Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    ISSN: 1432-1076
    Keywords: Key words: Beta-endorphin – Cerebrospinal fluid – Nucleus tractus solitarius – Sudden infant death
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. In nucleus tractus solitarius (NTS) beta-endorphin (BEND) induces bradycardia and respiratory depression which have been reported to precede death in sudden infant death (SID). Of SID victims, 50% have elevated levels of beta-endorphin immunoreactivity (BENDI) in the cerebrospinal fluid (CSF), and 50% had undetectable levels. We therefore investigated the relationship of BENDI in the CSF to BENDI levels in the NTS area. This study included SID victims (CSF from n=47, brain stem from n=16), borderline SID victims (CSF and brain stem from n=2), sudden death in childhood (CSF and brain stem from n=1), and controls (CSF from n=32, brain stem from n=11). BEND in CSF and NTS area, after extraction, was measured by radioimmunoassay. High performance liquid chromatography was used for closer identification of BENDI. We found that the SID victims divided into two subpopulations, one having a relatively high BENDI level in CSF and one having no detectable level (P〈0.01). Furthermore, an inverse relationship was found between BENDI level in CSF and BENDI level in NTS area in the SID victims (P〈0.05). We conclude that increased BENDI level in CSF is associated with low BENDI level in the NTS area in 50% of SID victims. The low BENDI level in the NTS area may be due to increased release of BEND.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1432-1076
    Keywords: Beta-endorphin ; Hypoxanthine ; Hypoxia ; SID
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Beta-endorphin (BEND) may induce respiratory depression. Elevated levels of beta-endorphin immunoreactivity (BENDI) in the CSF are found in children with apnoea and in about 50% of sudden infant death (SID) victims. Premortal hypoxia in SID victims has been indicated by elevated hypoxanthine (HX) levels in the vitreous humour (VH). In this study we correlated BENDI in CSF with HX in VH in SID victims (n=19) and controls (n=18). BEND in CSF was measured by RIA, and HPLC was used for identification of BENDI. HX in VH was measured by HPLC. All the SID victims had elevated levels of HX in VH. The BENDI in CSF divided the SID victims into two subpopulations (P〈0.01); one with undetectable levels (〈4.3 fmol/ml) (n=10) and one with high levels (160–400 fmol/ml) (n=9).In the SID subpopulation with high levels of BENDI in CSF,we found a correlation between BENDI in CSF and HX in VH (r=0.92). Control infants who died a stressful death, such as during heart operations (n=2), had high levels of BENDI in CSF and low levels of HX in VH. Controls who died of infections (n=11) had low levels of BENDI in CSF and elevated levels of HX in VH. Because hypoxia in itself does not increase BENDI in CSF, increased BENDI in CSF is probably not secondary to hypoxia but may be of aetiological significance. We therefore suggest that SID victims with high levels of BENDI in CSF, which correlate with the elevated levels of HX in VH, may die from premortal hypoxia possibly induced by BEND.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 1432-1076
    Keywords: Key words     Beta-endorphin ; Brain stem gliosis ; Corpus vitreous ; humour ; Cerebrospinal fluid ; Sudden infant death
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract      Beta-endorphin may induce respiratory depression and bradycardia. Elevated levels of hypoxanthine (HX) in vitreous humour (VH) may possibly indicate hypoxia before death. Furthermore, gliosis in the brain stem may reflect a previous hypoxic/ischaemic injury in the brain. In the present study we relate beta-endorphin immunoreactivity (BENDI) in the CSF to the presence or absence of reactive astrocytosis in the nucleus olivae inferior (NOI). The relationship between the HX concentration in VH and the number of reactive astrocytes in sudden infant death (SID) cases (n = 17) and controls (n = 23) was also studied. The number of reactive astrocytes was examined in the NOI by immunohistochemical demonstration of glial fibrillary acidic protein (GFAP). The BENDI in CSF and the number of reactive astrocytes in the NOI divided the SID victims into two subpopulations (P 〈 0.01). One had a median of 〈 4 fmol/ml BENDI in CSF (range 〈 4) and 2 reactive astrocytes (range 0–15), and was similar to the controls that died from infections. The other subpopulation had a median of 260 fmol/ml BENDI in CSF (range 160–400) and 13 reactive astrocytes (range 7–33), similar to the control infants with previous hypoxia. In this latter SID subpopulation the number of reactive astrocytes correlated positively with BENDI in CSF (r = 0.7, P 〈 0.05). All the SID victims had elevated levels of HX in VH. In the SID subpopulation with high level of BENDI in CSF and increased number of activated astrocytes, the correlation factor between HX in VH and activated astrocytes was r = 0.7 (P 〈 0.05). Conclusion     When investigating reactive astrocytes and BENDI in CSF in SID victims, 50% of the SID victims were similar to the controls with previous hypoxia and the other 50% similar to the controls who died from infections.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/General Subjects 798 (1984), S. 350-360 
    ISSN: 0304-4165
    Keywords: (Rat liver) ; Adrenergic stimulation ; Glycogenolysis ; Hypothyroidism
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Free Radical Biology and Medicine 9 (1990), S. 174 
    ISSN: 0891-5849
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Molecular Cell Research 885 (1986), S. 206-215 
    ISSN: 0167-4889
    Keywords: (Rat liver cell) ; Ca^2^+ concentration ; Thyroid hormone ; Vasopressin stimulation ; α"1-Adrenergic stimulation
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Molecular Cell Research 846 (1985), S. 275-285 
    ISSN: 0167-4889
    Keywords: (Rat liver) ; Ca^2^+ mobilization ; Glycogenolysis ; Thyroid hormone ; Vasopressin stimulation ; α"1-Adrenergic stimulation
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 313 (1965), S. 668-671 
    ISSN: 1435-2451
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 82 (1959), S. 548-559 
    ISSN: 1432-1076
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Die Normalwerte der MDH liegen auch im Kindesalter zwischen 1–7 E, die der SGOT und der SGPT zwischen 10 und 40 E. Findet man Fermentaktivitäten zwischen 40 und 50 E, so handelt es sich um Grenzwerte, die einer Wiederholung bedürfen. Für die Neugeborenen- und Säuglingsperiode gelten im Prinzip die gleichen Normalwerte. Die MDH und die SGOT liegen allerdings an der oberen Grenze des Normbereiches. Die SGOT sollte jedoch auch bei diesen Kindern 50 E nicht überschreiten. Auch für das Kindesalter hat sich die Bestimmung der Transaminasen zur Verlaufsbeurteilung der Hepatitis als sehr empfindlicher Test erwiesen, der alle Schwankungen im Krankheitsverlauf genau anzeigt. Zur Abgrenzung verschiedener Ikterusformen im Neugeborenen- und Säuglingsalter liegen bisher noch keine ausreichenden Erfahrungen vor. Doch sprechen einige Befunde dafür, daß auch hier die Bestimmung der Fermentspiegel in differentialdiagnostischer Hinsicht eine Bedeutung erlangen wird.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 315 (1973), S. 164-174 
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Durch Cyclisierung von 1-Acyl-4-benzoyl-selenosemicarbaziden werden 2-Benzamino-1,3,4-selenadiazole erhalten, deren Hydrolyse zu 2-Amino-1,3,4-selenadiazolen führt. Aus 1-Acyl-4-aryl(alkyl)-selenosemicarbaziden bilden sich in entsprechender Weise 2-Aryl-(Alkyl)-amino-1,3,4-selenadiazole.
    Additional Material: 5 Tab.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...