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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 63 (1984), S. 96-107 
    ISSN: 1432-0533
    Keywords: Hereditary coproporphyria ; Hereditary hepatic porphyrias ; Sural nerve biopsy ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In spite of several cases reported in the literature, the exact pathogenetic mechanism of neuropathic changes in porphyric neuropathy remains uncertain. Various authors have ascribed the neuropathologic findings to either a dying-back axonal degeneration or segmental demyelination. In recent years, the hypothesis of an axonal and myelinic disorder has received support by the demonstration of a combined and simultaneous involvement of both these structures. Such different opinions are also a consequence of the reduced number of detailed bioptic observations in the different forms of acute porphyria not only during acute phases but also between attacks. In this paper we report the results of light- and electronmicroscopic examination of two sural nerve biopsies from subjects with hereditary coproporphyria. The first was performed 6 months after an acute attack, the second specimen was obtained from a patient without acute attacks, who had clinical and electrophysiologic signs of a chronic progressive neuropathy. In both cases a dying-back axonal degeneration is considered the primary change. The pathogenetic mechanism of peripheral nerve lesions in porphyric neuropathy will be discussed finally.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 72 (1986), S. 103-110 
    ISSN: 1432-0533
    Keywords: Progressive systemic sclerosis ; Peripheral nervous system ; Electron microscope
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Progressive systemic sclerosis (PSS) is a chronic inflammatory disease of the connective tissue with involvement of the skin and other organs. The disease is characterized by an abnormal accumulation of collagen in all tissues and by microangiopathy. The involvement of the peripheral nervous system during PSS is very unusual and few cases are reported in the literature. A morphological study on the neuropathy associated with sclerodermia has been performed in rare cases. In this paper we demonstrate the role that the vascular lesions have in the pathogenesis of neuropathy during scleroderma. In particular, the primary role of the peripheral microangiopathy during PSS (observed in different clinical cases) is verified.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of organic chemistry 48 (1983), S. 4082-4087 
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 0223-5234
    Keywords: 1,2,3,3a-tetrahydropyrrolo[2,1-b]benzothiazol-1-ones ; 3,4,5,6,7,7a-hexahydro-2H-pyrrolo[2,1-b]thiazol-5-ones ; [^3H]flunitrazepam ; [^3H]muscimol ; [^3^5S]TBPS ; anticonvulsant activity ; stability study
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Tetrahedron Letters 22 (1981), S. 1455-1458 
    ISSN: 0040-4039
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Tetrahedron Letters 22 (1981), S. 1641-1644 
    ISSN: 0040-4039
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Neurological sciences 17 (1996), S. 283-286 
    ISSN: 1590-3478
    Keywords: Brain tumor ; Head injury ; Oligodendroglioma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Solo pochi dei casi riportati nella letteratura scientifica soddisfano pienamente i criteri stabiliti per accettare l'origine post-traumatica di alcune neoplasie endocraniche. Presentiamo il caso di un paziente il quale, molti anni dopo aver subito un trauma cranico commotivo nella regione parietale sinistra, ha manifestato una sintomatologia compatibile con un processo espansivo endocranico. Le neuroimmagini (TC e RM) hanno mostrato una estesa neoplasia nella regione temporo-parieto-occipitale sinistra. Una biopsia stereotassica ha evidenziato un glioma misto in continuità diretta con la cicatrice del pregresso trauma.
    Notes: Abstract Only a few cases reported in the literature fulfil the currently established criteria for accepting the traumatic origin of some intracranial tumors. A case of post-traumatic glioma is presented. Several years after sustaining a commotive left parietal trauma, our patient developed symptoms of intracranial tumor. Neuroimaging (CT and MRI) showed a large neoplasia in the left temporo-parietal-occipital region, and stereotactic biopsy revealed a mixed glioma in continuity with the scar resulting from the trauma.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Neurological sciences 16 (1995), S. 572-572 
    ISSN: 1590-3478
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1590-3478
    Keywords: progressive systemic sclerosis ; peripheral nervous system ; electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Viene presentato un caso di una paziente affetta da Sclerosi Sistemica Progressiva, caratterizzata dalla presenza di una polineuropatia ad esordio precoce accanto ai sintomi tipici della malattia. In letteratura tale associazione è stata descritta raramente. In questo lavoro viene descritto per la prima volta lo studio ultrastrutturale del nemo periferico affetto. Lo studio neuropatologico del nemo surale mostra una quasi completa perdita di fibre mieliniche. Le cellule di Schwann mostrano una anormale iperplasia della membrana basale con segni morfologici di denervazione. Di particolare interesse è la presenza di corpi di Luse (spindle-shaped banded structures) sia all'interno del citoplasma schwannico sia nell'endonevrio. Sulla base dei dati ultrastrutturali vengono discusse alcune ipotesi sul meccanismo patogenetico di questa neuropatia.
    Notes: Abstract We present the case of a woman with progressive systemic sclerosis (PSS) in whom the usual symptoms were preceded by a rapidly progressive peripheral neuropathy. Few cases of peripheral nerve involvement have been described. For the first time we report an ultrastructural study of an affected peripheral nerve and muscle. In the sural nerve we found an almost complete loss of myelinated fibers. Schwann cells showed an abnormal hyperplasia of their basal membranes and structural signs of denervation. Spindle-shaped banded structures were seen in the cytoplasm of Schwann cells and in the endoneurium. On the basis of these ultrastructural data some hypotheses on the pathogenetic mechanism of this neuropathy are discussed.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1590-3478
    Keywords: Peripheral neuropathy ; cerebral atrophy ; vitamin B12 deficiency ; folic acid deficiency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Viene presentato un caso di una donna di 56 anni che, a seguito di ripetute resezioni chirurgiche dell'intestino tenue presentò una polineuropatia soprattutto motoria degli arti inferiori a lenta progressione. Questa polineuropatia dovuta certamente a deficit di assorbimento di vitamine B12 e di folato, era associata ad un deterioramento intellettuale soprattutto a carico delle funzioni mnesiche. Lo studio ultramicroscopico del nervo surale ha dimostrato una marcata riduzione di ogni tipo di fibre mieliniche con degenerazione di tipo walleriano. Inoltre nel citoplasma delle cellule Schwann e o dei microfagi, si riscontravano residui mielinici. Non vi erano invece segni di degenerazione primaria assonale. I dati morfologici suggeriscono una demielinizzazione primaria.
    Notes: Abstract We present a case of a 56 year old woman who, in consequence of repeated surgical resections of the small bowel, developed a slowly progressive and mainly motor polyneuropathy affecting the lower limbs. The polyneurophaty due to a combined deficiency of vitamin B12 and folate, was associated with intellectual deterioration, envolving especially the mnesic functions. Light microscopy and ultrastructural study of sural nerve revealed: marked reduction of every order of myelinated fibers: aspects of wallerian-like myelin degeneration; various stages of myelin leaflet delamination into the cytoplasm of Schwann cells and/or macrophages; lack of alterations attributable to a primary axonal degeneration. The morphological results suggest a primary demyelination, followed secondarily by either axonal changes or some aspects of wallerian-like degeneration.
    Type of Medium: Electronic Resource
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