ISSN:
1432-1211
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract The influence of the major histocompatibility (B) complex on acquired immunity to the avian coccidium Eimeria tenella was studied in 217 F4 segregants (B 2 B 2, B 2 B 5, B 5 B 5) of a cross between inbred lines 61 (B 2 B 2) and 151 (B 5 B 5) and segregating haplotype combinations of UNH105 (B 23 B 23 B 23 B 24, B 24 B 24), a noninbred line of New Hampshire chickens. Chickens were immunized at 6 weeks of age with 500 oocysts daily for 5 days, then challenged 14 days later with 10000 oocysts. Responses to infection were evaluated by cecal lesion scores, body weight gain, delayed wattle reaction (DWR), and spleen weight. The F4 segregants of genotypes B 2 B 5 and B 5 B 5 exhibited greater immunity to challenge than B 2 B 2 chickens. B 5 B 5 chickens showed a significantly greater DWR following immunization and larger spleens 6 days after the challenge than either of the other genotypes. However, both BIBS and B 5 B 5 chickens demonstrated significantly lower lesion scores than B 2 B 2 chickens. There were no significant differences in weight gain among these genotypes. Among 139 line UNH105 segregants, B 23 B 23 hosts had significantly lower lesion scores than B 24 B 24 chickens. No other differences in immune response among line UNH105 genotypes were detected.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00430307
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