Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    ISSN: 1365-2826
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The aims of the present study were: 1) to compare the effect of two different chronic intermittent stressors i.e. cold-swimming versus ether, on the pituitary opioidergic system; 2) to evaluate the response of pituitary and plasma β-endorphin (βS-EP) to an acute stress in chronically stressed rats; and 3) to evaluate the effect of acetyl-l-carnitine treatment (10 mg/day/rat per os at night) on pituitary and plasma β-EP changes induced by two different types of chronic stress. The stressors were applied twice a day for 10 days. Rats were killed either before, during or after the last swimming or ether stress session. β-EP was measured by radioimmunoassay in anterior pituitary and in neurointermediate lobe extracts and in plasma. The following observations were made; 1) Chronic intermittent cold-swimming stress increased anterior pituitary contents and plasma β-EP levels; 2) both chronic intermittent cold-swimming stress and ether stress caused an increase of neurointermediate lobe β-EP contents; 3) as in control animals, rats exposed to chronic intermittent swimming stress reduced pituitary β-EP contents and raised plasma β-EP levels in response to the last acute swimming stress; 4) in contrast to control animals, rats exposed to chronic intermittent ether stress did not show any significant response of the pituitary-plasma opioidergic system to the last acute ether session; 5) the acetyl-l-carnitine treatment counteracted the changes evoked by chronic intermittent cold-swimming stress on the pituitary and plasma β-EP levels. The present data show that chronic intermittent ether stress impairs the capacity to respond to the acute stress and that acetyl-l-carnitine may modulate the changes of β-EP levels following chronic cold-swimming stress exposure.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Virchows Archiv 378 (1978), S. 153-159 
    ISSN: 1432-2307
    Keywords: Aorta ; Amyloidosis ; Adult life
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Zur Untersuchung gelangte die Aorta von 32 Erwachsenen mit einem Durchschnittsalter von 47,5 Lebensjahren. Zum Vergleich wurden 8 Aorten von ObduktionsfÄllen über 60 Lebensjahren, Anteile des linken Vorhofmyokards von ObduktionsfÄllen und 26 BiopsieprÄparate aus der Aorta abdominalis untersucht. In 53% der 32 ErwachsenenfÄlle unter 60 Jahren wurde Amyloidsubstanz in der Aorta mit Lokalisation in der Grenzzone zwischen Intima und Media sowie vor allem im inneren Drittel der Media festgestellt. Selten wurden Ablagerungen in der Peripherie von atheromatösen Herden und noch seltener im Atheromherd selbst beobachtet. Bei einem Vergleich zwischen Brust- und Bauchaorta war die Aorta thoracica intensiver und hÄufiger befallen. Aus den Untersuchungen wird der Schlu\ gezogen, da\ die Aortenamyloidose 1. bezüglich HÄufigkeit, QuantitÄt und Verteilung progressiv ist 2. nicht in wechselseitiger Beziehung zur AusprÄgung der Arteriosklerose zu stehen scheint, und 3. nicht einfach als senile Amyloidose verstanden werden darf. Sie stellt vielmehr eine besondere Form der kleinherdigen Amyloidablagerung dar, deren Krankheitswert jedoch unbedeutend ist.
    Notes: Summary Aortic amyloid deposits were found in 53% of adult subjects (mean age 47.5 years). They appeared to be localized mainly in the mediaintimal border zone and the internal third of the aortic media, and were not usually related to atherosclerotic lesions. The thoracic aorta was more extensively and frequently involved than the abdominal. It was concluded that aortic amyloidosis: 1. is progressive in its extent and distribution 2. does not seem to be related to atherosclerosis 3. should not be considered to be a form of senile amyloidosis, but rather a peculiar microfocal amyloidosis of the aorta.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 1432-1351
    Keywords: Rat ; Melatonin ; Circadian rhythm ; 5-hydroxytryptophan
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The rhythm in melatonin production in the rat is driven by a circadian rhythm in the pineal N-acetyltransferase (NAT) activity. Rats adapted to an artificial lighting regime of 12 h of light and 12 h of darkness per day were exposed to an 8-h advance of the light-dark regime accomplished by the shortening of one dark period; the effect of melatonin, triazolam and fluoxetine, together with 5-hydroxytryptophan, on the reentrainment of the NAT rhythm was studied. In control rats, the NAT rhythm was abolished during the first 3 cycles following the advance shift. It reappeared during the 4th cycle; however, the phase relationship between the evening rise in activity and the morning decline was still compressed. Melatonin accelerated the NAT rhythm reentrainment. In rats treated chronically with melatonin at the new dark onset, the rhythm had already reappeared during the 3rd cycle, in the middle of the advanced night, and during the 4th cycle, the phase relationship between the evening onset and the morning decline of the NAT activity was the same as before the advance shift. In rats treated chronically with melatonin at the old dark onset or in those treated with melatonin 8 h, 5 h and 2 h after the new dark onset during the 1st, 2nd and 3rd cycle, respectively, following the advance shift, the NAT rhythm reappeared during the 3rd cycle as well but in the last third of the advanced night only. Neither triazolam nor fluoxetine together with 5-hydroxytryptophan administered around the new dark onset facilitated NAT rhythm reentrainment after the 8-h advance of the light-dark cycle.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...