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  • 1
    Electronic Resource
    Electronic Resource
    9β-Lanostane-Type Triterpene Lactones from the Stem Bark of Abies veitchii (1991)
    s.l. : American Chemical Society
    Journal of natural products 54 (1991), S. 1337-1344 
    Details
    ISSN: 1520-6025
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/np50077a017
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Interaction of hydrophobically modified hydroxyethyl cellulose with various added surfactants (1992)
    s.l. : American Chemical Society
    Macromolecules 25 (1992), S. 1304-1310 
    Details
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ma00030a016
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Lack of gastrointestinal glucagon response to hypoglycaemia in depancreatized dogs (1978)
    Springer
    Diabetologia 15 (1978), S. 471-474 
    Details
    ISSN: 1432-0428
    Keywords: Gut glucagon ; depancreatized dogs ; insulin-induced hypoglycaemia ; arginine infusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Fasting (24 h) normal dogs and depancreatized dogs were injected intravenously with highly purified porcine insulin (Actrapid) in the doses of 0.2 U/kg and 0.5 U/kg, respectively. Blood glucose decreased from 152±41 (SEM) mg/100 ml to 39±7 mg/100 ml in the depancreatized dog and from 95±3 mg/100 ml to 42±4 mg/100 ml in the normal animal. Using a specific antiserum for “pancreatic” glucagon, the circulating level of glucagon immunoreactivity did not rise from the basal value of 247±31 pg/ml in the depancreatized group whereas it rose significantly from 223±24 pg/ml to 321±41 pg/ml in the normal group. In contrast intravenous infusion of 7 g of arginine increased “pancreatic” glucagon immunoreactivity in both groups. Thus, extrapancreatic glucagon of the pancreatic type does not respond to hypoglycaemia but to arginine infusion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02342872
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  • 4
    Electronic Resource
    Electronic Resource
    Cyclosporine A-associated fatal central nervous system angiopathy in a bone marrow transplant recipient: an autopsy case (2000)
    Springer
    Acta neuropathologica 99 (2000), S. 680-684 
    Details
    ISSN: 1432-0533
    Keywords: Key words Basilar artery ; Vasoconstriction ; Cyclosporine A ; Bone marrow transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report here the case of a 32-year-old woman who suffered from a unique angiopathy in the central nervous system (CNS). She died of multiple infarcts in the brain stem and cerebellum during treatment with cyclosporine A after bone marrow transplantation for refractory anemia with excess of blasts. The autopsy findings showed segmental narrowing of the basilar artery, in which circumferential dissection of the internal elastic lamina had occurred. The distal portion of the basilar artery was obstructed by upward dislocation of the dissected intima. Similar angiopathy was also observed at multiple sites along the basilar artery branches. These findings suggest endothelial damage, including vasoconstriction and dissection of the CNS arteries.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010051179
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  • 5
    Electronic Resource
    Electronic Resource
    An immunohistochemical study of cytokeratin and glial fibrillary acidic protein in chroid plexus papilloma (1988)
    Springer
    Acta neuropathologica 75 (1988), S. 317-320 
    Details
    ISSN: 1432-0533
    Keywords: Cytokeratin ; Glial fibrillary acidic protein ; Choroid plexus ; Choroid plexus papilloma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cellular localization of cytokeratin and glial fibrillary acidic protein (GFAP) was examined in two normal choroid plexuses and five choroid plexus papillomas by the peroxidase-antiperoxidase (PAP) method and double immunofluorescence (IFL) microscopy. Cytokeratin was observed in the majority of epithelial cells in all samples of normal and neoplastic choroid plexuses. On the other hand, GFAP was observed in some of the constituent epithelial cells in two cases of papilloma. Most of these GFAP-positive papilloma cells were simultaneously positive for cytokeratin, as could be seen by the PAP stainings of serial sections and by the double IFL stainings of the same sections. From these findings, it was suggested that normal and neoplastic choroid plexus epithel cells usually express cytokeratin and that some of the neoplastic cells can simultaneously express boty cytokeratin and GFAP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00690541
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  • 6
    Electronic Resource
    Electronic Resource
    Correlation of DNA ploidy and morphological features of human glioma cell cultures with the establishment of cell lines (1988)
    Springer
    Acta neuropathologica 76 (1988), S. 433-440 
    Details
    ISSN: 1432-0533
    Keywords: Glioma ; Tissue culture ; DNA ploidy ; Morphology ; Established cell lines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Eleven gliomas were serially cultivated and examined for DNA distribution by flow cytometry and simultaneously for morphological features by light microscopy at the various passage levels until passage 50 at most. Seven gliomas (four low-grade gliomas, three anaplastic gliomas) showed a similar DNA distribution pattern with a main diploid and small tetraploid peaks at various passages. In this group, only one culture formed a permanent cell line, whereas six cultures showed a limited growth ranging from 6 to 24 passages. In contrast, the other four gliomas (each an anaplastic glioma) showed a marked change of DNA distribution through passages and finally a single DNA aneuploid population prospered. Each of these four gliomas yielded established cell lines. Thus, it is suggested that the change of DNA ploidy and prosperity of DNA aneuploid populations in flow cytometry might be used as early and reliable indices for the later establishment of glioma-derived permanent cell lines. Since the changes of DNA distribution are frequently associated with the morphological changes, as seen in the latter group, careful tracing of morphological features is valuable in determining of the fate of cultures, especially in the absence of a flow cytometer. The correlation between the potential to become established cell lines and histology of the original gliomas is also discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686381
