ISSN:
1076-5174
Keywords:
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
,
Physics
Notes:
A series of 3,3-dimethyl-1-(isoxazol-3-yl)triazenes, potential anticancer agents, were studied by electron impact (EI) ionization and fast atom bombardment mass spectrometry. Their behaviour was compared with that of dacarbazine, 5-(3,3-dimethyl-1-triazenyl)-(1H)-imidazole-4-carboxamide, which is employed in the treatment of several neoplastic conditions. An interesting EI-generated decomposition pathway was observed, consisting in the primary formation of [NH2CH3]+ cations, involved in the metabolic pathway of triazenes, as the alkylating agent responsible for the anticancer properties of the drug. A higher thermodynamic stability of the examined compounds than decarbazine was observed, which reasonably reflects the higher chemical stability.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jms.1190301108
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