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  • 1
    Electronic Resource
    Electronic Resource
    Effect of thyroid hormone on somatomedin-C release from perfused rat liver (1989)
    Springer
    Cellular and molecular life sciences 45 (1989), S. 170-171 
    Details
    ISSN: 1420-9071
    Keywords: Thyroid hormone ; somatomedin-C ; perfused rat liver
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The effect of thyroid hormone on plasma somatomedin-C (SmC) level and on SmC release from perfused rat liver was investigated. Plasma SmC levels and liver tissue SmC were significantly increased in thyroxine-treated rats. Physiological doses of triiodothyronine increased SmC release and SmC concentration in the perfused rat liver. These results indicate that thyroid hormone directly enhances the synthesis and release of SmC in the rat.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01954863
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  • 2
    Electronic Resource
    Electronic Resource
    The alpha cell response to glucose change during perfusion of anti-insulin serum in pancreas isolated from normal rats (1985)
    Springer
    Diabetologia 28 (1985), S. 836-840 
    Details
    ISSN: 1432-0428
    Keywords: Alpha cells ; glucagon ; anti-insulin serum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To determine the effect of neutralization of endogenous insulin upon the glucagon response to a rise and fall of glucose concentration, pancreata isolated from normal rats were perfused with either a potent anti-pork insulin guinea pig serum or a nonimmune guinea pig serum for 30 min. During this period glucose concentration was changed from 100 mg/dl to either 130, 180 or 80 mg/dl for 10 min. Antiserum perfusion at 100 mg/dl caused an approximately two-fold increase in glucagon which was not suppressed by an increase in glucose concentration to either 130 or 180 mg/dl, although glucagon secretion was significantly suppressed in the control experiments in which nonimmune serum was perfused. However, the 0.38±0.21 ng/min rise in glucagon secretion in response to a reduction in glucose concentration to 80 mg/dl in the control experiments was not abolished by antiserum perfusion but, instead, was enhanced (2.66±0.60 ng/min). These findings suggest that insulin may be required for glucose-mediated suppression of glucagon in the isolated pancreas of normal rats but not for stimulation of glucagon secretion by mild glucopenia. Alternatively, neutralization of insulin-mediated release-inhibition of glucagon secretion may simply have altered alpha cell responsiveness in a direction that desensitized it nonspecifically to suppression and sensitized it to stimulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00291074
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  • 3
    Electronic Resource
    Electronic Resource
    Further confirmation of serotonin reduction in the neostriatum during hyperthermia-induced convulsions: a quantitative immunohistochemical study (1989)
    Springer
    Acta neuropathologica 77 (1989), S. 254-257 
    Details
    ISSN: 1432-0533
    Keywords: Serotonin ; Neostriatum ; Hyperthermia ; Seizure ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Changes occurring in serotonin neurons during hyperthermia and hyperthermia-induced convulsions were examined by quantiative immunohistochemistry. A marked increase in serotonin immunoreactivity was observed at the rostral and intermediate levels of the neostriatum of mice kept at high temperatures with no convulsions, and a significant reduction in serotonin immunoreactivity was verified throughout the neostiatum of mice which had hyperthermia-induced seizures. These results suggest that serotonin neurons change significantly during thermal stress and seizures, and that regional analysis is essential for an understanding of the role of serotonin neurons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687576
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  • 4
    Electronic Resource
    Electronic Resource
    Ambulatory blood pressure monitoring in elderly hypertensives treated with the new calcium antagonist, nilvadipine (1991)
    Springer
    European journal of clinical pharmacology 41 (1991), S. 255-257 
    Details
    ISSN: 1432-1041
    Keywords: Nilvadipine ; Hypertension ; elderly patient ; circadian rhythm ; ambulatory blood pressure monitoring (ABPM) ; adverse effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary. A newly developed calcium antagonist, nilvadipine, was administered to 7 hypertensive patients aged 75.6 y. Nilvadipine 4 mg b.d. decreased the average 24-h blood pressure significantly from 169/89 mm Hg to 152/81 mm Hg after 7 to 14 days without any change in the pulse rate. The circadian patterns of blood pressure and pulse rate were not affected by nilvadipine. Although the present study was a preliminary one done over a short period in a small number of patients, the results suggest that nilvadipine exerts an antihypertensive effect without altering the circadian pattern or the variability of blood pressure in elderly hypertensive patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315439
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  • 5
    Electronic Resource
    Electronic Resource
    Microvascular changes associated with postischaemic hypoperfusion in rats (1997)
    Springer
    Acta neurochirurgica 139 (1997), S. 670-677 
    Details
    ISSN: 0942-0940
    Keywords: Postischaemic hypoperfusion ; endothelial microvilli ; endothelial cell swelling ; electron microscope
