ISSN:
1432-1041
Keywords:
Theophylline
;
Verapamil
;
drug interaction
;
healthy volunteers
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary Results of previous studies suggest that the theophylline-verapamil drug interaction may be dependent on verapamil dose. Therefore, in a randomized four-way cross over study, 12 healthy males received theophylline, as a single intravenous dose of aminophylline, alone (phase I) and after a four day regimen of oral verapamil 40 mg (phase II), 80 mg (phase III), and 120 mg (phase IV) every 8 h. Serial blood samples were collected over a 24 hour period for determination of serum theophylline concentration and subsequent pharmacokinetic analysis. Mean theophylline AUC for phase I–IV was 93.6, 105.6, 110.8, 120.1 mg · h · l−1, respectively. Mean theophylline clearance for phase I–IV was 3.89, 3.59, 3.35, and 3.20 l · h−1, respectively. The changes in AUC, clearance, andλ z were linearly correlated to verapamil dose. These results suggest that the inhibitory effect of verapamil on the pharmacokinetic disposition of theophylline is directly related to verapamil dose.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02280751
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