ISSN:
1435-1463
Keywords:
Apomorphine
;
growth hormone
;
prolactin
;
flupenthixol isomers
;
dopamine receptor
;
stereospecificity
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The stereospecificity of the D-2 receptor mediating the growth hormone (GH) response to apomorphine (Apo) and the D-2 receptor regulating prolactin (PRL) secretion were investigated in 10 normal men by examining the effects of cis-flupenthixol (cis-Fx) and trans-flupenthixol (trans-Fx). cis-Fx (1 mg six hourly times four doses) antagonized the GH response to Apo HCl (0.5 mg sc) and increased basal serum PRL concentrations whereas the transisomer showed no effect. These findings (a) provide further evidence that the GH response to Apo is mediated by stimulating dopamine (DA) receptors, and, (b) demonstrate stereospecificity of the DA receptor mediating the GH response to Apo and the DA receptor regulating PRL secretion.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01244707
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