancies with attained final height may be large and unexplained.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02079065
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Cloning and characterization of KM190, a specific satellite DNA family of Drosophila kitumensis and D. microlabis
    Amsterdam : Elsevier
    Gene 120 (1992), S. 267-269 
    Details
    ISSN: 0378-1119
    Keywords: Recombinant DNA ; nucleotide sequence ; repetitive DNA ; sequence analysis ; tandem repeats
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0378-1119(92)90103-V
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  • 7
    Electronic Resource
    Electronic Resource
    Satellite DNA as a taxonomic marker
    Amsterdam : Elsevier
    Biochemical Systematics and Ecology 21 (1993), S. 3-11 
    Details
    ISSN: 0305-1978
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0305-1978(93)90004-B
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  • 8
    Electronic Resource
    Electronic Resource
    Hyperfine splitting in the electron spin resonance of europium in SnTe
    Amsterdam : Elsevier
    Physics Letters A 42 (1972), S. 117-118 
    Details
    ISSN: 0375-9601
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0375-9601(72)90734-7
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  • 9
    Electronic Resource
    Electronic Resource
    Crystal field splitting of gadolinium in single crystals of metallic LaBi
    Amsterdam : Elsevier
    Physics Letters A 49 (1974), S. 418-420 
    Details
    ISSN: 0375-9601
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0375-9601(74)90296-5
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  • 10
    Electronic Resource
    Electronic Resource
    Electronic structure of the metallic tungsten bronces La"x"-"yGd"yWO"3 (ESR measurements)
    Amsterdam : Elsevier
    Physics Letters A 45 (1973), S. 423-425 
    Details
    ISSN: 0375-9601
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0375-9601(73)90268-5
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