Electronic Resource
Suite 500, 5th Floor, 238 Main Street, Cambridge, Massachusetts 02142, USA
:
Blackwell Science Inc.
International journal of gynecological cancer
5 (1995), S. 0
ISSN:
1525-1438
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Pseudomyxoma peritoneii has an indolent course but a 5-year survival rate of 40–45%. The role for postoperative intraperitoneal chemotherapy is unclear. Nine patients with pseudomyxoma arising from mucinous neoplasms of the ovary and intestinal tract received a total of 89 courses of intraperitoneal 5-fluorouracil (IP5FU). Each course consisted of eight 4-h exchanges of 1 g of 5FU in 2 l of 1.5% Inpersol®. Median follow-up after diagnosis was 30 months (range 6–74). All patients were evaluable for toxicity and response. There was one treatment-related death due to renal failure and sepsis. Three patients developed disease progression prior to scheduled second-look laparotomy. At second-look laparotomy two patients demonstrated pathologic complete responses, one had stable disease and one had progression of disease. One patient remained clinically free of progression after refusing second-look laparotomy. The projected 5-year survival by Kaplan-Meier estimate was 87% for patients treated with IP5FU compared to a 52% 5-year survival seen in a series of 11 patients treated prior to the use of IP5FU (P = 0.12). This preliminary analysis suggests that IPFU in the described schedule fails to improve survival statistically compared to previously used regimens for patients with pseudomyxoma peritoneii.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1046/j.1525-1438.1995.05050361.x
Permalink
| Library |
Location |
Call Number |
Volume/Issue/Year |
Availability |
