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  • 1
    Electronic Resource
    Electronic Resource
    Diagnosis of hepatic cavernous hemangioma by fine needle aspiration biopsy under ultrasonic guidance (1990)
    Springer
    Abdominal imaging 15 (1990), S. 39-42 
    Details
    ISSN: 1432-0509
    Keywords: Hepatic hemangioma ; Fine needle aspiration biopsy ; Ultrasonic guidance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Percutaneous aspiration biopsy of the liver using a heparinized 22-gauge needle was performed under ultrasonic guidance in 11 patients with hepatic cavernous hemangioma. Ten (91%) of 11 biopsy specimens obtained were cytologically diagnostic for hemangioma. No indications of malignancy were found. There was no relation between the cytological diagnosis and the location, size, or ultrasonographic findings. No complications were encountered. These findings indicate that cytological examination of the liver by fine needle aspiration biopsy is useful in diagnosing hepatic cavernous hemangioma of any size and in any location, provided optimal route to the lesions is chosen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01888731
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  • 2
    Electronic Resource
    Electronic Resource
    Hookwire localizer as an aid for ultrasonic detection of small liver nodules (1993)
    Springer
    Abdominal imaging 18 (1993), S. 47-49 
    Details
    ISSN: 1432-0509
    Keywords: Localizer ; Liver, small nodules ; Liver, hepatocellular carcinoma ; Ultrasonography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We applied a V-shaped localizer and evaluated its clinical usefulness in nine patients with small hepatic nodules less than 2 cm in diameter. A small hepatic nodule was punctured with a 21-gauge localization needle under ultrasonic guidance, and the V-shaped localizer was pushed into the nodule with a wire. The localizer could be observed as a strong echo line by ultrasonography and as a highdensity bar by computed tomography (CT). By this method, it was possible to precisely localize the nodule. Intraoperative ultrasonography became less time-consuming, and resection of the nodules could be confirmed with low-kilovoltage radiography.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00201701
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  • 3
    Electronic Resource
    Electronic Resource
    Polaprezinc Attenuates Helicobacter pylori-Associated Gastritis in Mongolian Gerbils (2002)
    Oxford, UK : Blackwell Science Ltd
    Helicobacter 7 (2002), S. 0 
    Details
    ISSN: 1523-5378
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background. The ammonia-monochloramine system plays an important role in Helicobacter pylori-associated gastric mucosal injury. Polaprezinc, a new antiulcer agent, has a scavenging action against monochloramine. The aim of the experiment was to investigate the inhibitory effects of polaprezinc on the H. pylori-induced gastritis in Mongolian gerbils.Materials and Methods. Mongolian gerbils fasting for 24 hours were orally given culture broth containing 2–4 × 108 colony-forming units of H. pylori ATCC 43054 per milliliter. From 4 hours after inoculation until the end of the experiment, gerbils were given chow pellets with or without 0.02% polaprezinc. All gerbils were killed 12 weeks later. The grades of H. pylori density and histologic features of gastritis were evaluated in accordance with the Updated Sydney System. The scavenging effect of polaprezinc on monochloramine was investigated spectrophotometrically.Results. Polaprezinc had little or no influence on the H. pylori density in both pyloric and fundic mucosae. However, it significantly attenuated the development of polymorphonuclear neutrophil activity, mononuclear infiltration, and surface epithelial erosion in both pyloric and fundic mucosae compared with those of the control group. H. pylori inoculation significantly increased the heights of both pyloric and fundic mucosae (mainly due to the increased height of foveolar hyperplasia), but polaprezinc inhibited the increase of mucosal thickness in both pyloric and fundic mucasae. No intestinal metaplasia was detected in this study. Spectrophotometric examination revealed that polaprezinc scavenged monochloramine.Conclusions. Polaprezinc inhibited the development of H. pylori-induced gastritis through its scavenging action against monochloramine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1523-5378.2002.00114.x
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  • 4
    Electronic Resource
    Electronic Resource
    Inhibition by ginsenoside Rg3 of bombesin-enhanced peritoneal metastasis of intestinal adenocarcinomas induced by azoxymethane in Wistar rats (1997)
    Springer
    Clinical & experimental metastasis 15 (1997), S. 603-611 
    Details
    ISSN: 1573-7276
