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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Diabetologia 9 (1973), S. 367-375 
    ISSN: 1432-0428
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The clinical and immunological findings are described in a female newborn infant who presented with hypoglycemia associated with a high titre of an insulin-binding protein in her serum. The insulin-binding protein belonged to IgG, the light chain of which consisted solely of Kappa-type. The other properties of the insulin-binding protein were very similar to those of insulin antibodies produced by insulin injection, except for a stronger affinity to human insulin as compared with bovine insulin. The patient's mother had a similar protein in her serum despite no previous history of insulin treatment. It is assumed that the hypoglycemia of this patient might have been due to the presence of the antibody produced in her mother's body against endogenous insulin and transferred to the patient transplacentally.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0568
    Keywords: Key words Intramembranous ossification ; Immunohistochemistry ; Muscle fiber type
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Previous studies using parathyroid hormone-related protein (PTHrP) null mutant mice have indicated severe abnormalities in the endochondral ossification, suggesting that PTHrP affects chondrocyte differentiation. In this study, we found in newborn PTHrP-deficient mice some deformities in the mandible that is formed via intramembranous ossification. The mandibular ramus was bent downwards and a prominent bone crest to which the deep layer of masseter muscle was tendinously attached was observed in the mandibular body. Transmission electron microscopic studies showed that active bone formation was progressing along the tendon fibers of the masseter muscle. The examination of 3-D reconstruction models indicated that the mandibular ramus was bent at the site of muscle attachment, which was shifted in the direction of the muscle fibers. Muscle fiber type analysis using myosin ATPase staining showed that the masseter muscle in the newborn PTHrP-deficient mice contained numerous type 2B fibers, demonstrating premature maturation of this muscle. Based on these findings, we speculated that premature maturation of the masseter muscle leads, probably due to increased tensile forces, to accelerated bone crest formation and subsequent bending of the mandibular ramus. These results further suggest that PTHrP is involved in the regulation of muscle development in normal animals.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Free Radical Biology and Medicine 9 (1990), S. 121 
    ISSN: 0891-5849
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Chemical Physics Letters 55 (1978), S. 383-385 
    ISSN: 0009-2614
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 77 (2000), S. 2494-2496 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Photorefractive damage, photoconductivities, and photogalvanic currents of LiNbO3 single crystals have been investigated as a function of [Li]/[Nb] and MgO concentrations. Near stoichiometric LiNbO3 single crystal, having large [Li]/[Nb] ratios of 0.993, shows lower photorefractive damage resistance than congruent LiNbO3. However, crystals doped with a small amount of MgO (〉0.78 mol %) exhibit no measurable photorefractive damage at 532 nm to intensities of as much as 2 MW/cm2. This remarkable decrease of photorefraction that was found can be attributed to the decrease of saturated space charge field results from a combination of the increased photoconductivity and the decreased photogalvanic current of the crystal. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/General Subjects 1157 (1993), S. 318-323 
    ISSN: 0304-4165
    Keywords: Active oxygen ; Bone Resorption ; Differentiation ; Osteoclast
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Physics of the Earth and Planetary Interiors 73 (1992), S. 38-52 
    ISSN: 0031-9201
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Geosciences , Physics
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Physics Letters 22 (1966), S. 293-295 
    ISSN: 0031-9163
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Pflügers Archiv 439 (2000), S. 555-558 
    ISSN: 1432-2013
    Keywords: Ca2+-induced Ca2+ release Caffeine Dihydropyridine receptor Excitation–contraction coupling Ryanodine receptor Skeletal muscle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Patch-clamping and the simultaneous fluorescence measurement of cytoplasmic Ca2+ ([Ca2+]i) were used to analyze the effect of serum on the functional features of excitation–contraction (E–C) coupling in mouse skeletal myotubes. In high-serum-treated (10%) myotubes, depolarization elicited Ca2+ release which continued for tens of milliseconds following the end of the pulse, after which [Ca2+]i decayed slowly. In low-serum-treated (0.5%) myotubes, the Ca2+ transient caused by depolarization had an increased rate of rise and peak amplitude, and [Ca2+]i began to decay rapidly upon repolarization. When a depolarizing pulse (0.5–1.0 s) was applied to low-serum-treated myotubes during a Ca2+ transient induced by 5–10 mM caffeine, repolarization usually caused the caffeine transient to terminate rapidly (RISC; repolarization-induced stop of caffeine-induced Ca2+ release). The RISC was less prominent in high-serum-treated myotubes. These results suggest that low serum promotes the maturation of myotubes so that Ca2+-release and Ca2+-removal activities are accelerated. Additionally, the essential features of the communication between the voltage sensor and the Ca2+-release channel are shared by myotubes and adult muscle fibers.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-2013
    Keywords: Key words Skeletal muscle ; E-C coupling ; Ryanodine receptors ; Calcium-induced calcium release ; Caffeine ; Cardiac muscle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  We have combined the patch-clamp technique with Fura-2 measurements to investigate whether RISC (repolarization-induced stop of caffeine-contracture) is a consequence of store depletion in cultured skeletal muscles of rats and mice. Weak depolarizations (–45 to –40 mV) of long duration induced a barely detectable Ca2+ transient. Even under these conditions, caffeine-activated Ca2+transients (CafTs) were terminated upon membrane repolarization (–70 mV) at all stages of CafT. Following the peak of the CafT, massive Ca2+ release was elicited by either flash-photolysis of caged Ca2+ or further depolarization to 0 mV, demonstrating the lack of store depletion. Thus, RISC is not due primarily to store depletion but to closure of the Ca2+ release channels possibly through a mechanical interaction with voltage sensors. RISC was not present in rat heart muscle, further supporting a role of direct interaction in skeletal muscle.
    Type of Medium: Electronic Resource
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