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  • 1
    Electronic Resource
    Electronic Resource
    Angiomyolipoma of the liver: significance of CT and MR dynamic study (1998)
    Springer
    Abdominal imaging 23 (1998), S. 520-526 
    Details
    ISSN: 1432-0509
    Keywords: Key words: Angiomyolipoma—Liver, US, CT, MRI, angiography.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Angiomyolipoma is a benign mesenchymal tumor that has been reported frequently in the kidney but rarely in the liver. In the present study, we present four cases of hepatic angiomyolipoma with different radiologic appearances, discuss differential diagnosis, and review previously reported cases. One of our cases was followed for 8 years. Computed tomography (plain, enhanced, and dynamic study), magnetic resonance imaging (T1-weighted spin echo, T2-weighted spin echo, and dynamic study), ultrasonography, and angiography were performed in all cases. Although different radiologic appearances were observed in the tumors, based on different proportions of fat, blood vessels, and muscle, three cases were diagnosed as angiomyolipoma. In one case, it was quite difficult to make radiologic diagnosis; hepatocellular carcinoma with fatty metamorphosis in part was most likely suspected, but histopathological examination revealed angiomyolipoma with few fat elements. In the present study, early and prolonged enhancement of the lesion with the special pattern of time density/intensity curve was significant for angiomyolipoma, and we suggest that preoperative radiologic diagnosis of the lesion is possible in most of the cases. However, it can be quite difficult to distinguish angiomyolipoma from some hepatocellular carcinomas with fatty metamorphosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002619900391
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  • 2
    Electronic Resource
    Electronic Resource
    Combined effects of NO inhalation and intravenous PGF2α on pulmonary circulation and gas exchange in an ovine ARDS model (1996)
    Springer
    Intensive care medicine 22 (1996), S. 656-663 
    Details
    ISSN: 1432-1238
    Keywords: Key words Adult respiratory distress syndrome ; Nitric oxide ; Sheep ; Lung lavage ; Pulmonary circulation ; Pressure-flow relationship
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objectives: Inhalation of nitric oxide (NO) selectively dilates pulmonary vessels in well-ventilated regions. Prostaglandin F2α (PGF2α) is a vasoconstrictor and is reported to enhance hypoxic pulmonary vasoconstriction. The objective of this study was to examine whether the combination of intravenous PGF2α and inhaled NO in ARDS lungs has a beneficial effect on oxygenation. Design: We investigated the effect of intravenous PGF2α infusion (0.05–10.0 μg/kg per min) with and without NO inhalation (60 ppm) on the hemodynamics and gas exchange in an ovine ARDS model, examining the pulmonary artery pressure versus the flow plot by varying cardiac output. Measurements and results: After lung lavage, NO inhalation reduced the mean pulmonary arterial pressure (MPAP) by decreasing the zero-flow pressure intercept from 10.6±3.8 (mean±SD) to 8.5±3.8 mmHg (p〈0.05) with no significant change in slope. NO inhalation improved PaO2 from 56±12 to 84±38 mmHg (p〈0.005) and reduced pulmonary shunt from 65±5 to 53±8% (Qs/Qt) (p〈0.001). The dose-dependent effects of PGF2α infusion were: (1) increased MPAP attributed to an increased slope in pulmonary artery pressure-flow plot; (2) decreased cardiac index; (3) decreased Qs/Qt with unchanged PaO2. The dose-dependent decrease in Qs/Qt after PGF2α infusion was attributed to the decreased cardiac output. Conclusions: It is suggested that inhalation of NO reduced the critical vascular pressure near alveoli without affecting upstream vessels, while infused PGF2α constricted the larger upstream pulmonary artery vessels without appreciably affecting the critical pressure. Inhalation of NO into well-ventilated lung areas shifted perfusion to well-oxygenated areas, and there was no supplemental shift in blood flow by adding an infusion of PGF2α.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01709742
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  • 3
    Electronic Resource
    Electronic Resource
    Usefulness of central venous oxygen saturation monitoring during cardiopulmonary resuscitation (1994)
    Springer
    Intensive care medicine 20 (1994), S. 450-451 
    Details
    ISSN: 1432-1238
