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  • 1
    ISSN: 0942-0940
    Keywords: Stereotactic irradiation ; convergent beam irradiation ; linear accelerator ; radiosurgery ; brain tumours
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A stereotactic convergent beam irradiation technique using a linear accelerator has been developed in order to precisely apply single high doses of up to 50 gray and more to brain lesions (radiosurgery). Accurate positioning of the patient and the target point of irradiation is an absolute requirement for this method. The stereotactic localization system developed for this purpose is described.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 125 (1993), S. 142-149 
    ISSN: 0942-0940
    Keywords: Stereotactic technique ; CT-guided stereotaxy ; computer-assisted treatment planning ; histological diagnosis ; brain neoplasms
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary On the base of a stereotactic device originally described by Riechert and Mundinger a three-dimensional localization and treatment planning system for CT-guided computer assisted stereotactic procedures has been developed. The experience with 338 patients, in which image guided stereotaxy has been used for the assessment of various intracerebral lesions, is presented. In 54 of these patients the cannula was introduced with a 20 MHz Doppler-probe positioned at the tip of the needle. A comparison of tissue specimens taken stereotactically with tissue material after tumour resection and/or autopsy was performed in 35 patients. The accuracy of the histological diagnosis was 88%. Bleeding as a complication due to the stereotactic intervention occurred in 8 patients (2.4%). Two of these patients had a fatal outcome (mortality: 0.6%). The morbidity (transient and permanent deterioration of the clinical status) was 1.2%.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1619-7089
    Keywords: Brachytherapy ; Glioma ; Positron emission tomography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We investigated whether 2-[18F]-fluoro-2-de-oxy-d-glucose (FDG) and carbon-11 methionine are suitable tracers to monitor the effects of therapy for low-grade gliomas. Ten patients with low-grade glioma without previous treatment were studied with FDG positron emission tomography. Additionally,l-[methyl-11C]-methionine uptake was measured in five subjects before and 1 year after computerized tomography (CT)-guided stereotactic and computer-assisted implantation of iodine-125 seeds. All scans were 3D-matched to CT, isodose volumes were determined, and changes in glucose metabolism and methionine uptake were evaluated in tumour and brain tissue as a function of radiation dose. After 1 year glucose metabolism was not significantly altered up to a radiation dose of 300 Gy, whereas methionine uptake showed a significant dose-dependent decrease. Higher rates of decline were found in tumours with high basal methionine incorporation activity before therapy. These data suggest that measurement of methionine uptake is more suitable than measurement of FDG uptake for monitoring therapeutic effects in low-grade gliomas.
    Type of Medium: Electronic Resource
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