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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 115 (1993), S. 12629-12630 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Analytical chemistry 64 (1992), S. 672-677 
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of organic chemistry 29 (1964), S. 2834-2838 
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of organic chemistry 29 (1964), S. 2839-2844 
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 83 (1961), S. 851-855 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Development genes and evolution 165 (1970), S. 217-225 
    ISSN: 1432-041X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Zusammenfassung 1. Nach Behandlung männlicher verpuppungsreifer Vorderbeinscheiben vonDrosophila melanogaster mit Colchicin (Konz. 0,005–1 mg/ml) und anschließender Implantation in gleichaltrige Larvalwirte manifestiert sich ein segmentspezifisches Schädigungsmuster, wobei die Differenzierung des Trochanters am stärksten gehemmt wird. Innerhalb der Tarsalstrukturen sind die Klauen sensibler als die Geschlechtskammzähne. 2. Wird den Colchicin-behandelten Scheiben durch Implantation in jüngere Larven oder in Adultwirte vor der Metamorphose Zeit zur Proliferation zur Verfügung gestellt, so zeigen sie Restitutionsleistungen. 3. Die 8tägige Kultur der mit wirksamen Colchicinkonzentrationen behandelten Scheiben in den adulten Wirten führt in vielen Fällen zu Transdeterminationen. Typus und relative Häufigkeit des Auftretens der allotypischen Elemente sind nach Colchicinbehandlung gleich wie nach mechanischer Desintegration der Beinscheiben. 4. Weder sockellose Borsten noch andere Borstenmodifikationen konnten durch Colchicinbehandlung ausgelöst werden.
    Notes: Summary 1. Treatment of male foreleg disks of late 3rd instar larvae ofDrosophila melanogaster with Colchicinein vitro (Conc. 0.005–1 mg/ml) and implantation into larval hosts of the same age results in the formation of a characteristic pattern of damage, whereby the trochanter is most severely reduced. Claws are much more sensitive to the same concentration of the drug than the sex comb teeth. 2. When Colchicine-treated disks are implanted into young larval or adult hosts, the disks proliferate and structures of all leg segments can be formed. The frequency of the different leg structures formed depends on the concentration of Colchicine used and on the length of the culture period. 3. After culturing the Colchicine-treated disks for 8 days in adult hosts, transdeterminations occur in many disks. The pattern and relative frequencies of allotypic structures formed are identical after Colchicine treatment and mechanical disintegration of the disks. 4. Bristles without sockets or any other modification of the bristle organ were never observed, even after treatment of the disk with high concentrations of Colchicine.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-041X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Zusammenfassung 1. Diein vitro-Behandlung mÄnnlicher Vorderbeinscheiben vonDrosophila melanogaster mit Mitomycin C (Konz. 0,002–1 mg/ml) und anschlie\ende Implantation in larvale Wirte bewirkt die Differenzierung von sockellosen Borstenorganen. Das reziproke PhÄnomen, das Auftreten borstenloser Sockel, konnte dagegen nie beobachtet werden. Neben dieser spezifischen Wirkung auf die Borstendifferenzierung ist auch die allgemeine Differenzierungsleistung der Beinscheibe stark herabgesetzt. 2. Auch die Anzahl der „bracts“ wird durch die Behandlung mit Mitomycin reduziert, wÄhrend die Bildung von Haaren und Klauen nur bei hohen verwendeten Konzentrationen unterbleibt. Wir vermuten, da\ die Differenzierung der „bracts“ von der Bildung ganzer Borstenorgane oder von Sockeln abhÄngt. 3. In verschiedenen Versuchsserien variierten wir das Alter der verwendeten Scheiben zur Zeit der Behandlung von 72 Std nach Eiablage bis 8 Std nach Pupariumbildung. Dabei stellten wir fest, da\ mit zunehmendem Alter der behandelten Scheiben auch die Anzahl der gebildeten sockellosen Borstenorgane zunimmt. 4. Weder in der Wirkung auf die gesamte Differenzierungsleistung noch auf die Differenzierung der Sockel lie\ sich ein statistisch gesicherter Unterschied feststellen, ob die Scheiben nach der Behandlung in verpuppungsreife oder in 72 Std alte Wirtslarven implantiert wurden, obschon die gesamte DifferenzierungskapazitÄt in jüngeren Wirten etwas vermindert zu sein scheint. 5. Die Wirkung von Mitomycin auf die Sockelbildung zeigt keine segmentspezifische AbhÄngigkeit, alle Beinteile differenzieren nach Mitomycinbehandlung annÄhernd gleich viele sockellose Borsten. 6. Wir diskutierten einige Möglichkeiten, wie Mitomycin spezifisch die Sockelbildung unterdrücken könnte und gingen auf Probleme ein, die sich aus den Versuchen mit verschiedenem Wirts- und Spenderalter ergaben.