    Keywords: Oxygen saturation ; End-tidal carbon dioxide ; Cardiopulmonary resuscitation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The usefulness of continuous monitoring of central venous oxygen saturation (ScvO2) in comparison with the capnogram during cardiopulmonary resuscitation (CPR) was demonstrated in a cardiac arrest patient. ScvO2 and end-tidal carbon dioxide (ETCO2) decreased following cessation of chest compression or increased during recovery of systemic circulation. During the complete stasis of systemic circulation, when defibrillation was done, ScvO2 did not change, while ETCO2 gradually decreased. However the larger decrease in ScvO2 temporally occurred when chest compression was resumed. And also the ScvO2 monitoring had great advantage to detecting peripheral tissue oxygenation. ScvO2 seems to be no less accurate and reliable monitoring than the capnogram during CPR procedures. Since the capnogram is non-invasively and easily used in cardiac arrest patients, ScvO2 monitoring combined with the capnogram is a more preferable method for assessing the efficacy of ongoing CPR.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01710659
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  • 4
    Electronic Resource
    Electronic Resource
    Combined effects of NO inhalation and intravenous PGF2α on pulmonary circulation and gas exchange in an ovine ARDS model (1996)
    Springer
    Intensive care medicine 22 (1996), S. 656-663 
    Details
    ISSN: 1432-1238
    Keywords: Adult respiratory distress syndrome ; Nitric oxide ; Sheep ; Lung lavage ; Pulmonary circulation ; Pressure-flow relationship
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objectives Inhalation of nitric oxide (NO) selectively dilates pulmonary vessels in well-ventilated regions. Prostaglandin F2α (PGF2α) is a vasoconstrictor and is reported to enhance hypoxic pulmonary vasoconstriction. The objective of this study was to examine whether the combination of intravenous PGF2α and inhaled NO in ARDS lungs has a beneficial effect on oxygenation. Design We investigated the effect of intravenous PGF2α infusion (0.05–10.0 μg/kg per min) with and without NO inhalation (60 ppm) on the hemodynamics and gas exchange in an ovine ARDS model, examining the pulmonary artery pressure versure the flow plot by varying cardiac output. Measurements and results After lung lavage, NO inhalation reduced the mean pulmonary arterial pressure (MPAP) by decreasing the zero-flow pressure intercept from 10.6±3.8 (mean±SD) to 8.5±3.8 mmHg (p〈0.05) with no significant change in slope. NO inhalation improved PaO2 from 56±12 to 84±38 mmHg (p〈0.005) and reduced pulmonary shunt from 65±5 to 53±8% ( $$\dot Qs/\dot Qt$$ ) (p〈0.001). The dose-dependent effects of PGF2α infusion were: (1) increased MPAP attributed to an increased slope in pulmonary artery pressure-flow plot; (2) decreased cardiac index; (3) decreased $$\dot Qs/\dot Qt$$ with unchanged PaO2. The dose-dependent decrease in $$\dot Qs/\dot Qt$$ after PGF2α infusion was attributed to the decreased cardiac output. Conclusions It is suggested that inhalation of NO reduced the critical vascular pressure near alveoli without affecting upstream vessels, while infused PGF2α constricted the larger upstream pulmonary artery vessels without appreciably affecting the critical pressure. Inhalation of NO into well-ventilated lung areas shifted perfusion to well-oxygenated areas, and there was no supplemental shift in blood flow by adding an infusion of PGF2α.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01709742
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    The transition from latent to overt hypoparathyroidism in a child with CATCH 22 who showed subnormal parathyroid hormone response to ethylenediaminetetraacetic acid infusion (1996)
    Springer
    European journal of pediatrics 155 (1996), S. 255-255 
    Details
    ISSN: 1432-1076
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01953951
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  • 6
    Electronic Resource
    Electronic Resource
    Dependence of the cardiovascular effects of pindolol on the individual sympathetic nervous activity (1982)
    Springer
    European journal of clinical pharmacology 22 (1982), S. 383-387 
    Details
    ISSN: 1432-1041
    Keywords: pindolol ; propranolol ; beta-adrenergic activity ; beta-adrenergic sensitivity ; beta-blocking agents ; intrinsic sympathomimetic action
