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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Marine biology 123 (1995), S. 639-644 
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The extracellular decomposing enzyme activities of marine bacteria, including 60 and 16 strains of Laminaria-thallus decomposing bacteria (LDB) and non-LDB, respectively, were determined against several algal polysaccharides. A number of LDB decomposed alginate, fucoidan, and cellulose, but not laminarin. Clear decomposing activity was not observed in the culture supernatant from nutrient broth, but was detected in that from a Laminaria-thallus medium, suggesting that decomposing enzymes were induced. During the incubation of LDB in Laminaria-thallus medium, depolymerized sugar materials with a wide range of molecular size were released into the culture fluid. Total sugars released into the culture fluid after 4 d of incubation amounted to a maximum of 95% of the initial content in the thallus tissues. These findings suggest that microbial decomposition of Laminaria thallus in sea water could be a good source of carbohydrates which may support the heterotrophic growth of marine organisms.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 52 (1997), S. 479-485 
    ISSN: 1432-1041
    Keywords: Key words Carteolol ; CYP2D6; biotransformation ; 8-hydroxycarteolol ; cDNA-expressed microsomes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objectives: To determine human cytochrome P450 isoform(s) (CYPs) involved in the metabolism of carteolol, the biotransformation of the compound was investigated in vitro using ten isoforms of human cytochrome P450 expressed in human AHH-1 TK ± cell lines. In addition, the inhibitory effects of carteolol on the activities of important CYP isoforms, namely, CYP1A2, 2C9, 2C19, 2E1, and 3A4, were examined. Results: Carteolol was metabolised to 8-hydroxycarteolol by CYP 2D6 with KM and Vmax values of 183 μmoles · l−1 and 26.09 pmol · min−1 · pmol−1 P450, respectively. CYP1A1, 1A2, 2A6, 2B6, 2C8, 2C9, 2C19, 2E1 and 3A4 were not involved in the metabolism of the compound. CYP2D6-mediated carteolol 8-hydroxylase activity was inhibited by quinidine, propranolol, nortriptyline, dextromethorphan, sparteine, bufuralol, and biperiden. Biperiden competitively inhibited the catalytic reaction with a Ki value of 0.45 μmoles · l−1. Carteolol did not affect the following catalytic reactions:␣CYP1A2-mediated (R)-warfarin 6-hydroxylation, CYP2C9-mediated tolbutamide methylhydroxylation, CYP2C19-mediated (S)-mephenytoin 4-hydroxylation, CYP2E1-mediated chlorzoxazone 6-hydroxylation, and CYP3A4-mediated testosterone 6β-hydroxylation. Conclusion: 8-Hydroxylation is the only cytochrome P450-catalyzed metabolic reaction of carteolol by its expressed microsomes, and CYP2D6 is the principal isoform of the enzyme involved in the catalytic reaction. Carteolol has neither stimulative nor inhibitory effects on CYP1A2, 2C9, 2C19, 2E1, and 3A4 activities.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1076
    Keywords: Colour Doppler ultrasonography ; Pulsed Doppler ultrasonography ; Cerebral blood flow velocity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Using a colour pulsed Doppler flow mapping system, we examined the intracranial arteries of 40 healthy infants. The anterior cerebral, basilar, intracranial internal carotid and middle cerebral arteries were visualized clearly enough to evaluate flow velocity at the success rates of 100%, 87.5%, 65% and 82.4%, respectively. In the anterior cerebral, intracranial internal carotid and middle cerebral arteries, the maximum blood flow velocity slightly decreased to a minimum at around 4–6h after birth, and then gradually increased. The minimum blood flow velocity pattern was similar. The maximum blood flow velocity in the basilar artery decreased from 0–3h, rapidly increased from 4–6h, and remained at a steady level thereafter. A possible mechanism for the chronological changes in the intracranial blood flow velocity is discussed.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 0942-0940
    Keywords: Keywords: Cortical mapping; motor evoked potential; somatosensory evoked potential.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary ¶ Objective. The aim of this study is to investigate the usefulness and problems with spinal motor evoked potential (MEP) recording, especially the reasons for failed recording. We report our personal experience over the last 8 years in patients with lesions adjacent to the primary motor cortex. Methods. MEP records of 50 consecutive patients were retrospectively reviewed. MEP was recorded by a catheter electrode inserted in the cervical epidural space. Stimulation electrodes were placed on the cortical surface during surgery. SEP recording was also performed in 29 of 50 patients. Results. MEP was obtained in 40 cases, and SEP was recorded in all 29 cases. The central sulcus was identified in 93% of patients in whom both MEP and SEP were performed, whereas in only 86% of patients who underwent only MEP. The main reason for MEP failure were inadequate exposure of the motor cortex, pre-existing hemiparesis and technical errors. Postoperative deterioration of motor function was closely related to intra-operative MEP changes. Conclusion. MEP is a useful tool to determine the motor cortex and to predict postoperative motor function. However, precise pre-operative craniotomy planning and combination with intra-operative SEP is essential to reduce the MEP failure.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 0942-0940
    Keywords: Keywords: Magnetic resonance imaging; vertebral artery; hemifacial spasm; microvascular decompression.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary  To discriminate between the various compressing vessels of the facial nerves in patients with hemifacial spasm, pre-operative oblique sagittal gradient-echo MR imaging was performed. Forty-two patients underwent pre-operative MR imaging and microvascular decompression. The MR images were divided according to findings into three groups as follows: Group A, a thick and/or long high-intensity line along the root exit zone (REZ) of the facial nerve; Group B, a thin and/or short high-intensity line along the REZ; and Group C, an unreliable image around the REZ. Fifteen images were classified as Group A, 19 as Group B, and 8 as Group C. In Group A, vertebral artery (VA) compression was confirmed intra-operatively in 12 cases and posterior inferior cerebellar artery (PICA) or anterior inferior cerebellar artery (AICA) compression in 3. In Group B, PICA or AICA compression was confirmed intra-operatively in all cases. In Group C, PICA or AICA compression was confirmed intra-operatively in 7 cases and no compression in one. In all cases of VA compression of the facial nerve, the oblique sagittal gradient-echo images demonstrated a thick and/or long high intensity line along the REZ. Oblique sagittal gradient-echo MR imaging is a useful pre-operative planning aid, which can predict the possibility of VA compression prior to microvascular decompression for hemifacial spasm.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Large (3.6 x 3.6 mm2) chips of the SiC DACFET were fabricated and mounted inTO220 packages. The drain-source avalanche breakdown voltage without any gate bias(Vgs=0V) is measured to be 〉1400V. The SiC DACFET keeps the normally-off characteristicseven at 150°C. Ron and specific Ron of the SiC DACFET is measured to be 62mΩ and 6.7mΩcm2 at RT while those at 150°C change to 107 mΩ and 11.6 mΩcm2. The 400V / 3 kWDC-DC switched-mode power-conversion circuit with 100kHz switching was fabricated usingthe SiC DACFET and the SiC SBD. The turn-off switching loss reduces dramatically usingthe SiC-DACFET down to 77μJ/pulse which is less than 1/10 of that using the Si-IGBT
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 264-268 (Feb. 1998), p. 243-246 
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 14 (1987), S. 0 
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: An example of red cells having no reaction with any Rh antisera was found in a Japanese woman. Results of a serological investigation of the family indicated the action of a ‘regulator’ gene. Her serum contained an antibody which agglutinated all cells of common Rh types, except for Rhnull, by the saline, anti-globulin and papain techniques.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 73 (1976), S. 127-132 
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 130 (1985), S. 939-944 
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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