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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Inflammation research 44 (1995), S. 222-226 
    ISSN: 1420-908X
    Keywords: Immunity ; Type II collagen ; Proteoglycan ; Osteoarthritis ; Mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We measured immunity to type II collagen and proteoglycans in osteoarthritic C57BL mice to determine whether it is related to osteoarthritis pathogenesis. Histological examination revealed articular cartilage lesions in all mice and synovitis in only a few mice. Immunological responses to type II collagen were found in collagen arthritic mice, but not in C57BL mice. Furthermore, immunological responses to proteoglycans were observed in proteoglycan-immunized mice, but not in C57BL mice. Therefore, articular cartilage degeneration may not result in autoimmunity to type II collagen and proteoglycans in osteoarthritis of C57BL mice, and immune responses to these components may not be a primary etiology of osteoarthritis in this model.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Inflammation research 44 (1995), S. 79-82 
    ISSN: 1420-908X
    Keywords: Collagen ; Arthritis ; Cyclosporin and hyaluronan
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Serum hyaluronan (HA) levels were measured in a rat model of collagen arthritis using a sandwich enzyme-linked immunosorbent assay. Values became elevated as the arthritis developed, correlating with its severity. Daily subcutaneous treatment with cyclosporin at the dose of 25 mg/kg per day for fourteen days completely prevented anti-type II collagen antibody production and the serum HA increase as well as development of collagen arthritis. HA in the blood may thus provide a good quantitative marker for joint disease in rat collagen arthritis with potential as a tool for evaluation of drug efficacy in this experimental model.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 229 (1971), S. 31-33 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We now describe the results of further analysis of the data obtained in the same flight and the succeeding flight by the rocket, S-210, launched on the next day from the same place. We took special care in the fabrication and calibration of the X-ray detectors, and in the aspect analysis of the ...
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 224 (1969), S. 784-785 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Our instrument was composed of two proportional counters (A and B) filled with Xe-methane gas at 330 mm Hg. The depth of the counter was 5 cm and the effective area of each 110?m Be window was 40 cm2. Each counter had cellular collimators and was shielded by veto-counters to reduce spurious counts. ...
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Human genetics 〈Berlin〉 53 (1979), S. 37-41 
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Four cases from two families with dermatan sulfate mucopolysacchariduria who lack α-L-iduronidase in peripheral leukocytes are described. The clinical and roentgenographic features of these cases represent an intermediate phenotype between Hurler's syndrome and Scheie's syndrome, and both parents in each family are first cousins. In the presence of parental consanguinity, a phenotypic variation or a third mutant allele at the iduronidase locus seems to be a more reasonable explanation for these cases than a genetic compound.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Skeletal radiology 9 (1982), S. 47-51 
    ISSN: 1432-2161
    Keywords: Osteopetrosis ; Intermediate form ; Recessive inheritance ; Avascular necrosis of the femoral head
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The clinical and radiographic features of the intermediate form of osteopetrosis in two sibs are presented in which the disorder appears to have been inherited as a recessive trait. Although this form of osteopetrosis has been poorly delineated, its recognition is practically important in order to give an accurate prognosis. This paper also presents an unusual complication of bilateral avascular necrosis of the femoral head in the younger sib. Radiographic changes of the femoral heads suggest those of Legg-Calvé-Perthes disease, though the possibility of avascular necrosis following unrecognized femoral neck fracture is not completely excluded.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Skeletal radiology 10 (1983), S. 13-16 
    ISSN: 1432-2161
    Keywords: Bone dysplasia ; Spine ; Epiphysis ; Hand ; Progressive arthropathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The clinical and roentgenographic manifestations of six cases suffering from spondyloepiphyscal dysplasia tarda with progressive arthropathy are presented. The roentgenographic features consist of generalized platyspondyly and varying degrees of epiphyseal involvement with conspicuous enlargement of both ends of the short tubular bones of the hands. This disorder appears at an earlier age, and is more crippling than the usual form of spondyloepiphyseal dysplasia tarda. It is suggested that orthopaedic measures are essential for all patients with this disorder, as profound disability may be expected by progressive involvement of the major joints.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-2161
    Keywords: Bone dysplasia ; Enchondromatosis ; Dyschondroplasia ; Soft tissue calcification ; Hemangioma ; Maffucci syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Generalized enchondromatosis is a newly delineated type of enchodromatosis. Radiographically there are multiple enchondromata in almost all metaphyses of the long and short tubular bones and the lesions are in almost the same stage of development with mild platyspondyly and skull deformity. The pelvic changes are characteristic and, together with the metaphyseal changes of the long and short tubular bones, are probably diagnostic of this disorder. The present case demonstrates advanced radiographic features of this disorder associated with unusual soft tissue calcifications and hemangiomas. The presence of hemangiomas in our case as well as three cases in the literature suggests this feature is more than a coincidence.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-2161
    Keywords: Key words Ultrasonography ; Surgery ; Shoulder ; Rotator cuff ; Tear
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  In this study the clinical usefulness of ultrasonography in the diagnosis of rotator cuff tears was assessed. One hundred twenty-two patients undergoing preoperative ultrasonography were evaluated surgically. Three different ultrasonographic machines were applied with a 7.5-MHz linear-array transducer. Surgery confirmed a sensitivity of 79% for full-thickness tears and 50% for partial thickness tears. In 73 patients with negative ultrasonographic findings, the specifity was 100% for full-thickness tears and 90% for partial-thickness tears. The diagnostic sensitivity for full-thickness tears of the Hitachi EUB-340 system was significantly lower than those of Hitachi EUB-415 and EUB-515, and thus the former cannot be recommended for detection of rotator cuff tears. The sensitivity with regard to partial-thickness tears was also significantly lower with the Hitachi EUB-340 system as compared to the Hitachi EUB-515. There were no significant differences in false-positive rate among the three machines used. In conclusion, accurate ultrasonographic diagnosis of rotator cuff tear requires a high-resolution machine, as well as considerable experience in interpretation.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Astrophysics and space science 42 (1976), S. 223-244 
    ISSN: 1572-946X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The short-term X-ray variability distinguishes Cyg X-1, which is the most likely candidate for a black hole, from other X-ray sources. The present status of our knowledge on this short-term variation, mainly from the UHURU, the MIT and the GSFC observations, is reviewed. The nature of impulsive variations which compose the time variation exceeding the statistical fluctuation is discussed. There are indications that the energy spectrum of large pulses is harder than the average spectrum, or that the large pulses are the characteristics of the hard component of the spectrum if it is composed of two, soft and hard, components. Features of the variations may be partly simulated by the superposition of random shot-noise pulses with a fraction of a second duration. However, the autocorrelation analysis and the dynamic spectrum analysis indicate that the correlation lasts for several seconds and in the variation are buried some regularities which exhibit power concentrations in several frequency bands; 0.2–0.3, 0.4–0.5, 0.8, 1.2–1.5 Hz. There are several possible interpretations of these results in terms of; e.g. (a) a mixture of shot-noise pulses with two or more constant durations, (b) the shape of the basic shot-noise pulse, (c) bunching of the pulses, (d) superposition of wave-packets or temporal oscillations. But we have not yet reached any definite understandings in the nature of the variabilities. The substructure of the fluctuations on a time scale of milliseconds suggested by two investigations is also discussed.
    Type of Medium: Electronic Resource
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