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  • 1
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Lebensqualität ; Metaanalyse ; Depressive ; Schizophrene ; Facettenanalyse ; Modulares System ; Key words Quality of life ; Metaanalysis ; Depression ; Schizophrenia ; Facet analysis ; Modular system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The construct Quality of Life (QoL) is investigated by metaanalysis of eight (inter)nationally validated questionnaires in a multicenter study. Data have been collected in a mentally healthy (n=479), a depressed (n=171) and a schizophrenic (n=139) sample. Conventional psychometric criteria and a facet analytical methodology have been applied. The resulting questionnaire „Modular System for Quality of Life” (MSQoL) consists of a core module with 47 items (one „G-factor” and six subdimensions), which is sufficiently valid for all three samples. Additionally, there are four specific modules (demography, family, partnership, profession). No specific modules can be identified for the psychopathological subgroups. The validated radex structure for subjective QoL offers the opportunity for a cumulative research design and for adaptations to the actual setting.
    Notes: Zusammenfassung In einer von der Arbeitsgruppe „Lebensqualität (LQ)” der „Arbeitsgemeinschaft für Methodik und Dokumentation in der Psychiatrie” (AMDP) unterstützten multizentrischen Studie wird das Konstrukt Lebensqualität (LQ) anhand von acht (inter)national validierten Erhebungsinstrumenten sowie einer gesunden (n=479), einer depressiven (n=171) und einer schizophrenen (n=139) Stichprobe metaanalytisch untersucht. Neben herkömmlichen psychometrischen Kriterien liegt der methodische Schwerpunkt dabei auf einem facettenanalytischen Vorgehen. Der resultierende Fragebogen „Modulares System zur Lebensqualität” (MSLQ) besteht aus einem für alle 3 Stichproben hinreichend validen Kernmodul mit 47 Items (ein „G-Faktor” und 6 Subdimensionen) sowie 4 spezifischen Modulen (Demographie, Familie, Partnerschaft, Beruf). Für die psychopathologischen Subgruppen lassen sich keine spezifischen Module etablieren. Die validierte Struktur der subjektiv eingeschätzten Lebensqualität (in Form einer facettenanalytischen Radexkonstellation) bietet die Möglichkeit zu einer kumulativ angelegten Forschung und einer untersuchungsspezifischen Anpassung des MSLQ.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European archives of psychiatry and clinical neuroscience 238 (1989), S. 126-134 
    ISSN: 1433-8491
    Keywords: Long-term outcome ; Schizophrenia ; Schizoaffective disorders ; Prediction ; LISREL analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The influence of symptomatological and non-symptomatological factors on the long-term outcome of schizoaffective and schizophrenic disorders was investigated using the Analysis of Linear Structural Relationships (LISREL). The outcome was assessed employing the GAS, WHO/DAS, PIRS and the Bonn Criteria of Outcome. The analysis produced some interesting results in both groups, separately and in comparison with each other. The most striking difference between the two disorders concerns the finding that only symptomatological parameters directly influence the long-term outcome of schizoaffective disorders — melancholic episodes are correlated with favourable outcome, symptoms typical of schizophrenia with a relatively unfavourable outcome. Both symptomatological parameters (such as schizophrenic first-rank symptoms during course) and non-symptomatological parameters (such as life events or acuteness of onset) have a direct impact on the outcome. It was also found that “simple” depressive symptomatology (the presence of depressive symptoms not fulfilling the criteria of melancholic episodes according to DSM-III-R) has no influence on the long-term outcome of schizophrenia.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European archives of psychiatry and clinical neuroscience 239 (1989), S. 133-139 
    ISSN: 1433-8491
