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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 51 (1929), S. 1754-1755 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Bioenergetics 226 (1971), S. 433-452 
    ISSN: 0005-2728
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Bioenergetics 205 (1970), S. 121-123 
    ISSN: 0005-2728
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    BBA - Protein Structure 295 (1973), S. 188-207 
    ISSN: 0005-2795
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Industrial & engineering chemistry 44 (1952), S. 857-861 
    ISSN: 1520-5045
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Industrial and engineering chemistry 2 (1930), S. 377-380 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Journal of neuroendocrinology 17 (2005), S. 0 
    ISSN: 1365-2826
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: It is becoming increasingly evident that GABA plays an important role in the regulation of gonadotrophin-releasing hormone (GnRH)-1 neurones via the GABAA receptor. The aim of the present study was to characterise expression of the GABAA receptor within the GnRH-1 system across development. The expression pattern of five GABAAα subunits and one GABAAβ subunit was first examined within individual GnRH-1 neurones by the polymerase chain reaction. A significant increase in the expression of GABAAα2 and a significant decrease in the expression of GABAAα6 over time were found. Of the other subunits examined, two (α1 and α3) showed no differences in expression and two (α4 and β3) showed variable low incidence of expression. Given the reciprocal relationship of α2 and α6 expression, we hypothesised that there is a developmental switch in the expression of these subunits in GnRH-1 neurones. To investigate this hypothesis, single- and double-label immunocytochemistry for GABAAα2 and α6 and GnRH-1 was performed in tissue from ages E12.5 to adulthood, as well as in nasal explants. We show that GABAAα2 and α6 are present in the GnRH-1 neuronal system both in vivo and in vitro and that the levels of expression are altered as a function of age.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Journal of nondestructive evaluation 9 (1990), S. 155-165 
    ISSN: 1573-4862
    Keywords: Ultrasonic inspection ; inhomogeneous anisotropic media ; austenite ; raytracing ; finite differences
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract The strength of austenitic welds will be considerably reduced if cracks are present. To guard against this possibility good workmanship is essential; quality is monitored by inspecting the welds after manufacture. Ultrasound is the favored method of inspection but there are difficulties associated with this in the coarse-grained columnar weld structures often associated with austenitic materials. We present two different approaches to modeling such inspections: ray tracing and full numerical solution of the governing wave equation. We show that the two approaches, although very different in physical nature and numerical method, give similar and consistent results.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Bradford : Emerald
    British journal of clinical governance 7 (2002), S. 27-33 
    ISSN: 1466-4100
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Medicine
    Notes: Standing Medical Advisory Committee (SMAC) guidance for prevention of coronary heart disease (CHD) and the National Service Framework - Coronary Heart Disease both require the identification of patients at high risk of CHD for targeted treatment with statins. Since the best method of identifying these patients is unknown, we compared population screening with opportunistic case finding in a discrete event computer simulation model of the population aged 45-64 in one local health group in Wales. The main outcome measures were numbers of CHD and all-cause deaths and extra patient-years of drug treatment. Screening and case finding were of similar effectiveness in identifying high risk individuals to prevent CHD and all-cause mortality during the five years simulated. The extra patient-years of drug treatment required by a population screening programme suggests that screening would not be cost effective. Concludes that opportunistic case finding is the method of choice in primary care.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Archive for rational mechanics and analysis 112 (1990), S. 63-81 
    ISSN: 1432-0673
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Physics
    Notes: Abstract It is well-known that rarefaction shocks are unstable solutions of nonlinear hyperbolic conservation laws. Indeed, for scalar equations rarefaction shocks are unstable in the class of smooth solutions, but for systems one can only say in general that rarefaction shocks are unstable in the larger class of weak solutions. (Here unstable refers to a lack of continuous dependence upon perturbations of the initial data.) Since stability in the class of weak solutions is not well understood, ([T, TE]), “entropy” considerations have played a leading role in ruling out shocks that violate the laws of physics. However, for non-strictly hyperbolic systems the analogy with the equations of gas dynamics breaks down, and general entropy or admissibility criteria for the variety of shocks which appear, (see, e.g., [IMPT]), are not known. In this paper we address the question of when the instability of a shock can be demonstrated within the class of smooth solutions alone. We show by elementary constructions that this occurs whenever there exists an alternative solution to the Riemann problem with the same shock data which consists entirely of rarefaction waves and contact discontinuities with at least one non-zero rarefaction wave. We show that for 2×2 strictly hyperbolic, genuinely nonlinear systems the condition is both necessary and sufficient. We show too that for the full 3×3 (Euler) equations of gas dynamics with polytropic equations of state, rarefaction shocks of “moderate” strength are unstable in the class of smooth solutions if and only if the adiabatic gas constant γ satisfies 1 〈 γ 〈 5/3 (see Theorem 8). More precisely, there is a constant y *, 0 〈 y * 〈 1, depending only on γ, such that if y * p l≦p r≦p l for 1-shocks, and if y * p r≦P l≦p r for 3-shocks (where p r and p l denote the pressures on both sides of the rarefaction shock), then the shock is unstable if and only if 1 〈 γ 〈 5/3. Thus for such shocks, the theory of the Riemann problem for polytropic gases in the range 1 〈 γ 〈 5/3 can be rigorously developed with a knowledge of the smooth solutions alone by using stability under smoothing as an admissibility criterion, rather than by using the classical entropy inequalities.
    Type of Medium: Electronic Resource
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