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  • 1
    Electronic Resource
    Electronic Resource
    Studien zur humoralen Regulation des erythropoetischen Proliferationsspeichers beim Menschen (1978)
    Springer
    Journal of molecular medicine 56 (1978), S. 187-195 
    Details
    ISSN: 1432-1440
    Keywords: Bone marrow clot culture ; Proliferation of the erythropoietic serie ; Mitotic index ; Maturation ; Cell differentiation ; Erythropoietin ; Cobalt ; Iron ; Aetiocholanolone ; cAMP ; folic acid ; Serumfactors ; Polycythämia vera ; Uraemia ; Knochenmark-Koagulumkultur ; Erythroblasten-Proliferation ; Mitoseindex ; Erythroblastenreifung ; Differentialzählung ; Erythropoetin ; Cobalt ; Eisen ; Ätiocholanolon ; cAMP ; Folsäure ; Serumfaktoren ; Polycythämia vera ; Urämie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Beeinflussung der Erythroblasten-Proliferation durch das Mikromilieu wurde in vitro mittels Auswertung durch Differential- und Mitosezählungen und Signifikanzberechnung vieler Versuchsreihen auch unter verschiedenen pathologischen Bedingungen getestet. Sowohl die Mitosehäufigkeit wie die Ausreifung waren positiv mit dem Erythropoetingehalt des Medium korreliert. Der Effekt wurde durch Folsäure, Ätiocholanolon und cAMP verstärkt. Cobalt stimulierte ebenso wie Testosteron und Methenolon in vitro unabhängig von der Erythropoetinkonzentration im Medium die Erythroblastenproliferation. Ein vermindertes Eisenangebot störte die endgültige Ausreifung der Erythroblasten zu Retikulozyten und bewirkte dadurch eine Ineffektivität der Erythorpoese. Anhaltspunkte für ein Erythrozyten-Chalon oder einen Erythropoetinhemmkörper ließen sich aus unserem Versuchsansatz nicht gewinnen, weil er die Transformation der pluripotenten in die erythropoetin-sensible Stammzelle nicht einschließt. Als Nebenbefund ergab sich eine Stimulation des granulozytopoetischen Proliferationsspeichers durch Serumzusatz zum Medium von Patienten nach akutem Blutverlust und bei Polycythämia vera.
    Notes: Summary The Effects of Various Substances in the Culture Microenvironment on the Proliferation of Erythroblasts in vitro were Studied and Evaluated by differential cell and mitosis counting in normal and pathologic bone marrow. The mitotic frequency and maturation correlated directly with the erythropoietin content of the medium and were potentiated on addition of either folic acid, etiocholanolon or cAMP. However, erythroblast proliferation was stimulated independently of erythropoietin concentration when either cobalt, and androgen or an anabolic substance was added to the medium. An iron-deficient medium prevented the maturation of erythroblasts to reticulocytes, thereby rendering erythropoiesis ineffective. The existence of an erythrocyte chalone or an erythropoietin inhibitor could not be deduced from our experiments since the transformation of pluripotent to erythropoetinsensitive stem cells is not included. A stimulation of the granulopoietic proliferation pool occurred when serum from patients with either polycythemia vera or after acute blood loss was added to the medium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01705382
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  • 2
    Electronic Resource
    Electronic Resource
    The deflector-pickup system: A novel approach to measure online the energy spread of DC ion beams
    Amsterdam : Elsevier
    Nuclear Instruments and Methods in Physics Research Section A: 287 (1990), S. 273-278 
    Details
    ISSN: 0168-9002
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0168-9002(90)91807-N
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  • 3
    Electronic Resource
    Electronic Resource
    Inclusive and exclusive preequilibrium spectra in a model of independently interacting excitons (1987)
    Springer
    The European physical journal 328 (1987), S. 333-350 
    Details
    ISSN: 1434-601X
    Keywords: 24.60.Dr ; 24.60.Gv
