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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 55 (1977), S. 711-712 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 56 (1978), S. 482-482 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 56 (1978), S. 893-893 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European biophysics journal 18 (1990), S. 57-62 
    ISSN: 1432-1017
    Keywords: Protein dynamics ; Spin label ; Electron paramagnetic resonance ; Hemoglobin ; Viscosity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Abstract The residual motion of spin labels bound to cysteine β93 and to lysines of methemoglobin has been studied by electron paramagnetic resonance spectroscopy. To separate the influences of the solvent and the protein environment of the label fluctuations, the correlation times, τ, were analyzed as a function of temperature for fixed solvent viscosities, η. Results show that over a wide range of viscosity the dependence of τ on η may be empirically described by a power law τ∼η k . The exponent k depends strongly on the location of the label on the protein surface. If one regards the spin labels as artificial amino acid side chains, characteristic values of correlation times and amplitudes of the rotational motion at the surface can be given. For η=1 cP and T=297 K the correlation time of the labels bound to lysines is found to be τ=9 · 10−10 s and the rotational diffusion is nearly isotropic. The spin label bound to cysteine β93 occupies a protein pocket, its rotational motion is therefore restricted. The correlation time of the label motion within a limited motion cone of semi angle θ=30° ± 3° is found to be τ=1.3 · 10−9 s for η=1 cP and T=297 K.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 26 (1972), S. 99-120 
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The results of an analysis of 2460 brain scans are as follows: 1. Cerebral Scintigraphy using99mTc-Pertechnetate occupies a highly reliable position among the methods used for the localization ofsupratentorial tumours. Only up to 22% of supratentorial tumours can be precisely localized by echoencephalography23, and the localizing accuracy of the electroencephalograph stands no higher than about 60%20, whilst the brain scan with an 84% localization is almost as accurate as cerebral angiography. 2. Withinfratentorial tumours brain scanning in contrast to angiography provides substantially less diagnostic information. Nevertheless, it should be set in hand when the suspicion of an infratentorially situated tumour arises, especially with an out-patient. 3. With regard to localisation: Thediagnose “brain tumour” can be achieved in 58% from the scintigraphic storage picture. This percentage corresponds to that of our results with cerebral angiography. By considering the brain scan and the angiographic results together the diagnosis of tumour becomes possible in 63%. 4. The Differentiation between tumour and softening or haemorrhage using99mTc-scintigraph, is possible only in exceptional cases, but can be improved by the employment of the combined brain scan with75Se-Sodium Selenite. 5. In those cases in which scanning alone has provided the diagnosis of tumour one shouldnot renounce angiography because the knowledge of the relationship of the tumour to the vascular system is of great importance to the operation. In addition, angiography makes it possible to diagnose the tumour type in a higher percentage than with brain scanning. Purely by means of the brain scan, an exact diagnosis of the type of tumour can almost always be made only with sphenoidal wing meningiomas. 6. The recognition ofacute intracranial haematomata remains reserved for echo-encephalography and cerebral angiography because the haematoma in its early stages shows no scintigraphic concentration. Withcerebral infarctions brain scanning, in contrast to angiography, makes possible in many cases the precise assessment of the extent of the infarcted territory. In addition it has a prognostic value because large intensively delineated infarcts have a bad prognosis. 7. In addition brain scanning is especially suited as a screening technique when one suspects a chronic subdural haematoma or wishes to exclude an abscess. This is because chronic subdural haematoma can be recognised in 81%–91%, and abscesses in approximately 100%, of brain scans. 8. C.S.F. scanning with I 131 human serum albumen makes it possible to demonstrate traumatic or atraumatic fistulae, and is also suited to the display of disorders of C.S.F. circulation, as for example in posttraumatic hydrocephalus due to failure of C.S.F. absorption.
