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  • 1
    Electronic Resource
    Electronic Resource
    Translational mobility of Concanavalin A receptors in normal and neoplastic glial cells (1982)
    Springer
    Acta neuropathologica 58 (1982), S. 215-223 
    Details
    ISSN: 1432-0533
    Keywords: Normal glia ; Neoplastic glia ; Concanavalin A receptors ; Colchicine ; Cytochalasin B
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The dynamics of cell-associated Concanavalin A (Con A) in astrocytes of the newborn rat (RNA), the rat glioma (AC), and the human glioblastoma (GB) were studied in vitro by fluorescence and electron microscopy. Con A receptors on the cell surface were seen usually as a continuous thin layer, and Con A accumulations in fluorescence microscopy were actually Con A receptors on complicatedly infolded cell membrane and collection of Con A pinosomes. No capping occurred in the three types of glial cells. The translational movement of Con A receptors on the cell surface was rapid in the AC, slow in the RNA, and intermediate in the GB, and partly associated with Con A internalization. Con A pinosomes were more numerous in the RNA compared with those in the AC and the GB. Colchicine accelerated the translational mobility of surface Con A receptors more markedly in the AC and the GB than in the RNA. The translational movement Con A receptors, when treated with cytochalasin B, was retarded in the RNA and the GB and rather accelerated in the AC. Con A pinosomes were decreased in the three types of glial cells by treatment with colchicine or cytochalasin B.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00690804
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  • 2
    Electronic Resource
    Electronic Resource
    Lectin histochemistry of human gliomas (1989)
    Springer
    Acta neuropathologica 79 (1989), S. 176-182 
    Details
    ISSN: 1432-0533
    Keywords: Histochemistry ; Lectins ; Gliomas ; Macrophages
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Formalin-fixed and paraffin-embedded specimens of 24 human gliomas were examined histochemically with five lectins: concanavalin A (Con A), wheat germ agglutinin (WGA), Ricinus communis agglutinin 1 (RCA-1), peanut agglutinin (PNA), and Ulex europaeus agglutinin 1 (UEA-1). Although the staining intensity with lectins was variable, tumor cells in five astrocytomas, three oligodendrogliomas, six ependymomas, and one gliosarcoma, were generally positive for Con A, WGA, and RCA-1, and negative for PNA and UEA-1, whereas those in nine glioblastomas were usually positive for Con A and WGA and negative for RCA-1 and PNA as well as UEA-1. The malignancy in neoplastic astrocytes was correlated with the decrease in binding with lectins, especially RCA-1. Blood vessels, particularly the endothelial layers, in all gliomas were stained intensely with all lectins used. Macrophages showed two staining features with lectins; stippled and granular. The former macroplìages were positive for Con A, WGA, RCA-1, and PNA, and negative for UEA-1, whereas the latter macrophages were positive for all lectins used. Thus, the staining characteristics with lectins of macrophages were different from those of any glioma cells and very useful for identification of macrophages in gliomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294376
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  • 3
    Electronic Resource
    Electronic Resource
    Stabilization of c-myc protein in human glioma cells (1993)
    Springer
    Acta neuropathologica 86 (1993), S. 345-352 
    Details
    ISSN: 1432-0533
    Keywords: Glioma ; c-myc transcript ; c-myc protein ; Pulse-chase analysis ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The regulation of c-myc protein, product of c-myc/genes, was studied in four glioma cell lines by Northern blot, pulse-chase dot blot, immunoblot and immunoprecipitation analyses. Northern blot analysis revealed no overexpression of c-myc transcript, and pulse-chase dot blot analysis showed normal turnover rate of c-myc transcript, suggestive of no evidence of aberrant regulation of c-myc at post-transcriptional level. The synthesis levels of c-myc protein were shown by immunoprecipitation and closely associated with the c-myc transcript levels demonstrated by Northern blot, suggestive of no evidence of aberrant translational control of c-myc, whereas they were dissociated from the accumulation levels of c-myc protein shown by immunoblot, suggestive of an evidence of aberrant regulation of c-myc at post-translational level. The mean (±standard deviation) half-lives of c-myc protein in four glioma cell lines were calculated from the pulse-chase immunoprecipitation analysis, and being 98±8 to 143±11 min, were about four-to sixfold longer than normal. In surgical specimens, the immunostain of c-myc protein was not found in normal astrocytes but localized heterogeneously in nuclei of reactive astrocytes and glioma cells, and increased in stained cell number in proportion to malignancy. Although this study was limited to four glioma cell lines, it suggests that the c-myc protein in glioma cells may be accumulated due to its prolonged half-life contributing to an uncontrolled proliferation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00369446
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  • 4
    Electronic Resource
    Electronic Resource
    Immunohistochemical study of fibronectin in human glioma and meningioma (1983)
    Springer
    Acta neuropathologica 59 (1983), S. 119-126 
    Details
    ISSN: 1432-0533
    Keywords: Fibronectin ; Glioma ; Meningioma ; Microscopic angiogenesis grading system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The presence of fibronectin (FN) and glial fibrillary acidic protein (GFAP) in two astrocytomas, 17 glioblastomas, and five meningiomas was studied by indirect immunoproxidase staining of formalin-fixed and paraffin-embedded surgical specimens. Angiogenesis in tumor was scored by the microscopic angiogenesis grading system (MAGS), and plasma FN levels were measured by single radial immunodiffusion. In astrocytomas and glioblastomas, GFAP-positive tumor cells had no FN expression and FN was confined to proliferating vessel walls and the leptomeninges, showing a mutually exclusive FN and GFAP expression. GFAP-positive tumor cells were occasionally surrounded by a network of FN-positive matrix produced by cells derived from the leptomeninges or blood vessels. In meningiomas, FN expression was found in vessel walls and meningioma cells including whorl formations and psammoma bodies. In general, deep immunoperoxidase staining for FN was shown in the endothelial cells and the psammoma bodies. Plasma FN levels were correlated significantly not to the degree of leptomeningeal proliferation but to the MAGS scores in gliomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691597
