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  • 1
    Electronic Resource
    Electronic Resource
    Platelet-activating factor and antiphospholipid antibodies in subarachnoid haemorrhage (1994)
    Springer
    Acta neurochirurgica 128 (1994), S. 144-149 
    Details
    ISSN: 0942-0940
    Keywords: Anti-phospholipid antibodies ; platelet-activating factor ; PAF-acetylhydrolase ; subarachnoid haemorrhage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The purpose of this study was to measure plasma platelet-activating factor (PAF) concentration, PAF-acetylhydrolase activities, anti-phospholipid antibody (aPLs) titers, and platelet function in patients with subarachnoid haemorrhage (SAH) and to assess the association of these variables with the development of cerebral vasospasm. Thirty-two patients with SAH due to ruptured cerebral aneurysm were studied. Plasma PAF concentration, PAF-acetylhydrolase activity, platelet count and aggregability, and plasma factor 4 (PF 4) concentrations were measured regularly until approximately 2 weeks after SAH. aPLs, including lupus anticoagulant and anti-cardiolipin IgG and IgM were measured within 3 days after SAH. Plasma PAF concentration in patients with SAH showed the highest value on the occasion during 5 to 9 days after SAH. The concentrations were higher in patients with infarction due to vasospasm than in patients without cerebral infarction on any occasions after SAH. Plasma PAF-acetylhydrolase activities did not change in patients, regardless of the presence of cerebral infarction after SAH. Increased platelet consumption and aggregability and higher concentrations of PF 4 were detected in patients with cerebral infarction and not in patients without cerebral infarction. The patients with cerebral infarction due to cerebral vasospasm had aPLs more frequently than the control volunteers. Our findings indicate that increased plasma PAF and aPLs may contribute to the pathogenesis of cerebral vasospasm after SAH.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01400665
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  • 2
    Electronic Resource
    Electronic Resource
    Anti-phospholipid antibodies and cerebral vasospasm following subarachnoid haemorrhage (1995)
    Springer
    Acta neurochirurgica 135 (1995), S. 191-197 
    Details
    ISSN: 0942-0940
    Keywords: Cerebral vasospasm ; subarachnoid haemorrhage ; lupus anticoagulant ; anti-cardiolipin antibodies ; platelet
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Delayed ischaemic deficits due to cerebral vasospasm contribute to the high morbidity and mortality rates associated with subarachnoid haemorrhage. We evaluated the usefulness of measuring anti-phospholipid antibodies (aPLs) for prediction of the occurrence of symptomatic vasospasm and the outcome after subarachnoid haemorrhage. 32 consecutive patients with subarachnoid haemorrhage due to ruptured cerebral aneurysms were studied. They were admitted and operated on within 72 hours after the onset of subarachnoid haemorrhage. aPLs such as lupus anticoagulants, anti-cardiolipin IgG and anti-cardiolipin IgM were measured repeatedly after admission. Furthermore, platelet count, platelet aggregability and plasma platelet factor 4 were also measured. Eleven among the 32 patients (34.4%) showed positive in the examination for aPLs. Although aPLs could not predict symptomatic vasospasm, once symptomatic vasospasm occurred, patients with aPLs frequently demonstrated cerebral infarction and there-fore their outcome was worse. aPLs were associated with a severe initial clinical grade and SAH grade on CT scan. Therefore it may explain the association of aPLs with worse outcome. aPLs were detected between 1 and 7 days. Four of 6 patients (67%) with aPLs became negative between 7 and 13 days after subarachnoid haemorrhage. The mechanism of transient aPLs is unclear but it is more likely to occur in the severer grade patients. The reduction in platelet count, the increased platelet aggregability, and the increased plasma platelet factor 4 concentration were also observed in aPLs-positive patients with symptomatic vasospasm.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02187767
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Comparison between segmental wall motion and wall thickening in patients with coronary artery disease using quantitative gated SPECT software (2000)
    Springer
    The international journal of cardiovascular imaging 16 (2000), S. 283-291 
    Details
    ISSN: 1573-0743
    Keywords: emission computed tomography ; radionuclide imaging ; regional ventricular function ; wall motion ; wall thickening
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study was performed to evaluate regional wall motion (WM) and wall thickening (WT) using gated myocardial perfusion single photon emission computed tomography (SPECT) and to determine their similarity and disparity in patients with coronary artery disease (CAD). A total of 44 patients underwent 1 day stress/rest (MIBI) gated SPECT. Commercially available quantitative analysis of gated SPECT (QGS) software was used to generate 3D surface display and cine-mode SPECT display. Left ventricle was divided into nine segments to score WM and WT from 0 (no abnormality) to 4 (severe abnormality) by six independent observers. Finally a mean score was calculated for each segment from the scores of six observers. There was fairly good correlation between WM and WT of individual segments (r = 0.62, p 〈 0.0001). Concordance rate (|WM − WT|≤1) was 85%. A large difference between WM and WT (WM − WT≥2) was observed in 15 segments, including 12 segments with greater WM abnormalities and 3 segments with greater WT abnormalities (lateral and inferior walls). Greater WM abnormalities were most commonly observed in anteroseptal segments especially in post coronary artery bypass grafting (CABG) patients. In conclusion, WM and WT showed similarity on QGS studies. However, these two parameters may be determined separately in gated SPECT studies for comprehensive and robust evaluation of the functional status of myocardium. Analyses based on WM assessment alone may lead to erroneous results especially in septal regions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026574431560
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    In response to the article by M.B. Imran, K. Morita, I. Adachi, M. Konno, N. Kubo, T. Mochizuki, C. Katoh, T. Kohya, A. Kitabatake, E. Tsukamoto & N. Tamaki Comparison between segmental wall motion and wall thickening in patients with coronary artery disease using quantitative gated SPECT software (2000)
    Springer
    The international journal of cardiovascular imaging 16 (2000), S. 481-484 
    Details
    ISSN: 1573-0743
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study was performed to evaluate regional wall motion (WM) and wall thickening (WT) using gated myocardial perfusion single photon emission computed tomography (SPECT) and to determine their similarity and disparity in patients with coronary artery disease. A total of 44 patients underwent 1 day stress/rest (MIBI) gated SPECT. Commercially available quantitative analysis of gated SPECT (QGS) software was used to generate 3D surface display and cine-mode SPECT display. Left ventricle was divided into nine segments to score WM and WT from 0 (no abnormality) to 4 (severe abnormality) by six independent observers. Finally a mean score was calculated for each segment from the scores of six observers. There was fairly good correlation between WM and WT of individual segments (r = 0.62, p 〈 0.0001). Concordance rate (|WM − WT| ≤ 1) was 85%. A large difference between WM and WT (WM − WT ≥ 2) was observed in 15 segments, including 12 segments with greater WM abnormalities and 3 segments with greater WT abnormalities (lateral and inferior walls). Greater WM abnormalities were most commonly observed in anteroseptal segments especially in post coronary artery bypass grafting patients. In conclusion, WM and WT showed similarity on QGS studies. However, these two parameters may be determined separately in gated SPECT studies for comprehensive and robust evaluation of the functional status of myocardium. Analyses based on WM assessment alone may lead to erroneous results especially in septal regions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1017368701916
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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