ISSN:
1432-2072
Keywords:
Conditioned taste aversion
;
Drug pre-exposure
;
Morphine
;
Diazepam
;
Δ9-tetrahydrocannabinnol
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Prior to taste aversion conditioning with morphine, diazepam or Δ9-tetrahydrocannabinnol (Δ9-THC), rats received pre-exposures to the vehicle or one of the three drugs. Morphine pre-exposures blocked the aversion normally induced by morphine, but not by Δ9-THC or diazepam. Diazepam pre-exposures attenuated both the morphine- and diazepam-induced taste aversions to a significantly greater degree than the taste aversion induced by Δ9-THC. As a result of Δ9-THC pre-exposures, the aversions induced by diazepam and Δ9-THC were attenuated as well as the morphine-induced aversion, which was the most greatly attenuated. These results demonstrate that pre-exposure effects are not necessarily bi-directional and, moreover, they are inconsistent with current hypotheses which attempt to account for the attenuating effect of drug pre-exposures on taste-aversion conditioning.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00432682
Permalink