    Notes: Summary 1. Treatment of male foreleg disks ofDrosophila melanogaster with Mitomycin Cin vitro (Conc. 0,002–1 mg/ml) results in the formation of bristle organs without sockets after implantation into larval hosts. The formation of sockets without bristles was never observed. The capacity to form differentiated structures is also restricted after Mitomycin treatment. 2. Mitomycin C reduces the number of bracts, but the formation of hairs and claws is only affected after applying higher concentrations of the drug. It is postulated that the normal differentiation of the bract depends on the formation of a socket or an entire bristle organ. 3. When disks of different age were used, ranging from 72 hrs after egg deposition to 8 hrs old pupae, it was shown that the formation of bristle organs without socket is increased with increasing age. 4. There is no statistical difference between the use of 72 hrs and 96 hrs old host larvae with respect to bristle numbers and socket formation. The overall differentiation capacity seems, however, to be somewhat lower in young hosts. 5. The different parts of the leg are all affected to approximately the same degree. 6. The results are discussed with respect to possible mechanisms by which Mitomycin C might specifically influence socket formation and to problems, which arose from experiments using hosts and donors of different ages.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Development genes and evolution 164 (1970), S. 303-312 
    ISSN: 1432-041X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Zusammenfassung 1. Injektion von Senfgaslösungen (HN-3) in verpuppungsreife Larven vonDrosophila melanogaster sowie diein vitro-Behandlung spätlarvaler männlicher Vorderbeinscheiben mit HN-3 bewirken folgendes Schädigungsmuster: Reduktion der Anzahl differenzierter Borsten und Trichome, Verkleinerung der gebildeten Beinteile, Veränderung des Borstenmusters und Differenzierung sockelloser Borsten ohne „bracts“. 2. Werden senfgasbehandelte Imaginalscheiben vor der Implantation in metamorphosierende Larvalwirte während 14 Tagen im Abdomen adulter Weibchen kultiviert, so differenzieren sich fast immer vollständige Borstenorgane, wobei Borsten der distalen Beinteile meistens von „bracts“ begleitet sind. 3. Nach Senfgasbehandlung wird die Transdetermination vollständig blockiert, obschon nach Einwirkung von 0,02 Μl HN-3/ml Insekten-Ringer die Beinimaginalscheiben während derin vivo-Kultur proliferieren. 4. Die Injektion von HN-3 in verpuppungsreifeDrosophila-Larven induziert somatische Mutationen. 5. In der Diskussion wird die Senfgaswirkung mit derjenigen von Mitomycin C verglichen und die Beeinflussung der Transdetermination durch HN-3 erörtert.
    Notes: Summary 1. Injection of nitrogen mustard (HN-3) into late third instar larvae ofDrosophila melanogaster and treatment of male foreleg disks with HN-3in vitro results in the following: formation of fewer bristles and hairs, reduction in size of leg parts, alteration of normal bristle patterns, and differentiation of bristle organs without sockets and bracts. 2. When disks, treated with HN-3, were cultivated in adult hosts for 14 days before transplantation into metamorphosing larvae, mostly complete bristle organs were formed, whereby bristles of distal leg parts usually form bracts. 3. Transdetermination is completely suppressed after HN-3-treatment, although proliferation occurs in disks treated with a concentration of 0,02 Μl HN-3 per ml Insect-Ringer. 4. Injection of HN-3 into late third instar larvae results in the induction of somatic mutations. 5. The effect of nitrogen mustard is compared with the effect of mitomycin C treatment and discussed with respect of the suppression of transdetermination.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Development genes and evolution 167 (1971), S. 367-369 
    ISSN: 1432-041X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Genetically marked thoracic imaginal disks ofDrosophila melanogaster were partially dissociated and reaggregated. After metamorphosis, combinations of dorsal proand mesothoracic disks gave rise to mosaics, whereas no such mosaics were formed in combinations of dorsal meso- and metathoracic disks. Adventitious bristles are formed by the metathoracic disk, but these were never integrated in a common pattern with mesothoracic bristles.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 5 (1949), S. 398-401 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The “turning to wood” of the cell wall, in which it can replace cellulose and pectin, which occurs in the bast fibres of flax and hemp seldomer, in others oftener, is a metabolic phenomenon dependent upon the race, age, and external conditions. It takes place in general (apart from special cases) in the oldest portions of the wall, although lignin can spread still further, and even beyond the cell wall. Its formation in the bast fibres, furthermore, does not have to go parallel with the formation of lignin (turning to wood) in the stalk. The turning to wood of the bast fibres stands in close connection with the capability for retting of the stalk, because this presupposes the pectins in the wall.
    Type of Medium: Electronic Resource
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