    Keywords: azoxymethane ; bombesin ; cancer metastasis ; ginsenoside Rg3 ; intestinal cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of concomitant use of bombesin and ginsenoside Rg3 on the incidence of peritoneal metastasis of intestinal adenocarcinomas induced by azoxymethane were investigated in male inbred Wistar rats. From the start of the experiment, rats were given weekly s.c. injections of azoxymethane (7.4mg/kg body weight) for 10 weeks and s.c. injection of bombesin (40μg/kg body weight) every other day, and from week 20, s.c. injections of ginsenoside Rg3 (2.5 or 5.0mg/kg body weight) every other day until the end of the experiment in week 45. Bombesin significantly increased the incidence of intestinal tumors and cancer metastasis to the peritoneum in week 45. It also significantly increased the labeling index of intestinal cancers. Although administration of a higher dose of ginsenoside Rg3 with bombesin had little or no effect on the enhancement of intestinal carcinogenesis by bombesin, the location, histologic type, depth of involvement, infiltrating growth pattern, labeling and apoptotic indices and tumor vascularity of intestinal cancers, it significantly decreased the incidence of cancer metastasis. These findings indicate that ginsenoside Rg3 inhibits cancer metastasis through activities that do not affect the growth or vascularity of intestinal cancers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018491314066
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  • 5
    Electronic Resource
    Electronic Resource
    Suppression by apigenin of peritoneal metastasis of intestinal adenocarcinomas induced by azoxymethane in Wistar rats (2000)
    Springer
    Clinical & experimental metastasis 18 (2000), S. 657-662 
    Details
    ISSN: 1573-7276
    Keywords: apigenin ; azoxymethane ; bombesin ; cancer metastasis ; intestinal cancer ; MMP-9 ; MAPK
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of a naturally occurring flavonoid apigenin on the development of bombesin-enhanced peritoneal metastasis from intestinal adenocarcinomas induced by azoxymethane was investigated in male Wistar rats. From the start of the experiment, rats were given weekly s.c. injections of azoxymethane (7.4 mg/kg body weight) for 10 weeks and s.c. injection of bombesin (40 μg/kg body weight) every other day, and from week 16, s.c. injections of apigenin (0.75 or 1.5 mg/kg body weight) every other day until the end of the experiment in week 45. Bombesin significantly increased the incidence of intestinal tumors and cancer metastasis to the peritoneum in week 45. It also significantly increased the labeling index of intestinal cancers. Although administration of apigenin at either dose with bombesin had little or no effect on the enhancement of intestinal carcinogenesis by bombesin, the location, histologic type, depth of involvement, infiltrating growth patterns and labeling index, it was found to decrease significantly the incidence of cancer metastasis. Apigenin significantly decreased the incidence of lymphatic vessel invasion of adenocarcinomas, which was enhanced by bombesin. In vitro experiments revealed that apigenin inhibited bombesin-enhanced phosphorylation of mitogen-activated protein kinase (MAPK), but not matrix metalloprotease (MMP)-9 expression. Our findings indicate that apigenin inhibits cancer metastasis through inhibition of phosphorylation of MAPK.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1013133803806
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  • 6
    Electronic Resource
    Electronic Resource
    More effective endoscopic resection with a two-channel colonoscope for carcinoid tumors of the rectum (1996)
    Springer
    Diseases of the colon & rectum 39 (1996), S. 1438-1439 
    Details
    ISSN: 1530-0358
    Keywords: Carcinoid tumor ; Rectum ; Two-channel colonoscope ; Colonoscopic resection ; Surgical technique
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract PURPOSE: Complete resection of small carcinoid tumors of the rectum is difficult with conventional polypectomy, because these tumors are most often located in the submucosal layer of the rectal wall. To completely remove these tumors, we used a two-channel videocolonoscope with which both a grasping forceps and a polypectomy snare could be used simultaneously. We evaluated its clinical usefulness in comparison with one-channel colonoscopic polypectomy. METHODS: At Osaka Medical Center for Cancer and Cardiovascular Diseases, seven carcinoid tumors in seven patients were removed with a one-channel videocolonoscope from 1985 to 1992. In 1993 and 1994, ten tumors in nine patients were removed with a two-channel colonoscope. RESULTS: The rate of complete removal of carcinoid tumors with a two-channel videocolonoscope (9 of 10 tumors, 90 percent) was significantly higher (P〈0.05) than with a one-channel videocolonoscope (2 of 7 tumors, 29 percent). No complications occurred during or after endoscopic resection with a two-channel colonoscope. CONCLUSIONS: Endoscopic resection with a two-channel colonoscope is a useful and safe method for resection of small carcinoid tumors of the rectum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02054536
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  • 7
    Electronic Resource
    Electronic Resource
    Usefulness of Simple Endoscopic Aspiration Cytology of Pancreatic Juice for Diagnosis of Early Pancreatic Neoplasm (A Prospective Study) (1997)
    Springer
    Digestive diseases and sciences 42 (1997), S. 1796-1803 
    Details
    ISSN: 1573-2568
