ISSN:
1432-1912
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The lethal dose of g-strophanthine and thevetine B was determined by infusion experiments with various infusion speeds in guinea pigs. In 71 experiments with g-strophanthine and 64 experiments with thevetine B a functional relationship between the lethal dose and infusion speed was established by means of statistical methods. The LD/speed function was characterized by a range of overtitration (rapid infusions), by a flat minimum with a practically constant LD and by a range with an increasing LD with decreasing infusion speed (influence of elimination). The optimal infusion time (Topt) and optimal infusion speed (Vopt) for a maximal utilization of glycoside resulted in a minimal value of LD (LDmin) and could be numerically determined by graphical evaluation of the established LD/speed function. These values were for g-strophanthine: Topt=31,8 min, Vopt=0,0063 mg/kg/min, LDmin:0,20 mg/kg. For thevetine B: Topt=22,7 min, Vopt=0,133 mg/kg/min, LDmin : 3,02 mg/kg. From the parameters of the LD/speed and the LD/time function the values for the fixation and detoxification constants of both glycosides were calculated. With thevetine B there was a striking correlation between the clinically observed rapid onset of action and the high value of the fixation constant.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00246587
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