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  • 5
    Electronic Resource
    Electronic Resource
    Immunohistochemical study of fibronectin in hemangioblastomas and hemangiopericytomas (1984)
    Springer
    Acta neuropathologica 64 (1984), S. 229-233 
    Details
    ISSN: 1432-0533
    Keywords: Fibronectin ; Glial fibrillary acidic protein ; Hemangioblastoma ; Hemangiopericytoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Eight hemangioblastomas and two hemangiopericytomas were studied using indirect immunoperoxidase stains for fibronectin (FN) and glial fibrillary acidic protein (GFAP) in formalin-fixed, paraffinembedded surgical specimens. Stromal cells in hemangioblastomas were GFAP-negative and showed variable FN expression, while GFAP-positive cells were FN-negative, thus suggesting that the stromal cells are not derived from astrocytes. Hemangiopericytoma cells were poorly to intermediately FN-positive. The origin of stromal cells is discussed in the light of their fine structure and the immunohistochemical stains with other cell markers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688113
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  • 6
    Electronic Resource
    Electronic Resource
    Interspecies comparison of c-myc gene in human and rat glioma cell lines (1991)
    Springer
    Acta neuropathologica 81 (1991), S. 382-387 
    Details
    ISSN: 1432-0533
    Keywords: Gliòma ; c-myc ; gene ; c-myc transcript ; c-myc protein ; In situ hybridization ; Immunocytochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Interspecies difference in expression of the c-myc gene between two human and three rat glioma cell lines was studied with use of a human c-myc probe. The c-myc deoxyribonucleic acid (DNA) fragments detected at higher stringency in Southern blotting, showed a difference in size and gene copy number between human and rat glioma cells. The c-myc transcript was detected at both higher and lower stringencies in Northern blotting in human glioma cells, whereas it was demonstrated only at lower stringency in rat glioma cells, and the c-myc transcript was seen in cytoplasms of both glioma cells by in situ hybridization. The c-myc protein, if examined with anti-human c-myc protein monoclonal antibody, was observed as two separated components in Western blotting and localized immunocytochemically in nuclei in human glioma cells, whereas it was detected as three separate forms in Western blotting and shown in both nuclei and cytoplasm in rat glioma cells. The above discrepancy in manifestation of c-myc DNA fragments, transcript and protein could be due to the difference in nucleotide sequence of c-myc gene between human and rat glioma cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00293458
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  • 7
    Electronic Resource
    Electronic Resource
    Immunohistochemistry of leukotriene C4 in experimental cerebral vasospasm (1991)
    Springer
    Acta neuropathologica 81 (1991), S. 401-407 
    Details
    ISSN: 1432-0533
    Keywords: Leukotriene C4 ; Basilar artery ; Neutrophils ; Macrophages ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Experimental cerebral vasospasm was produced in a “two-hemorrhage” canine model and examined by immunohistochemistry for leukotriene C4 (LTC4). The immunostain for LTC4 showed a strong positivity in intima and adventitia and a scattered reaction in media of normal basilar artery. The immunoreactivity after subarachnoid hemorrhage (SAH) was little changed in intima and media. Inflammatory cells which were characterized histochemically as neutrophils and macrophages, were shown to infiltrate from the adventitia of basilar artery to the periphery of blood clot after SAH and were markedly immunoreactive for LTC4. Also the neutrophils increased in number with the lapse of time after SAH. Thus, it would be reasonable to conclude that the LTC4 responsible for the development of vasospasm would most likely be produced from the infiltrating neutrophils and macrophages. In addition, neurons in hypothalamus, median eminence, and pons, as well as ependymal and arachnoid cells were immunoreactive for LTC4 both in the control and after SAH, whereas astrocytes and oligodendrocytes were not immunoreactive for LTC4 in either case.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00293461
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  • 8
    Electronic Resource
    Electronic Resource
    The Modern Girl around the World: A Research Agenda and Preliminary Findings (2005)
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
    Gender & history 17 (2005), S. 0 
    Details
    ISSN: 1468-0424
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: History
    Notes: Our research collaboration examines how the Modern Girl emerged as a global phenomenon in the first half of the twentieth century. By wearing provocative fashions and pursuing romantic love, Modern Girls everywhere appeared to disregard the roles of dutiful daughter, wife and mother. We develop the Modern Girl as a heuristic category that allows new insights into forces of globalisation and manifestations of gendered modernity. Through a case study of cosmetics advertising in China, India, South Africa, Germany and the United States, we show that the Modern Girl in each locale was shaped through multidirectional citations of elements from elsewhere, through transnational processes of racialisation and through distinct articulations of nationalism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0953-5233.2006.00382.x
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  • 9
    Electronic Resource
    Electronic Resource
    Expressions of Matrilysin and Stromelysin in Human Glioma Cells
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 192 (1993), S. 999-1003 
    Details
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1006/bbrc.1993.1515
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  • 10
    Electronic Resource
    Electronic Resource
    Clinical Utility of Fine-Needle Aspiration Cytology of the Thyroid (1988)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Medicine 39 (1988), S. 255-260 
    Details
    ISSN: 0066-4219
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.me.39.020188.001351
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