    Notes: Zusammenfassung 2460 Hirnszintigraphien wurden analysiert. Die Ergebnisse der Analyse sind folgende: 1. Die Hirnszintigraphie mit99mTc-Petechnetat besitzt eine hohe Leistungsfähigkeit bei der Lokalisation vonsupratentoriellen Hirntumoren. Während im Echoenzephalogramm supratentoriell gelegene Tumoren generell nur zu 22% genau lokalisiert werden können23 und im Elektroenzephalogramm generell nur eine exakte lokalisatorische Treffsicherheit von ca. 60% besteht20, ist sie bei der Hirnszintigraphie mit 84% etwa gleich groß wie bei der cerebralen Angiographie. 2. Beiinfratentoriellen Tumoren besitzt die Hirnszintigraphie im Gegensatz zur Angiographie eine wesentlich geringere diagnostische Aussagefähigkeit. Sie sollte dennoch bei Verdacht auf einen infratentoriell gelegenen Tumor bereits im Rahmen der ambulanten Diagnostik eingesetzt werden. 3. Nach dem szintigraphischen Speicherungsbild kann unter Berücksichtigung der Lokalisation in 58% dieDiagnose Hirntumor gestellt werden. Dieser Prozentsatz entspricht unseren Ergebnissen mit der cerebralen Angiographie. Bei Berücksichtigung des szintigraphischen und des angiographischen Ergebnisses ist die Tumordiagnose in 63% möglich. 4. DieAbgrenzung von Tumoren gegenüber Erweichungen und Blutungen, die im99mTc-Szintigramm nur in Ausnahmefällen möglich ist, kann durch den Einsatz der kombinierten Hirnszintigraphie mit75Se-Natriumselenit verbessert werden. 5. In den Fällen, in denen rein szintigraphisch eine Tumordiagnose gestellt werden kann, wird man jedochnicht auf die Angiographie verzichten, da die Kenntnis der Beziehung des Tumors zum Gefäßsystem für die Operation von großer Bedeutung ist und die Angiographie außerdem in einem höheren Prozentsatz die Tumorartdiagnose ermöglicht als die Hirnszintigraphie. Eine exakte Tumorartdiagnose kann rein szintigraphisch fast ausschließlich nur beim Keilbeinmeningiom gestellt werden. 6. Der Nachweis vonakuten intrakraniellen Blutungen bleibt der Echoenzephalographie und der cerebralen Angiographie vorbehalten, da Hämatome im Frühstadium keine szintigraphische Anreicherung aufweisen. BeiHirninfarkten ermöglicht die Hirnszintigraphie in vielen Fällen im Gegensatz zur Angiographie die genaue Bestimmung der Ausdehnung des Infarktbezirkes und insofern eine prognostische Aussagefähigkeit, als große, intensiv speichernde Infarkte eine ungünstige Prognose beinhalten. 7. Die Hirnszintigraphie eignet sich besonders auch als Suchmethode bei Verdacht auf ein chronisches Subduralhämatom und zum Ausschluß von Abszessen, da chronische Subduralhämatome zwischen 81 und 91% und Abszesse in etwa 100% szintigraphisch zu erfassen sind. 8. Die Liquorszintigraphie mit131Jod-Humanserumalbumin ermöglicht den Nachweis von traumatischen oder atraumatischen Liquorfisteln und eignet sich zum Nachweis von Liquorzirkulationsstörungen, wie zum Beispiel beim posttraumatischen Hydrocephalus aresorptivus.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Among 2,600 patients, examined by computerized tomography, 404 had brain tumours, which were gliomas in 150 cases. There were 73 glioblastomas. Examination was performed according to Ambrose's method using an intravenous injection of 1 ml 60% contrast medium per kg body weight. Thus 98% of all gliomas could be demonstrated. Glioblastomas are shown in three different forms: an annular type (55%), a nodular type (18%), and a combined type (27%). Perifocal oedema is found in 88% of glioblastomas. The oedema most frequently belongs to grade II or III. Differential diagnosis of gliomas, abscess, metastases and other tumours with central necrosis are discussed.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Biochemical and Biophysical Methods 22 (1991), S. 69-82 
    ISSN: 0165-022X
    Keywords: Hemoglobin ; Permitivity ; Proteib crystal
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Biochemical and Biophysical Methods 17 (1988), S. 237-247 
    ISSN: 0165-022X
    Keywords: EPR ; Environmental polarity ; Rotational correlation time
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular 1121 (1992), S. 189-198 
    ISSN: 0167-4838
    Keywords: Configurational entropy ; Heme binding ; Hemoglobin ; Temperature jump ; Vibrational entropy
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 0167-4838
    Keywords: ESR ; Hemoglobin ; Intramolecular reaction ; Protein dynamics ; Spin transition ; Temperature jump
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
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