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  • 1
    ISSN: 0942-0940
    Keywords: Infant ; brain tumours ; irradiation ; sequelae
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Between 1975 and 1989, 98 children with brain tumours under the age of three at time of diagnosis were entered into a retrospective study. Twenty of them are alive and free of tumour more than five years after treatment and were evaluated in this study. Thirteen tumour localizations were infratentorial and 7 were supratentorial. A histological examination was performed in 15 patients: 5 ependymomas, 6 medulloblastomas and 4 astrocytomas were identified. Fifteen patients underwent surgical removal of tumour, all but one received radiotherapy and 8 were given chemotherapy. Only two children have not late effects. Analysis of long-term sequelae in survivors showed central endocrinopathies in 14 (70%), a neurological handicap in 13 (65%) and impaired cognitive functions in 17 (85%). Irradiation was clearly responsible for mental sequelae in 7 patients and endocrinopathies in 6 patients. The other possible causes are tumour injury, hydrocephalus or surgery. The risks incurred with radiotherapy and advances in infant brain tumour therapy are discussed.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Cancer Genetics and Cytogenetics 63 (1992), S. 147 
    ISSN: 0165-4608
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1573-7217
    Keywords: primary sarcomas ; breast sarcoma ; cystosarcoma phyllodes ; immunohistochemistry ; histograde ; prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The clinical and pathological features of 33 previously untreated patients with primary breast sarcoma were retrospectively analysed to evaluate the prognostic significance of histologic variables on survival. The series comprised 17 cystosarcomas phyllodes and 16 stromal sarcomas (excluding angiosarcomas). All tumors were reviewed and classified in similar fashion to extramammary soft tissue sarcomas. In addition, immunohistochemical studies were performed on paraffin sections with a panel of several antibodies directed against cytoskeletal filaments and cellular enzymes; five cases were also examined by electron microscopy. Most tumors were malignant fibrous histiocytoma (21 cases) and fibrosarcoma (6 cases) types. Surgery was the main therapy. Metastasis-free survival rate was significantly correlated only with histological grade, consisting of tumor differentiation, tumor necrosis, and mitotic activity. Courses and survivals of the cystosarcoma and stromal groups were identical, questioning the clinical value of this pathologic distinction. All local recurrence, metastasis, or death occurred within 30 months, though follow-up was much longer. Immunohistochemistry was disappointing for identification of specific histologic sub-types.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-2161
    Keywords: Bone neoplasms ; Neuroepithelioma ; Primary neuro-ectodermal tumors ; Ewing sarcoma ; Round cell tumor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Radiographs and clinical charts were reviewed in a series of 13 cases of primary neuroectodermal bone tumors, involving 9 males and 4 females, aged from 3 to 32 years (average: 15 years). The average delay between the onset and diagnosis was 5 months. Fever and other systemic symptoms were present in 6 cases; in 4 cases a fracture was the mode of presentation. Seven patients had metastases (4 involving bone) at the time of presentation. Only one patient is still alive after 5 years. In the 10 patients who died as a direct result of the tumor, death occured on average 8 months following diagnosis if metastases were present initially, and 36 months after the diagnosis otherwise. Tumors predominantly involved the leg (7 cases), the pelvis (2 cases), and the humerus (2 cases), the involvement being both diaphyseal and metaphyseal. The radiologic appearance is that of an aggressive, poorly demarcated tumor, with cortical destruction, periosteal reaction and soft tissue invasion. Comparison with Ewing sarcoma shows little radiologic or clinical difference, except for a poorer prognosis in neuroectodermal bone tumors. Both bone tumors may have a similar neuroectodermal origin, with Ewing sarcoma representing the undifferentiated variety.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1573-7217
    Keywords: apocrine carcinomas ; infiltrating breast cancer ; prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have reviewed the morpho-functional criteria for infiltrating apocrine carcinomas of the breast and analysed long term follow-up of this entity. Thirty-four cases of pure apocrine carcinomas were retrieved from the files of the Dept. of Pathology, IGR, France, for the years 1955–1982. Each case was matched with two controls of other infiltrating ductal carcinomas according to the most important prognostic parameters: nodal status, histograde, anatomic tumor size, and patient age. No significant difference between the survival curves of the two groups was seen. Apocrine carcinoma, although possessing peculiar morphological, ultrastructural, biochemical, and immunohistochemical features to merit recognition as a separate histologic variant of breast cancer, by itself has no apparent clinical significance.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1569-8041
    Keywords: ABMT ; anaplastic large-cell lymphoma ; children ; relapse ; vinblastine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose:to study response to chemotherapy and the outcome ofchildren treated for a relapsed anaplastic large-cell lymphoma (ALCL) and toevaluate the role of bone marrow transplantation (BMT) in these patients. Patients and methods:Clinical data concerning the 41 relapsesthat occurred in 119 patients with ALCL enrolled in 3 consecutive studiessince 1975 were analysed. First-line treatment consisted of intensivechemotherapy according to the COPAD protocol for the first series of 12patients treated between 1975 and 1989 and to the SFOP (French Society ofPediatric Oncology) HM protocols for the 30 patients treated between 1989 and1997. Twenty-eight patients were treated with CV(B)A (CCNU, vinblastine, ara-Cwith or without bleomycin), and the others with miscellaneous protocols forrecurrent disease. Fifteen patients underwent autologous BMT and 1 allogeneicBMT while in CR2. Results:Thirty-six of forty-one (88%) patients achievedCR2. With a median follow-up of 5 years, 12 patients died, 9 of their diseaseand 29 patients are alive in CR2 (20 patients), CR3 (5 patients), CR4 (2patients), CR5 (1 patient) or CR6 (1 patient). Overall and disease-freesurvival are respectively 69% (53%–82%) and44% (29%–61%) at three years. In univariateanalysis, patients treated with ABMT while in CR2 did not appear to have abetter outcome than the other. Remarkably, a long-lasting remission wasobtained in 8 of 13 patients treated with weekly vinblastine for a relapseincluding 6 relapses occurring after ABMT. Conclusions:Relapsed ALCL are highly chemosensitive but over40% of the patients experience several relapses. Prolonged conventionalchemotherapy based on vinblastine might, in some cases, be as efficient asshort intensive treatment with ABMT.
    Type of Medium: Electronic Resource
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