    Keywords: PANCREATIC NEOPLASM ; PURE PANCREATIC JUICE ; CYTOLOGY ; ENDOSCOPIC RETROGRADE PANCREATOGRAM ; EARLY DIAGNOSIS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract For detection of early cancer of the pancreas,endoscopic aspiration cytology of pancreatic juicewithout endoscopic retrograde pancreatography wasperformed in 64 consecutive outpatients who had symptoms or findings that suggested pancreatic disease.Patients with positive or suspicious cytologic resultsor abnormal US findings were admitted and underwentdetailed examinations. Positive and suspicious cytologic results were obtained in 2 and 10 patients,respectively. Of those with positive and suspiciouscytologic results, two, and one patient, respectively,were ultimately found to have pancreatic neoplasms. Of these three resected specimens, one was insitu carcinoma and two presented marked atypia. Allpatients were alive with no evidence of recurrence. Nofurther cases of pancreatic neoplasm were found. Complications from the procedure did notdevelop in any patient. This technique is useful in thediagnosis of early neoplasms of the pancreas, because itis simple and safe to perform for outpatients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018842305690
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  • 8
    Electronic Resource
    Electronic Resource
    Endoscopic ultrasonography in diagnosis and staging of pancreatic cancer (1995)
    Springer
    Digestive diseases and sciences 40 (1995), S. 696-700 
    Details
    ISSN: 1573-2568
    Keywords: endoscopic ultrasonography ; pancreatic cancer ; early diagnosis ; locoregional spread assessment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The accuracy of endoscopic ultrasonography (EUS) for diagnosis of pancreatic cancers was evaluated in consecutive 232 patients with possible pancreatic cancer, and that for assessment of their locoregional spread was evaluated in 28 patients with pancreatic cancer subjected to pancreatectomy, in comparison with the accuracies of transabdominal ultrasonography (US) and computed tomography (CT). EUS was found to be significantly more accurate than US or CT and was especially useful for detecting small pancreatic cancers of less than 2 cm in diameter. With EUS, pancreatic cancers could be detected as a hypoechoic mass with a relatively unclear margin and irregular internal echoes. EUS was also more sensitive than CT and US for detecting venous and gastric invasions: it was more useful for detecting direct invasion of pancreatic cancers when the tumors were less than 3 cm in diameter. These findings indicate that EUS is an accurate method for diagnosis of pancreatic cancer and assessment of their locoregional spread and is particularly useful for detecting small tumors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02064392
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  • 9
    Electronic Resource
    Electronic Resource
    Clinicopathological features and endoscopic diagnosis of superficial early adenocarcinomas of the large intestine (1993)
    Springer
    Digestive diseases and sciences 38 (1993), S. 1333-1337 
    Details
    ISSN: 1573-2568
    Keywords: superficial early colorectal cancer ; chromoendoscopy ; de novo cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract From October 1987 to March 1991, 21 (8%) superficial early cancers were found among 256 early colorectal cancers (Dukes A and B1). Superficial early cancers were defined as early cancers less than 3 mm in height. These tumors were found scattered throughout the large intestine and were often observed as reddish spots, which were easily overlooked without careful observation. Histologically, 19 (90%) of them were well-differentiated adenocarcinomas, and five (24%) of them reached the submucosal layer. Eighteen (86%) of them were not associated with adenoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01296086
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  • 10
    Electronic Resource
    Electronic Resource
    Low Prevalence of Helicobacter pylori Infection in Patients with Hamartomatous Fundic Polyps (1998)
    Springer
    Digestive diseases and sciences 43 (1998), S. 766-772 
    Details
    ISSN: 1573-2568
    Keywords: HELICOBACTER PYLORI ; HAMARTOMATOUS FUNDIC POLYP ; ADHERENCE ; IgA ; LEWIS B ANTIGEN
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Helicobacter pylori infection of the gastricmucosal surface was investigated in patients withhamartomatous fundic polyps or hyperplastic polyps andin patients without endoscopic evidence of disease(healthy subjects). Presence of H. pylori infection wasdetermined by culture, histologic examination, and theendoscopic phenol red test. Adherence of H. pylori wasevaluated with scanning electron microscopic examination of antral biopsy specimens. Bothprevalence of H. pylori infection (P 〈 0.001) and H.pylori adherence (P 〈 0.05) were less in patientswith hamartomatous fundic polyps than in healthy subjects and patients with hyperplastic polyps.However, the percentages of plasma cells in gastricmucosa that contained IgA and of gastric epithelialcells that expressed Lewis b did not differsignificantly among the three groups. These findings suggestthat defense mechanisms against the attachment of H.pylori other than IgA or Lewis b antigen are present inpatients with hamartomarous fundic polyps.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018814014139
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