    Keywords: Single case analysis ; Nonparametric time-series analysis ; HTAKA model ; Sleep-deprivation therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Modern statistical approaches to the analysis of single cases have so far been rarely employed in psychiatric therapy research. The recently developed Hierarchical Trend-Segment Component Analysis (HTAKA) seems to be an adequate and practicable method for the field of therapy evaluation, not only under sophisticated research conditions, but also under routine treatment conditions. Using self-rating data of the effects of sleep-deprivation therapy as an example, the results of nonparametric time-series analyses performed according to HTAKA are presented. The statistical agglomeration of the single case results demonstrated that in most cases undergoing repeated sleep deprivation a long-term antidepressive effect related to this therapy could be proven.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European archives of psychiatry and clinical neuroscience 244 (1994), S. 161-169 
    ISSN: 1433-8491
    Keywords: Personality disorders ; Prevalence rates ; Overlap ; Patterns of comorbidity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Although DSM-III-R and ICD-10 suggest the assignment of multiple personality diagnoses, a high degree of overlap may be an indicator of insufficiently distinct and too inclusive types of personality. We studied this problem with a new inventory in an unselected clinical sample. The Aachen List of Items for the Registration of Personality Disorders (AMPS) integrates the different types of disordered personality according to DSM-III-R, ICD-10, and four subaffective categories, which largely follow the typologies of Kracpelin, K. Schneider, and Kretschmer. The prevalence rate of each personality disorder was calculated in a consecutive group of 231 patients. Patterns of comorbidity were computed using odds ratios. More than one personality disorder was found in 41% according to DSM-III-R. ICD-10 showed a significantly higher degree of overlap. Interesting comorbidity patterns are discussed in comparison with several North American studies. Results indicate that clear-cut categorical personality diagnoses are not likely to be set up.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    European archives of psychiatry and clinical neuroscience 235 (1985), S. 110-118 
    ISSN: 1433-8491
    Keywords: Combined insulin tolerance test (ITT) ; Major depressive disorder ; Neuroendocrine dysfunctions ; Path analysis ; Kombinierter Insulin-Hypoglykämie-Test ; depressive Erkrankungen ; neuroendokrine Dysfunktionen ; Pfadanalyse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Mittels eines pfadanalytischen Strukturmodells werden bei unterschiedlichen Subgruppen depressiver Patienten mögliche kausale Zusammenhänge zwischen verschiedenen — im kombinierten Insulin-Hypoglykämie-Test überprüften — hormonellen and neuroendokrinen Funktions-systemen dargestellt unter Berücksichtigung der Kontrollvariablen: Alter, Ernährungszustand, Depressionstiefe und Score in der Newcastle-Scale. Die differente Bedeutung des Ernährungszustandes und der basalen Wachstumshormon-Konzentration für die neuroendokrine Reaktivität im kombinierten Insulin-Hypoglykämie-Test — und damit ihre Wertigkeit als Ausschlußkriterien —wird für die verschiedenen depressiven Subgruppen aufgezeigt. Die Hypothese, wonach alle bei bestimmten Depressiven nachweisbaren neuroendokrinen Dysfunktionen als sekundäre Phänomene der (erhöhten) Cortisol-Basalwerte aufgefaßt werden könnten, findet duch die hier vorgelegten Befunde keine genügende Bestätigung. Die Kerngruppe der endogen mono- und bipolaren Depressionen weist eine enge Verknüpfung der überprüften neuroendokrinen Funktionssysteme — vor ahem über die Cortisol-Basalwerte — untereinander und mit den überprüften Kontrollvariablen auf, so daß sich eine eingeengte Variationsbreite der Reagibilität in den funktionell miteinander zusammenhängenden Systemen ergibt, ein analoger Befund zu Ergebnissen auf der psychophysiologischen Ebene.