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The present study was undertaken to explore the cause of postischaemic hypoperfusion through morphological observations of the microstructure of brain cortex capillaries in rats with postischaemic hypoperfusion. Sixteen rats were used. The left middle cerebral artery of each animal was occluded for one hour (n = 8) or 2 hours (n = 8) and was followed by reperfusion for 2 hours. The regional cerebral blood flow (rCBF) of the ischaemia induced brain cortex was monitored continuously during the experiment and the microstructure of the brain cortex capillaries was then observed under electron microscope. Postischaemic hypoperfusion was observed in both ischaemia groups. The rCBF after 0.5 hours of reperfusion was significantly lower in the 2-hour ischaemia group than in the one-hour ischaemia group. The number of endothelial microvilli (MV) per capillary in the one-hour ischaemia group did not differ significantly from the control (the right cortex capillaries), whereas it was significantly higher in the 2-hour ischaemia group (p 〈 0.05). The ratio of the inner diameter to the outer diameter of capillaries decreased significantly in both ischaemia groups, and the ratio in the 2-hour ischaemia group was significantly lower than that in the one-hour ischaemia group (p 〈 0.05). Thus the present study statistically revealed that as postischaemic perfusion of the brains decreases, the number of MV increases, and endothelial cells swell more markedly. These microvascular changes seem to represent morphological factors associated with postischaemic hypoperfusion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01412003
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  • 6
    Electronic Resource
    Electronic Resource
    The effect of Acetylcholinesterase inhibitor (SDZ ENA 713) for r-CBF and focal cerebral ischaemia (1993)
    Springer
    Acta neurochirurgica 124 (1993), S. 127-131 
    Details
    ISSN: 0942-0940
    Keywords: Acetylcholine ; SDZ ENA 713 ; acetylcholinesterase inhibitor ; focal cerebral ischaemia ; r-CBF
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The purpose of the present study was to examine the effect of Acetylcholinesterase inhibitor (AChEI) on r-CBF (group A) and its protecting effect on focal ischaemic cell damage (group B). The pial arterial diameter and the r-CBF were measured with a width analyzer and with a laser Doppler flowmeter through a cat cranial window on the ectosylvian gyrus. The ischaemic area was measured histologically. We used intravenous injection of AChEI([-](S)-N-ethyl-3-[(1-dimethyl-amino) ethyl]-N-methyl-phenylcarbamate, SDZENA713, Sands Pharmacy) to block AChE. Twenty minutes after injection AChEI (0.6 mg/kg) the pial arteriole dilated 108.5±1.8% and the r-CBF increased 115.4±2.6%. The pial arteriole dilated maximally to 137.6±6.5% at 120 minutes after injection and the r-CBF increased maximally to 137.1±19.5% at 60 minutes after injection. The protecting effect was evaluated using cats and 1 hour of occlusion of the middle cerebral artery (MCA). Twenty minutes after injection of AChEI, the pial arteriole dilated to 116.7±2.4% and the r-CBF increased to 111.9±2.6% significantly. During MC Aocclusion the r-CBF decreased to 24.7-41.4% in group B and 25.1–32.6% in sham group (group C). The pial arteriole dilated 145.0–184.0% in group C and 150.7–171.6% in group B during MCA occlusion and 30 minutes after reperfusion the pial arteriole returned to 120.0±3.3% in group C and 123.4±11.3% in group B. There were no significant changes in the r-CBF and in the vessel diameter between group B and C during the 2 hours after reperfusion. But 2.5 hours after reperfusion the pial arteriole began to redilate prominently in group C and 5 hours after reperfusion the pial arteriole redilated 118.3±4.2% in group B and 140.0±3.6% in group C. The percentage of infarcted area in sham animals (group C) measured 38.6±6.4% and significantly decreased to 26.2±7.8% in treated animals (group B). In conclusion, AChEI dilates cerebral arteries and increases CBF. AChEI protects ischaemic areas from parenchymal and vessel damage because of increasing collateral circulation in focal ischaemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01401134
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  • 7
    Electronic Resource
    Electronic Resource
    Effect of β-hydroxybutyrate and acetoacetate on insulin and glucagon secretion from perfused rat pancreas
    Amsterdam : Elsevier
    Archives of Biochemistry and Biophysics 257 (1987), S. 140-143 
    Details
    ISSN: 0003-9861
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0003-9861(87)90552-2
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Oxidation-induced increase in activity of angiotensin converting enzyme in the rat kidney
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 153 (1988), S. 1032-1037 
    Details
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0006-291X(88)81332-9
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  • 9
    Electronic Resource
    Electronic Resource
    Angiotensin converting enzyme predominates in the inner cortex and medulla of the rat kidney
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 144 (1987), S. 915-921 
    Details
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0006-291X(87)80051-7
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  • 10
    Electronic Resource
    Electronic Resource
    Structural differences among guinea pig Fc"γ"1"γ"2 receptors on macrophages, polymorphonuclear cells, and lymphocytes
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 172 (1990), S. 835-841 
    Details
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0006-291X(90)90751-8
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