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Starting from a previous ansatz ofindependently interacting excitons the more refined model INCLUSIVE INDEX is developed yieldinginclusive preequilibrium proton and neutron spectra. It is shown that three stages are sufficient to describe single- and multi-nucleon emission to all orders of practical importance. By use of recurrence relations the loss of particles and energy due to emission from previous stages is fully accounted for. In order to predict the population of specific residual nuclei the precompound process is reformulated in terms ofexclusive emission spectra. This intricate statistical problem is solved in the EXCLUSIVE INDEX model by algorithms representing the average probability for a specified number of particles not to be emitted but to reach the next stage of nuclear relaxation. Differential excitation probabilities can be calculated for those six nuclei which are populated by the emission of none, one, or two preequilibrium nucleons in two stages via alltogether 15 principal paths. Typical features of the INCLUSIVE and EXCLUSIVE INDEX model are discussed. The strength of one- and two-nucleon emission is compared with HYBRID model predictions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01290502
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  • 4
    Electronic Resource
    Electronic Resource
    Analysis of excitation functions from light ion induced reactions in the EXCLUSIVE INDEX model (1989)
    Springer
    The European physical journal 333 (1989), S. 415-415 
    Details
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01299700
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  • 5
    Electronic Resource
    Electronic Resource
    Analysis of inclusive nucleon spectra fromp- andα-induced reactions in the frame of the INDEX model, and implications for stopped π−-induced reactions (1987)
    Springer
    The European physical journal 328 (1987), S. 445-453 
    Details
    ISSN: 1434-601X
    Keywords: 24.60.Dr ; 24.60.Gv ; 25.80.Ls
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The previously published INDEX model is tested for nucleon spectra fromp- andα-induced reactions. The results of two alternative versions, the INCLUSIVE INDEX model and the EXCLUSIVE INDEX model, quite well agree with the data. It is found that in the INCLUSIVE INDEX model three preequilibrium stages are sufficient to describe single- and multi-nucleon emission. The model provides an useful first order estimate of the influence of the finite Fermi energy on particle spectra. This effect is very strong for nucleon induced reactions while forα-induced reactions it can be neglected. The deduced mean-free-path multiplier corroborates the long stated discrepancy between models in which excitons interact independently or not. Using preequilibrium parameters similar to those found for nucleon induced reactions the important branching ratio of contributingnp andpp pairs in stoppedπ −-absorption can be determined by INDEX model calculations. Deduced values from publishedn- andp-spectra agree reasonably well with those of other experimental analyses but deviate significantly from microscopic model predictions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01289630
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  • 6
    Electronic Resource
    Electronic Resource
    Analysis of excitation functions from light ion induced reactions in the EXCLUSIVE INDEX model (1989)
    Springer
    The European physical journal 333 (1989), S. 45-56 
    Details
    ISSN: 1434-601X
    Keywords: 24.60.Dr ; 24.60.Gv ; 25.40.−h ; 25.45.−z ; 25.55.−e ; 25.70.Gh
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The previously introduced EXCLUSIVE INDEX model allows to predict the population of 6 residual nuclei including the primary compound nucleus through two stages of the preequilibrium phase. The present version is limited to maximum two-nucleon emission. The preequilibrium ejectiles may reduce the brought-in rotational energy by a model of maximum angular momentum decoupling. Subsequent evaporation of protons, neutrons andα-particles is treated in the frame of the Weisskopf-Ewing ands-wave approximation considering pairing effects only in compound nucleus state densities. The sensitivity of essential preequilibrium parameters on the shape of calculated excitation functions is tested. The model predictions well compare to excitation functions fromp, d,3He and4He induced reactions including the large set from the reaction93Nb(4He,xn yp) up to 170 MeV bombarding energy. The general importance of two-nucleon preequilibrium emission is accentuated in several examples. The deduced preequilibrium parameters corroborate the results from the INDEX model analysis of nucleon spectra.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01290109
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