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  • 7
    Electronic Resource
    Electronic Resource
    Ultrastructural alterations of neuronal cells in a brain stem ganglioglioma (1987)
    Springer
    Acta neuropathologica 74 (1987), S. 307-312 
    Details
    ISSN: 1432-0533
    Keywords: Ganglioglioma ; Neuronal degeneration ; Ultrastructure ; Brain stem ; Brain tumor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A brain stem ganglioglioma in a 9-year-old female was examined ultrastructurally. The constituent neuronal (ganglion) cells displayed various ultrastructural features of neuronal degeneration including Hirano, Lafora and zebra bodies, inclusion-like aggregates of neurofilaments and large dilatations of rough endoplasmic reticulum. Although similar observations have been reported in peripheral neuronal tumors, this is the first reported occurrence in ganglioglioma, an uncommon tumor in the central nervous system. The coincidence of these alterations in the present tumor appeared to be of great interest, however, their exact etiology remained uncertain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688197
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  • 8
    Electronic Resource
    Electronic Resource
    Neuroendocrine markers in central nervous system neuronal tumors (gangliocytoma and ganglioglioma) (1989)
    Springer
    Acta neuropathologica 77 (1989), S. 237-243 
    Details
    ISSN: 1432-0533
    Keywords: Gangliocytoma ; Ganglioglioma ; Ultrastructure ; Immunohistochemistry ; Neuroendocrine markers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We studied five cases of central nervous system neuronal tumor, one gangliocytoma and four gangliogliomas, both ultrastructurally and immuno-histochemically, using antibodies to neuroendocrine markers including tyrosine hydroxylase (TH), serotonin (5HT), somatostatin (SOM), met-enkephalin (MEK), leu-enkephalin (LEK), substance P (SP), gastrin, vasopressin, oxytocin, vasoactive intestinal polypeptide, adrenocorticotropic hormone and calcitonin. In all cases, the presence of dense-core vesicles (60–250 nm) in the neuronal elements was the characteristic ultrastructural finding. Synapses were observed in two cases. Immunohistochemically, variable numbers of neuronal cells showed positive staining for SOM in five cases, TH, MEK and LEK in three cases, and 5HT and SP in one case each. The others were negative. Positive immunoreactivity for multiple markers was shown in all cases. SOM, TH, 5HT and SP were present in the small- to medium-sized cells, while MEK and LEK were almost exclusively confined to the large cells. Our study clearly indicated that these tumors contained neuronal cells which were not homogeneous with regard to neuroendocrine markers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687574
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  • 9
    Electronic Resource
    Electronic Resource
    The vestibulospinal tract: Crossed and uncrossed effects on hindlimb motoneurones in the cat (1975)
    Springer
    Experimental brain research 24 (1975), S. 37-55 
    Details
    ISSN: 1432-1106
    Keywords: Vestibulospinal tract ; Spinal cord ; Motoneurone ; Crossed effects ; EPSP and IPSP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Effects produced by stimulation of Deiters' nucleus on contralateral hindlimb motoneurones were investigated in the cat with intracellular and monosynaptic reflex recording. Polysynaptic PSPs were evoked in all species of motoneurone examined. The minimal synaptic linkage was found to be disynaptic in the excitatory path and trisynaptic in the inhibitory path. Experiments with various lesions to the spinal funiculus and those with mapping of the stimulated sites in the brain stem showed that the effects were evoked almost exclusively via the lateral vestibulospinal tract of the stimulated side. The crossed effects were excitatory in extensor motoneurones of all species studied except for hip extensors (ABSm) in which EPSPs and/or IPSPs were evoked. The effects on flexors, by contrast, were not simple and consisted of EPSPs, IPSPs or a mixture of both. The difference in effects depended, though not entirely, on the species of motor nucleus. Between the excitatory and inhibitory effects on knee flexor (PBSt) motoneurones the former predominated under chloralose and the latter under pentobarbital anaesthesia. By recording PSPs evoked from the two vestibulospinal tracts in the same motoneurone, the convergence pattern and the magnitude of effects from the two tracts were studied. The interneuronal organization of the crossed vestibulo-motoneuronal pathway and its functional significance are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00236016
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  • 10
    Electronic Resource
    Electronic Resource
    Integration in descending motor pathways controlling the forelimb in the cat. 1. Pyramidal effects on motoneurones (1976)
    Springer
    Experimental brain research 26 (1976), S. 509-519 
    Details
    ISSN: 1432-1106
    Keywords: Pyramid ; Forelimb motoneurones ; Disynaptic EPSPs ; Trisynaptic IPSPs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Stimulation of the contralateral pyramid and intracellular recording from forelimb motoneurones was used to investigate corticomotoneuronal pathways in the cat. A train of pyramidal volleys evokes short-latency EPSPs in flexor motoneurones and in many extensor motoneurones. The latency for the on-set after the effective pyramidal volley — usually the third — strongly indicates a disynaptic linkage. These disynaptic EPSPs were common in triceps motoneurones to fast heads but rare in those to slow heads. Pyramidal IPSPs with a slightly longer latency, suggesting a trisynaptic linkage, were found in both flexor and extensor motoneurones. They were common in motoneurones to slow heads of triceps. Disynaptic pyramidal IPSPs were found only occasionally. In addition pyramidal volleys may evoke late large EPSPs and/or IPSPs in any combination with the short-latency PSPs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00238824
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