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  • 1
    Electronic Resource
    Electronic Resource
    Optical Rotary Dispersion Studies. CIX.1 An Octant Rule for the Azide Chromophore2 (1967)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 89 (1967), S. 347-352 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00978a031
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  • 2
    Electronic Resource
    Electronic Resource
    The Diabetes Atherosclerosis Intervention Study (DAIS): a study conducted in cooperation with the World Health Organization (1996)
    Springer
    Diabetologia 39 (1996), S. 1655-1661 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Diabetes mellitus ; atherosclerosis ; intervention trial ; fenofibrate ; lipoprotein ; coronary angiography.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The incidence of coronary artery disease is greatly increased in those with diabetes mellitus. The largest number of those who have coronary artery disease have non-insulin-dependent diabetes (NIDDM). Lipoprotein abnormalities have been identified among the several risk factors that could account for this increase in atherosclerosis. There have been many studies demonstrating that correction of dyslipoproteinaemias will reduce the risk of coronary disease in non-diabetic populations. Current advice to those with diabetes is based on extrapolations from such studies. However, the justification for this, and the treatment targets are unclear as there has been no direct test of the lipid hypothesis in diabetes. This paper describes the protocol of the first intervention trial designed to examine directly whether correcting dyslipoproteinaemia in men and women with NIDDM will reduce their coronary artery disease. The Diabetes Atherosclerosis Intervention Study (DAIS), is a multinational angiographic study using the 200 mg micronized form of fenofibrate in a double-blind, placebo-controlled protocol. [Diabetologia (1996) 39: 1655–1661]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050630
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  • 3
    Electronic Resource
    Electronic Resource
    Diabetes mellitus, dyslipoproteinaemias and atherosclerosis (1997)
    Springer
    Diabetologia 40 (1997), S. S147 
    Details
    ISSN: 1432-0428
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250051433
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  • 4
    Electronic Resource
    Electronic Resource
    Experimentelle Untersuchungen zur Pathologie und Therapie der Spirochätenkrankheiten (1926)
    Springer
    Journal of molecular medicine 5 (1926), S. 499-502 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung 1. Schwache Recurrens-Erstinfektionen lassen sich während ihres Verlaufes durch Einimpfung von spirochätenreichem Passageblut verstärken, es kommt zu Superinfektionen. 2. Die Immunitätsdauer ist bei der wei\en Ratte und der wei\en Maus trotz gleichen Ausgangsstammes und gleicher Stärke der Infektion verschieden lang. 3. In der späten Periode der Immunität besteht die Möglichkeit zur Herauszüchtung von in die Blutbahn eingeimpften Spirochäten, ohne da\ es zur Infektion kommt. 4. Durch vorherige intraperitoneale oder intrakardiale Behandlung mit virulenten Spirochäten wird die kurzdauernde Persistenz neu intrakardial eingeimpfter Spirochäten in der Blutbahn verhindert. Es ist hieraus zu schlie\en, da\ durch eine solche Nachimpfung mit aktivem Virus der Immunkörpertiter des Serums erhöht wird. 5. Diese Immunkörpertitererhöhung geht nach einigen Wochen wieder verloren, so da\ eine erneute kurz dauernde Persistenz intrakardial eingeimpfter Spirochäten in der Blutbahn zustande kommt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01728740
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  • 5
    Electronic Resource
    Electronic Resource
    Experimentelle Untersuchungen zur Pathologie und Therapie der Spirochätenkrankheiten (1927)
    Springer
    Journal of molecular medicine 6 (1927), S. 1597-1599 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung 1. Durch die parabiotische Vereinigung eines Immuntieres mit einem gesunden ist es uns nicht gelungen, die im Gehirn des Immuntieres persistenten Spirochäten zu mobilisieren und aus der Blutbahn herauszuzüchten. Weder durch kurzfristige, noch durch bis zu 8 Tagen dauernde Vereinigung konnten die „Hirnspirochäten“ irgendwie beeinflußt werden. 2. Während der Parabiose eines Immuntieres mit einem Normaltier gehen schon nach kurzer Zeit soviel Immunstoffe auf das Normaltier über, daß dieses als passiv immunisiert bezeichnet werden kann. Der Grad dieser Immunisierung hängt von der Dauer und dem Bestande der parabiotischen Vereinigung ab. 3. Ein während einer Parabiose passiv immunisiertes Normaltier war seinerseits nicht imstande, in einer zwischen ihm und einem gesunden Tiere angelegten Parabiose erhebliche Immunkräfte auf das gesunde Tier zu übertragen. 4. Erkrankt ein noch verhältnismäßig kurze Zeit immunes Tier während der Parabiose neuerdings an einem Spirochätenrezidiv im Blut, so wird das mit diesem Tier verbundene Normaltier nicht unmittelbar krank, sondern zeigt (in unserem Falle) eine bis zu 21 Tagen dauernde latente Infektion, die erst mit dem allmählichen Abklingen der dem Normaltier vermittelten passiven Immunität manifest wird. 5. Histologische Untersuchungen haben ergeben, daß schon bei kurzdauernder parabiotischer Vereinigung eines immunen mit einem gesunden Tier in dem dem immunen Tier zunächst gelegenen Normaltierhautanteil eine Zone zu finden ist, in der sich die Immunwirkung bemerkbar macht.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01716130
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  • 6
    Electronic Resource
    Electronic Resource
    Eine neue präparative Methode zur Gewinnung von Immunkomplexbestandteilen, dargestellt am Beispiel der Rheumatoid-Arthritis (1982)
    Springer
    Journal of molecular medicine 60 (1982), S. 1415-1421 
    Details
    ISSN: 1432-1440
