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  • 1
    Electronic Resource
    Electronic Resource
    Determination of bradykinin-(1–5) in inflammatory exudate by a new ELISA as a reliable indicator of bradykinin generation (1996)
    Springer
    Inflammation research 45 (1996), S. 416-423 
    Details
    ISSN: 1420-908X
    Keywords: Enzyme-linked immunosorbent assay (ELISA) ; Bradykinin-(1–5) ; Carageenin-induced pleurisy ; Nasal allergy ; Kinin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have developed an ELISA for BK-(1–5) (Arg1-Pro2-Pro3-Gly4-Phe5). In rat carrageenin-induced pleurisy, in which a plasma exudation peak was observed 5 h after carrageenin, BK levels in the exudates were negligible (〈60 pg/rat). BK-(1–7) (des-Phe8-Arg9-BK) was detectable (900–400 pg/rat) over the entire course of the inflammation. However, a larger amount of BK-(1–5) was detectable in association with the increase in plasma exudation, showing a peak (8800±1200 pg/rat) 3 h after carrageenin. Bromelain (10 mg/kg, i.v.) and soy bean trypsin inhibitor (0.3 mg/rat, intra-pleural) significantly reduced BK-(1–5) levels (by 60–93%, 3, 7 and 19 h after carrageenin) and plasma exudation rates (by 61–74%, 3 and 7 h after carrageenin). Dexamethasone (0.3 mg/kg, i.p.) reduced BK-(1–5) levels (by 78%) and decreased plasma exudation (by 70%) 3 h after carrageenin. In nasal allergy patients, antigen challenge of nasal mucosa elevated BK-(1–5) levels and active kallikrein levels in nasal washes. These results verify that BK-(1–5) determined by ELISA is a good indicator for release of kinins in vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02252938
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  • 2
    Electronic Resource
    Electronic Resource
    Coxsackie B antigen in the central nervous system of a patient with fatal acute encephalitis: immunohistochemical studies of formalin-fixed paraffin-embedded tissue (1990)
    Springer
    Acta neuropathologica 80 (1990), S. 216-221 
    Details
    ISSN: 1432-0533
    Keywords: Central nervous system ; Coxsackie B virus ; Encephalitis, viral ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A case of fatal acute encephalitis due to Coxsackie B1 virus is described. Confirmation of Coxsackie B virus as the etiological agent of encephalitis was based on identification of the virus antigen in formalin-fixed paraffin-embedded tissue sections. In the past, the diagnosis was obtained by serological studies of peripheral blood and viral isolation. This is the first report in which indirect immunofluorescent and immunoper-oxidase methods using rabbit antiserum raised against Coxsackie B types 1–6 was utilized in determining the etiology of encephalitis. It must be emphasized that these methods can be used both on biopsy or autopsy specimens, even retrospectively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00308928
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  • 3
    Electronic Resource
    Electronic Resource
    Intraventricular neuroblastoma in a patient with Von Hippel-Lindau's disease (1981)
    Springer
    Acta neuropathologica 53 (1981), S. 253-256 
    Details
    ISSN: 1432-0533
    Keywords: Neuroblastoma ; Phakomatosis ; Von Hippel-Lindau's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cerebral neuroblastoma is a rare neoplasm that has not previously been associated with a phakomatosis. We report a case of an intraventricular neuroblastoma in a patient with Von Hippel-Lindau's disease. The neoplasm consisted of process-forming cells containing clear vesicles, dense-cored granules and microtubules. An unusual finding was the presence of intertwining cytoplasmic processes, apparently representing aberrant process formation. We suggest that this case represents a cerebral neuroblastoma occurring as an unusual manifestation of a phakomatosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688029
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  • 4
    Electronic Resource
    Electronic Resource
    Delayed-type skin reaction to 2,4-dinitrophenylated epidermal cells in guinea pigs with contact sensitivity to 2,4-dinitrochlorobenzene (1987)
    Springer
    Archives of dermatological research 279 (1987), S. 236-240 
    Details
    ISSN: 1432-069X