    Notes: Summary With the help of an analytical path structure model (causal analysis) the aim of the study was to elucidate further, in female patients with various depressive disorders, some correlations of causal interdependencies between changes both in basal secretion of anterior pituitary hormones and in their responses to the (combined) insulin tolerance test (ITT) with extraneous factors—such as age, deviation from ideal body weight (in percentage), severity of depression and score in the Newcastle Scale (NCS)—that may influence these abnormalities. In various depressive subgroups the strength of influence and the different importance of deviation from ideal body weight and basal growth hormone (GH) concentration (as exclusion criteria) for their neuroendocrine reactivity in the combined ITT was shown. The hypothesis that cortisol hypersecretion may be the primary disturbance and the other possible neuroendocrine changes such as blunted GH, cortisol and TSH responses to stimuli in some depressive patients all may be secondary to the (elevated) cortisol level could not be corroborated. The endogenous mono- and bipolar subtypes of major depressive disorders showed intimate connections between the various neuroendocrine functional systems and the above mentioned extraneous factors resulting in a narrowed variability and a stronger coupling in the reactivity of these hormonal functional systems, a condition which can be seen as analogous to experimental results at the psychophysiological level in these nuclear groups of depressed patients, whose psychopathological state is also characterized by similar limitations in their “degree of freedom” (Heimann).
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    European archives of psychiatry and clinical neuroscience 238 (1989), S. 118-125 
    ISSN: 1433-8491
    Keywords: Long-term outcome ; Schizoaffective disorder ; Schizophrenia ; Social outcome ; Psychopathological outcome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The long-term outcome of 72 schizoaffective and 97 schizophrenic patients with a mean duration of illness of 25.6 years and 19.6 years respectively was investigated. The outcome was assessed using the WHO Disability Assessment Schedule (WHO/DAS), the Psychological Impairment Rating Schedule (PIRS) (also developed by the WHO), the Global Assessment Scale (GAS), and the Bonn Psychopathological Criteria of Outcome. The outcome of schizoaffective disorders was found to differ from that of schizophrenia in several ways: (a) schizoaffectives achieve a full remission significantly more frequently than schizophrenics (50% vs 10%); (b) the development of so-called characteristic schizophrenic residua is the exception in schizoaffective disorders, but is frequent in schizophrenia; (c) disability, psychological impairment and disturbances of the level of functioning are not only significantly less frequent in schizoaffective disorders but are also less intense than in the schizophrenic group. The factors influencing the outcome of the two disorders are different (see part 11), as are the social consequences (part III).
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    European archives of psychiatry and clinical neuroscience 238 (1989), S. 135-139 
    ISSN: 1433-8491
    Keywords: Long-term outcome ; Prediction ; Schizophrenia ; Schizoaffective disorders ; Social consequences
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A significantly higher proportion of schizophrenic than schizoaffective patients were found to experience negative social consequences of their illness. Schizophrenic males are more likely to have an unfavourable social prognosis than are schizophrenic females or schizoaffective patients of either gender. Schizophrenic males are, however, equally disadvantaged in regard to social consequences independently of other premorbid and sociodemographic factors. Unfavourable social consequences in male schizophrenics and favourable ones in female schizoaffectives can be predicted with high probability. Some social consequences can be predicted with relatively high probability for male schizoaffectives, while no prognosis can be made for female schizophrenics.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Schizophrenie ; Psychoseprädiktion ; Selbst wahrgenommene neuropsychologische Defizite ; Basisstörungen ; Key words Schizophrenia ; Prediction of psychosis ; Self-experienced neuropsychological deficits ; Basic disorders
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summery For the first time, the present study assessed the achievable predictive value of early self-experienced neuropsychological deficits for the fater development of schizophrenia. Ninety-six patients with DSM-III-R diagnoses mainly of the formerly neurotic or personality disordered field, of whom 81 % had shown such basic disorders at the time of the index examination and therefore were classified as persons at high risk of developing schizophrenia, were re-examined for schizophrenia. After an average follow-up period of about 8 years, more than half of the re-examined sample had developed a schizophrenic disorder according to DSM-III-R. The outcome of schizophrenia versus no schizophrenia was predicted correctly in 77 % of cases by the presence or absence of self-experienced disturbances of perception, thought, speech or action.
