Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    ISSN: 0268-2605
    Keywords: organotin ; N-(2-pyridylmethylene)arylamines ; IR ; NMR ; Mössbauer ; mutagenicity ; sister chromatid exchange ; cell cycle delay ; bone-marrow cells ; Chemistry ; Industrial Chemistry and Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Diorganotin(IV) dichloride complexes of the type R2SnCl2·L (R = methyl, ethyl, vinyl, t-butyl, n-butyl or phenyl; L = N-(2-pyridylmethylene)arylamine) have been synthesized and characterized on the basis of IR, NMR and 119Sn Mössbauer studies. Investigation of the complexes indicated that N-(2-pyridylmethylene)arylamines form distorted trans-octahedral complexes with R2SnCl2 similar to the well-known R2SnCl2·L. Cytogenetic toxicology testing has been performed for Et2SnCl2·L4 [L4 = N-(2-pyridylmethylene)-4-toluidine] in mouse bone-marrow cells in vivo since such testing is a regulatory requirement before new drugs are released. This tin compound induced delay in cell-cycle kinetics and sister chromatid exchanges (SCEs) significantly. The effect of Et2SnCl2·L4 was greater when endogenous glutathione (GSH) was depleted by buthionine sulphoximine (BSO). It seems that Et2SnCl2·L4 induces SCEs due to formation of adduct by binding on DNA which could interfere in DNA synthesis and cause delay in cell proliferation. Depletion of GSH could reduce the shielding effect of GSH on chromatin and allows more Et2SnCl2·L4 to bind on DNA. © 1998 John Wiley & Sons, Ltd.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...