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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 70 (1992), S. 269-276 
    ISSN: 1432-1440
    Keywords: α1-Proteinase inhibitor ; Proteinase inhibitor ; Emphysema
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The role of the antiproteases α1-proteinase inhibitor (α1PI) and mucus proteinase inhibitor (MPI) in human lung emphysema was investigated by measuring their amount and functional activity against trypsin, leukocyte elastase, and pancreatic elastase in the bronchoalveolar lavage fluid (BALF). In addition, leukocyte elastase was quantified in the lavage samples by measuring the concentration of the elastase-α1Pl-complex. The study population consisted of 38 patients (5 nonsmokers, 8 former smokers, 25 smokers) with aquired emphysema (i.e., emphysema which is not caused by α1PI deficiency), and 44 individuals (16 nonsmokers, 8 former smokers, 20 smokers) without emphysema. No differences were found between patients with and without emphysema in the activities of α1PI and MPI, or in the concentration of α1PI The concentration of MPI was significantly higher in the BALF of patients with emphysema than in that of patients without emphysema (p = 0.025). A significantly higher concentration of elastase-α1PI complex was found in patients with emphysema than in those without emphysema (p = 0.041). This finding could reflect the higher proteinase burden to which patients with emphysema are exposed. The increase of MPI in lavage fluid of patients with emphysema seems to be the result of increased production in emphysematous lungs. However, it remains unclear why patients develop emphysema while showing an increased content of MPI.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0165-4608
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 250 (1974), S. 269-275 
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Hämolysate von 7 Psoriatikern und 7 Kontrollpersonen wurden mit 7α-3H-DHEA in Gegenwart eines Überschusses an NADPH inkubiert. Die anschließende Bestimmung Tritium-markierter C19-Steroide ergab bei den Psoriatikern im Vergleich zu den Kontrollpersonen eine signifikante Erhöhung der ADIOL-Bildung und eine signifikant verminderte Konzentration der 17-Oxosteroide DHEA, ADION, ANDRO und ÄTIO. Die Ergebnisse weisen auf eine NADPH-unabhängige Steigerung der 17β-Hydroxysteroid-oxidoreduktase in Erythrocyten von Psoriatikern hin, die auf einer quantitativen und/oder qualitativen Veränderung des Enzymproteins beruht.
    Notes: Summary Hemolysates of erythrocytes from psoriatic subjects and normal controls were incubated with 7α-3H-DHEA in the presence of excess NADPH. The analysis of3H-labelled C19-steroids revealed that in hemolyzed erythrocytes of psoriatics the formation of ADIOL was significantly enhanced, whereas the concentrations of such 17-oxosteroids as DHEA, ADION, ANDRO, and ETIO proved to be significantly lower than in the controls. Such findings suggested an NADPH-independent increased activity of 17β-hydroxysteroid oxidoreductase in erythrocytes of psoriatic subjects based on quantitative and/or qualitative alteration of the enzyme protein.
    Type of Medium: Electronic Resource
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