    Notes: Zusammenfassung Diese Studie überprüft erstmals die mögliche prädiktive Aussagekraft früher selbst wahrgenommener neuropsychologischer Defizite für die spätere Entwicklung einer Schizophrenie. 96 Fälle mit DSM-III-R-Diagnosen vorwiegend aus dem Bereich der Neurosenachfolgebestimmungen und Persönlichkeitsstörungen, die bei der Indexuntersuchung zu 81 % solche Basisstörungen geboten hatten und deshalb gemäß der Prüfhypothese als stark psychosegefährdete Patientengruppe einzustufen waren, wurden im Hinblick auf schizophrene Symptombildungen nachuntersucht. Nach einer Follow-up-Periode von durchschnittlich ca. 8 Jahren hatte mehr als die Hälfte dieser Patienten nach DSM-III-R-Kriterien eine schizophrene Störung entwickelt. Die Outcome-Alternative Schizophrenie vs. keine Schizophrenie wurde durch den Unterschied, ob die Betroffenen bei der Indexuntersuchung selbst erlebte Wahrnehmungs-, Denk-, Sprach- und Handlungsstörungen angegeben hatten oder nicht, in 77 % der Fälle korrekt vorhergesagt.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Borderline-Persönlichkeitsstörung ; Impulsivität ; Affektdysregulation ; Experimentelle Affektinduktion ; Dialektisch-behaviorale Psychotherapie ; Key words Borderline personality disorder ; Impulsivity ; Affect dysregulation ; Experimental affect induction ; Dialectical behavioral therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary According to DSM-IV affective instability in borderline personality disorder is due to marked reactions to environmental events. The aim of this study was to investigate affective responsiveness of abnormal personalities with self-harming impulsive behaviors by means of an affect-stimulation design. The first experiment was based on the presentation of a short story that allowed affective responses to various stimuli to be assessed in regard to quality, intensity, and alterations over time. The second one presented a typical frustration design, which provoked specific feelings of anger and disappointment. Impulsive personalities showed an affective hyperreactivity that was characterized by a decreased threshold for affective responses, as well as by intensive, rapidly changing affects. Furthermore, affect experiences turned out to be qualitatively diffuse and undifferentiated. Results support that affective instability of patients with borderline personality disorder should be differentiated from the autonomous deviations of mood typical of affective disorders. Their affective hyperreactivity is a crucial part of impulsive personality functioning.
    Notes: Zusammenfassung Die affektive Instabilität von Patienten mit Borderline-Persönlichkeitsstörung (BPS) wird im DSM-IV einer erhöhten Reaktivität der Stimmungslage auf Umweltereignisse zugeschrieben. Ziel der vorliegenden Studie war es, die affektive Reaktivität von abnormen Persönlichkeiten mit selbstschädigenden Impulshandlungen empirisch mit Hilfe von Affektinduktionsexperimenten zu untersuchen. Das erste Experiment beruhte auf der Präsentation einer Kurzgeschichte und ermöglichte, die Qualität, die Intensität und den zeitlichen Verlauf von affektiven Reaktionen auf vielfältige Reize zu erheben. Das zweite stellte eine typische Frustrationssituation dar, die spezifische Gefühle des Ärgers und der Enttäuschung provozierte. Die impulsiven Persönlichkeiten zeigten eine affektive Hyperreaktivität, die sich als herabgesetzte Affektschwelle, als überhöhte, im Zeitverlauf rasch wechselnde Affektintensität sowie als qualitativ wenig differenzierte Affektantworten manifestierte. Die Ergebnisse legen nahe, daß die affektive Instabilität von Patienten mit BPS von den autonomen Stimmungsauslenkungen affektiver Erkrankungen abgegrenzt werden muß und am ehesten als Teil eines persönlichkeitseigenen impulsiven Stils des Reagierens auf die Umwelt aufzufassen ist.
    Type of Medium: Electronic Resource
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