    Keywords: 2,4-Dinitrochlorobenzene (DNCB) ; Contact sensitivity ; Epidermal cell ; Delayed-type skin reaction ; Langerhans cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Contact sensitivity (CS) induced by hapten has been thought to be analogous to delayed-type hypersensitivity, such as the Mantoux reaction, because of outstanding similarities between the two phenomena. It can be suggested that animals with CS respond also to intradermal injection of the conjugate of hapten and protein as well as to epicutaneous application of hapten. However, evidence against this has been reported. In the present experiments, delayed-type skin reaction (DSR) was successfully obtained in JY1 strain guinea pigs sensitized by painting the skin with 2,4-dinitrochlorobenzene using in vitro dinitrophenylated epidermal cell suspension (DNP-EC) as antigen for a delayed intradermal test. The experiment using anti-Ia alloantiserum and complement showed that the elicitation of DSR is due to the presence of Ia-positive cells (presumably Langerhans cells) among DNP-ECs. The delayed intradermal test with the conjugates such as haptenated ECs in the animals with CS is considered to be an experimentally useful way of analysing the antigen in the sensitivity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00417321
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  • 5
    Electronic Resource
    Electronic Resource
    Histological study on the fate of haptenated epidermal cells injected intradermally in guinea pigs (1987)
    Springer
    Archives of dermatological research 279 (1987), S. S111 
    Details
    ISSN: 1432-069X
    Keywords: 2,4-Dinitrochlorobenzene ; 2,4-Dinitrophenylated epidermal cells ; Contact sensitivity ; Spontaneous flare ; Delayed-type skin reaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The percutaneous administration of in vitro haptenated epidermal cells (EC) has become established as a procedure to produce contact sensitivity (CS) in experimental animals for routine use. The cells have also been found to elicit a significant delayed-type skin reaction by intradermal test in the animals sensitized by painting the skin with the hapten. The fate of 2,4-dinitrophenylated (DNP) isogeneic epidermal cell suspensions (EC) injected intradermally was investigated histologically in intact or 2,4-dinitrochlorobenzene (DNCB)-sensitized strain 13 guinea pigs to study the role of the cells in CS. DNP-EC were found to proliferate actively in the dermis and formed EC nests with central keratinization and then elicited inflammatory reaction associated with necrosis of the epidermal structures 7 days after injection in the intact animals. DNP-EC injected intradermally into the animals which had received and reacted against DNCB underwent a suppression of EC proliferation. These findings are discussed in relation to the role of the haptenated EC in CS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00585933
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  • 6
    Electronic Resource
    Electronic Resource
    Circular trajectory formation during blind locomotion: a test for path integration and motor memory (1997)
    Springer
    Experimental brain research 115 (1997), S. 361-368 
    Details
    ISSN: 1432-1106
    Keywords: Key words Path integration ; Motor systems ; Locomotion ; Spatial memory ; Circular trajectories
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Eight healthy subjects were asked to walk blindfolded along circular paths of different radii after several practice trials with vision. Their task was to stop after completing two full revolutions. They always walked counter-clockwise (CCW) in (a) a control condition (CONTROL), including the instructions mentioned above, (b) with the further instruction to count backwards in twos (MENTAL), (c) with the instruction to count loudly (LOUD). The movement of two markers lying along the head naso-occipital axis was recorded by means of an ELITE system. Total walked distance (DISTANCE), total head turning angle (ANGLE) and average radius (RADIUS) of the trajectories performed were measured. All subjects were able to perform approximately circular trajectories. They consistently overshot the ideal radius independently of the condition and circle size, undershot the total angle and overshot total distance. The LOUD condition induced greater errors in the performance but only on total distance (P〈0.05). A strong correlation was found between the errors in radius and total distance but not between distance and total angle. Principal components analysis suggested that radius and distance share a common source of errors while total angle produced independent errors. The results indicate that (a) circular trajectories can be generated starting from spatial and/or motor memory, without the aid of visual information; (b) the task needs some attentional control and does not involve simple automatic processing of afferent information; (c) different sensory information or different processing modes are probably involved in the estimation of the curvature and length of the walked path on the one hand, and of the total rotation angle on the other.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00005705
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  • 7
    Electronic Resource