    Keywords: Immune complexes ; Immune complex analysis ; Rheumatoid factor ; Antibody specificity ; Rheumatoid arthritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Immune complexes were precipitated under defined conditions using polyethleneglycol. The precipitation was subjected to the first electrophoresis under nondecomposed conditions for immune complexes. In this way IgG can essentially be separated from the immune complexes which remain in the place where they were applied. In a second electrophoresis, the broken immune complexes were fractionated into IgM and IgG bands. These were analysed for antibody activity by means of hemagglutination and immunofluorescent methods. In serum of 20 rheumatoid arthritis patients, we could detect in the IgM fraction of the immune complexes the rheumatoid factor, an antinuclear antibody, and a new unknown antibody directed against cell plasma membranes of human muscle cells and endothelial cells. The importance of this new antibody in the pathogenesis was discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01716247
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  • 7
    Electronic Resource
    Electronic Resource
    Experimentelle Untersuchungen zur Pathologie und Therapie der Spirochätenkrankheiten (1926)
    Springer
    Journal of molecular medicine 5 (1926), S. 1599-1601 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung 1. Recurrensspirochäten können aus dem intracutanen Gewebsraum eines excidierten und wieder implantierten Hautlappens in das lebende Gewebe einwandern. 2. Der Austritt der Spirochäten aus einem, einer gesunden Ratte implantierten, völlig verschlossenen Hautbeutel in die normale Ratte hinein ist durch das Zustandekommen der Infektion bewiesen. 3. Haut und Hautbeutel von Recurrensimmunratten lassen die Recurrensspirochäten nicht durch.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01850795
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  • 8
    Electronic Resource
    Electronic Resource
    Surface enhanced FTIR spectroscopy on membranes (1998)
    Springer
    Fresenius' journal of analytical chemistry 360 (1998), S. 750-754 
    Details
    ISSN: 1432-1130
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The infrared absorption of molecules in the vicinity of small metal clusters is enhanced due to an electric field around the clusters. This phenomenon is known as surface enhanced IR absorption (SEIRA). The potential of SEIRA consists in the investigation of thin layers and of membranes. SEIRA was used to detect small and specific changes in the structure of biomembranes applying two configurations: underlayer and overlayer. In the underlayer configuraiton, IR transparent Ge crystals were coated with Ag clusters before vesicles were adsorbed. In the overlayer configuration, the vesicles were first absorbed on neat Ge crystals before a layer of Ag clusters was condensed on top. An intensity increase in the SEIRA spectra was observed for both configurations compared to FTIR spectra without Ag clusters.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002160050799
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  • 9
    Electronic Resource
    Electronic Resource
    Infrared and Raman imaging of biological and biomimetic samples (2000)
    Springer
    Fresenius' journal of analytical chemistry 366 (2000), S. 712-726 
    Details
    ISSN: 1432-1130
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Established methods for imaging of biological or biomimetic samples, such as fluorescence and optical microscopy, magnetic resonance imaging (MRI), X-ray tomography or positron emission tomography (PET) are currently complemented by infrared (both near-IR and mid-IR) as well as Raman spectroscopic imaging, whether it be on a microscopic or macroscopic scale. These vibrational spectroscopic techniques provide a wealth of information without a priori knowledge of either the spectral data or the composition of the sample. Infrared radiation does not harm the organism, no electric potential needs to be applied, and the measurements are not influenced by electromagnetic fields. In addition, no extrinsic labeling or staining, which may perturb the system under investigation, has to be added. The immense volume of information contained in spectroscopic images requires multivariate analysis methodologies in order to effectively mine the chemical and spatial information contained within the data as well as to analyze a time-series of images in order to reveal the origin of a chemical or biochemical process. The promise and limitations of this new analytical tool are surveyed in this review.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002160051565
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    Plasma glutathione peroxidase after selenium supplementation in patients with reduced selenium state (1982)
    Springer
    European journal of pediatrics 138 (1982), S. 138-140 
    Details
    ISSN: 1432-1076
    Keywords: Selenium ; Supplementation ; Plasma ; Glutathione peroxidase ; Glutathione S-transferase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The plasma glutathione peroxidase (GSHPx) activity was measured in normal adults and children and in patients with reduced selenium state because of dietary treatment of metabolic diseases (phenylketonuria or maple-syrup-urine disease) before and after selenium supplementation. Besides GSHPx (measured with t-butyl hydroperoxide, cumene hydroperoxide and hydrogen peroxide as acceptor substrates) the activity of glutathione S-transferase was estimated in plasma. Plasma GSHPx activity in healthy children was significantly lower than in healthy adults. In 11 dietetically treated patients with phenylketonuria or maple-syrup-urine disease the plasma GSHPx was reduced to about 17% of the values of healthy children of the same age. No glutathione S-transferase activity could be found in plasma of children in normal or reduced Se state. During administration of yeast rich in Se (200μg Se/d) for 90 days 2 healthy adults showed no significant change of plasma GSHPx activity. During Se supplementation (75–100μg Se/d) for 120–163 days 5 dietetically treated patients with PKU or MSUD exhibited a significant increase of plasma GSHPx activity within 2 days. The values reached a plateau after 1 to 3 weeks of supplementation and remained at this level within the following 4 to 5 months. Therefore, the activity of plasma glutathione peroxidase can be used as an indicator of short-term changes of selenium intake in selenium deficient individuals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00441140
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