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary To investigate the mechanism of the relative beta-antagonist and agonist properties of pindolol, the cardiovascular effects of i.v. pindolol 0.01 mg/kg were studied in 23 subjects with different baseline levels of cardiac beta-adrenergic function. Baseline cardiac beta-adrenergic activity was assessed by the decrease in heart rate following intravenous propranolol 0.2 mg/kg (ΔHRβ) after parasympathetic blockade with intravenous atropine 0.04 mg/kg. Cardiac beta-adrenergic sensitivity was defined by the positive chronotropic effect of a three minute infusion of isoprenaline 0.005 µg/kg/min. The chronotropic effect of intravenous pindolol was negatively correlated with resting beta-adrenergic activity (R=−0.81, p〈0.001). The traditional point of ΔHRβ, at which pindolol shifted from beta-antagonist to beta-agonist action, was 17 beats/min, i.e. pindolol decreased heart rate in subjects with ΔHRβ greater than 17 bpm, and increased heart rate in those with ΔHRβ less than 17 bpm. The chronotropic effect of intravenous pindolol, however, was positively correlated with beta-sensitivity (R=+0.73, p〈0.001). Thus subjects with the greatest increment in heart rate with isoprenaline had an increased heart rate with pindolol, while those with the lowest increment in heart rate with isoprenaline had a decreased heart rate with pindolol. Intravenous pindolol decreased cardiac index and increased total peripheral resistance in the group with ΔHRβ more than 17 bpm, and it had the contrary actions in the group with ΔHRβ less than 17 bpm. Blood pressure in both groups was not significantly changed by pindolol. Compared to endogenous catecholamines, pindolol was considered to possess higher beta-adrenocepter affinity and weaker beta-adrenoceptor stimulating action. Therefore, pindolol produced a net beta-blocking action in subjects with elevated cardiovascular sympathetic nervous activity and beta-stimulating action in subjects with reduced sympathetic nervous activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542539
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  • 7
    Electronic Resource
    Electronic Resource
    Effects of Oxide on Anodic Behaviours of Graphite Electrodes in Fluoride Molten Salts (1991)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 73-75 (Jan. 1991), p. 401-408 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/20/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.73-75.401.pdf
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  • 8
    Electronic Resource
    Electronic Resource
    Structure of a loop-deleted variant of 3-isopropylmalate dehydrogenase from Thermus thermophilus: an internal reprieve tolerance mechanism (1996)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 52 (1996), S. 124-128 
    Details
    ISSN: 1399-0047
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: A loop-deleted mutant form of 3-isopropylmalate dehydrogenase from Thermus thermophilus was constructed to investigate the relationship between the flexibility of the structure and the thermostability of the enzyme. The structure of the mutant enzyme was determined by X-ray crystallography and was found to be almost the same as that of the native enzyme with a reduced temperature factor. Although the mutant protein had lost the flexible loop, its function and thermostability had remained unchanged. This phenomenon can be explained by an internal reprieve tolerance mechanism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0907444995007190
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  • 9
    Electronic Resource
    Electronic Resource
    Crystallization and preliminary X-ray crystallographic studies of 7α-hydroxysteroid dehydrogenase from Escherichia coli (1996)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 52 (1996), S. 215-217 
    Details
    ISSN: 1399-0047
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: Crystals of 7α-hydroxysteroid dehydrogenase from E. coli, which is a tetramer in its active form, have been obtained by a hanging-drop vapor-diffusion method in the presence of the coenzyme NAD+. Crystals as large as 0.25 × 0.25 × 0.75 mm could be grown within a month at pH 8.5 with polyethylene glycol as precipitating agent. Preliminary X-ray crystallographic analysis revealed that they belong to one of the enantiomorphic space groups P41212 or P43212 with dimensions a = b = 81.66 and c = 214.6 Å, having two subunits in an asymmetric unit. The crystals diffract to at least 2.3 Å resolution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S090744499501002X
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  • 10
    Electronic Resource
    Electronic Resource
    Representation of the fast-rotation function in a polar coordinate system (1977)
    [S.l.] : International Union of Crystallography (IUCr)
    Acta crystallographica 33 (1977), S. 191-193 
    Details
    ISSN: 1600-5724
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: Crowther's fast-rotation function' [Crowther (1972). The Molecular Replacement Method, edited by M. G. Rossmann, pp. 173-183. New York: Gordon & Breach] expression has been modified in a manner in which it is convenient to explore spherical polar coordinates rather than Eulerian angles.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0567739477000382
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