    Electronic Resource
    The effects of prazosin and propranolol in combination with thiazide diuretics on blood pressure and serum lipids: a multicentre study (1987)
    Springer
    European journal of clinical pharmacology 33 (1987), S. 339-344 
    Details
    ISSN: 1432-1041
    Keywords: prazosin ; propranolol ; hypertension ; antihypertensive effects ; lipid metabolism ; multicentre study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We have carried out randomized 12-week multicentre study to compare the effects of prazosin and propranolol on blood pressure and serum lipids in 70 patients with essential hypertension after a 4 week minimum period of treatment with thiazide diuretics. After 12 weeks treatment with prazosin (n=40, 1.5–12.0 mg per day) or propranolol (n=30, 30–120 mg per day) with diuretics there was a significant blood pressure reduction from 165.1/97.9 mmHg to 151.2/90.6 mmHg and from 167/96.5 mmHg to 153/91.9 mmHg, respectively. In the 12th week a significant decrease was noted in triglyceride and in low-density lipoprotein cholesterol (LDL + VLDL-C), but no significant effects were seen in high-density lipoprotein cholesterol (HDL-C) in patients receiving prazosin. On the other hand, a significant decrease in lecithin cholesterol acyltransferase (LCAT) was seen in patients receiving propranolol. Twenty-six of 40 patients receiving prazosin were given an additional 12 weeks of treatment. Twenty-two of 30 patients initially treated with propranolol were switched from propranolol to prazosin after 13 weeks and given prazosin up to the 24th week. At 24 weeks, the blood pressure was 149/93.0 mmHg in the prazosin group and 155/89.2 mmHg in the group which switched from propranolol to prazosin. Triglyceride remained reduced in the prazosin group at the 24th week. In the group which switched from propranolol to prazosin, triglyceride decreased significantly over the next 12 weeks.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00637627
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  • 8
    Electronic Resource
    Electronic Resource
    Gangliocytoma of the pineal body a case report and review of the literature (1985)
    Springer
    Acta neurochirurgica 74 (1985), S. 134-140 
    Details
    ISSN: 0942-0940
    Keywords: Gangliocytoma ; pineal body ; “sea lion” position (operative position) ; CT ; brain scintiscan
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ganglion cell tumours are mostly seen in children and young people, but they are extremely rare, accounting for 0.1–0.5% of all brain tumours. It usually occurs in the floor of the third ventricle and the temporal lobe. Recently we have experienced a pineal gangliocytoma, probably the first ever seen in Japan and the fourth case in the world, and have succeeded in a total removal of it. The case concerns a 51-year-old man who sufferend from intermittent blurred vision and headache of 3 years' duration. CT showed, together with severe hydrocephalus, positive contrast medium enhancement and a somewhat irregular but sharply circumscribed high density lesion suggestive of a meningioma. But the brain scintiscan revealed a badly and irregularly demarcated region of warm activity and having little change with time mainly in the pineal region, which was strongly suspicious of gliomas. Hence this scan was thought to be important in diagnosing this tumour. As an operative procedure, biparieto-occipital craniotomy was successfully performed in the “sea lion” position to remove the tumour totally. Pathological findings indicated a mixture of dispersion and concentration of giant cells possessing prominent nucleoli, abundant chromatin and a prominent nucleus or several nuclei of varying sizes and process-like cell bodies polygonal or irregular in shape. GFAP stain showing no glial fibres and the tumour was thought to be a gangliocytoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01418803
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  • 9
    Electronic Resource
    Electronic Resource
    Identification of P-450"A"L"C in microsomes from alcohol dehydrogenase-deficient deermice: Contribution to ethanol elimination in vivo
    Amsterdam : Elsevier
    Archives of Biochemistry and Biophysics 264 (1988), S. 114-124 
    Details
    ISSN: 0003-9861
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0003-9861(88)90576-0
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  • 10
    Electronic Resource
    Electronic Resource
    Amino acid sequence and relative biological activity of a natriuretic peptide isolated from eel brain
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 170 (1990), S. 883-891 
    Details
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0006-291X(90)92174-X
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