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  • 1
    Electronic Resource
    Electronic Resource
    Growth activity of tumors at different intracranial structures: immunohistochemical study with bromodeoxyuridine (1986)
    Springer
    Acta neuropathologica 71 (1986), S. 15-18 
    Details
    ISSN: 1432-0533
    Keywords: Brain tumor ; Brain metastasis ; Walker 256 tumor ; Bromodeoxyuridine (BrdU) ; Glial fibrillary acidic protein (GFAP)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To elucidate the environmental influence on the growth of a tumor, bromodeoxyuridine (BrdU) uptake in multiple tumor foci within the intracranial cavity was studied immunohistochemically with a monoclonal antibody. Walker 256 tumor implanted intracerebrally produced multifocal tumors presented as (1) intraparenchymal solid tumor, (2) tumor in the choroid plexus, and (3) leptomeningeal dissemination. The BrdU-labeling indices, or the S-phase fractions (% of nuclei labeled by BrdU divided by the number of tumor cell nuclei scored; LI), of those tumors were 48.4±1.1, 59.1±1.3, and 27.9±5.9, respectively (means ± SEM). These differences in LI, or the tumor growth activity, are discussed in relation to the different environmental conditions in different host structures. These host structure-related modification of tumor growth would be important in evaluating the proliferative activity of tumors growing at various intracranial structures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687956
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  • 2
    Electronic Resource
    Electronic Resource
    Localization and significance of peanut agglutinin-binding sites on ependymoma cells (1990)
    Springer
    Acta neuropathologica 79 (1990), S. 634-639 
    Details
    ISSN: 1432-0533
    Keywords: Peanut agglutinin (PNA) ; Human brain tumor ; Ependymoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary It has been suggested that peanut agglutinin (PNA)-binding sites in benign and malignant tissues were quite different. To clarify the difference of PNA-binding sites between benign and malignant ependymoma, PNA-binding sites are investigated on the surface membrane of tissues from benign and malignant ependymomas and cultured ependymoma cells. In four of five malignant ependymoma cases, PNA binding occurred in a diffuse cell membrane fashion or granular intracytoplasmic fashion without neuraminidase treatment. On the other hand, PNA binding was observed without neuraminidase treatment in only two of eight benign ependymoma cases. After neuraminidase treatment, all of our benign and malignant ependymoma cases evidenced PNA binding. PNA binding was clearly evident on the cell membrane of ependymoma cells which were able to express organotypic structures, that is, to form ependymal rosettes after neuraminidase treatment. Normal rat ependymal cells showed PNA binding only after neuraminidase treatment. These findings suggest that the masking of PNA-binding sites of ependymoma cells by sialic acid may be correlated with tumor cell differentiation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294241
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  • 3
    Electronic Resource
    Electronic Resource
    Accumulation of amyloid in pituitary adenomas (1985)
    Springer
    Acta neuropathologica 68 (1985), S. 87-92 
    Details
    ISSN: 1432-0533
    Keywords: Pituitary neoplasm ; Anterior pituitary hormone ; Amyloid ; Electron microscopy ; Bromocriptine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The accumulation of amyloid in pituitary adenomas was examined in relation to the types of adenoma and the effect of bromocriptine treatment. Amyloid had accumulated in 34 of 48 adenomas (71%). The occurrence in prolactin-secreting adenomas and growth hormone-secreting adenomas was 79%, respectively, while that in non-functioning adenomas was 50%. Treatment with bromocriptine enhanced the occurrence and extent of the amyloid accumulation in prolactin- or growth hormone-secreting adenomas. Electron microscopy revealed the initial appearance of the amyloid fibrils in the smooth endoplasmic reticulum and a possible sequential process of their release from the cells. The presence of secretory granules in vesicles containing amyloid fibrils and their simultaneous release with amyloid fibrils suggested that degradation of secretory granules was involved in the formation of amyloid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688628
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  • 4
    Electronic Resource
    Electronic Resource
    Initial and postoperative hyponatremia associated with pituitary adenoma: A case report (1997)
    Springer
    Acta neurochirurgica 139 (1997), S. 987-991 
    Details
    ISSN: 0942-0940
    Keywords: Hyponatraemia ; syndrome of inappropriate secretion of antidiuretic hormone (SIADH) ; cerebral salt wasting syndrome (CSW) ; fludrocortisone acetate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This 67 year-old man experienced 3 episodes of symptomatic hyponatraemia. Radiological examination revealed a sellar lesion and the tumour was removed via the transsphenoidal route. Thereafter, he simultaneously developed intractable diabetes insipidus and serious hyponatraemia with persistent natriuresis. His level of atrial natriuretic peptide was not significantly elevated, however, his plasma aldosterone concentration was low. The oral administration of salt gradually improved his hyponatraemia as well as the coincident symptoms. By the administration of a mineralocorticoid, fludrocortisone acetate, we succeeded in maintaining his serum sodium level without salt replacement. We discuss the mechanism(s) and treatment of hyponatraemia associated with pituitary tumour.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01411311
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  • 5
    Electronic Resource
    Electronic Resource
    Expression of PDGF, PDGF-Receptor, EGF-Receptor and sex hormone receptors on meningioma (1994)
    Springer
    Acta neurochirurgica 131 (1994), S. 289-293 
    Details
    ISSN: 0942-0940
    Keywords: Meningioma ; growth factor ; sex hormone ; receptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The expression of platelet derived growth factors (PDGF), the PDGF-Receptor (R) (α and Β types), epidermal growth factor (EGF)-Receptor (R) and sex hormone (oestrogen and progesterone) receptors was studied in 22 meningiomas. All tumours were PDGF-R Β type positive and 21 (95%) were PDGF positive. Only 2 (9%) were PDGF-R α type positive, 13 (59%) were EGF-R positive. The expression of these proteins was not related to the histological type or the malignancy of the meningiomas although the expression of PDGF and PDGF-R Β tended to be stronger in malignant meningiomas. Oestrogen and progesterone receptor protein were examined in 19 patients (10 females and 9 males). None of the meningioma cells revealed oestrogen receptor protein while 17 (89%) of the 19 meningiomas were positive for progestrone receptor protein. The expression of progesterone receptor was not related to histological type or malignancy. Our studies suggest that the autocrine system, through PDGF and PDGF-R type Β, may play an important role in the tumourigenicity of meningiomas. EGF-R was present in almost half and progesterone receptor in most of the meningiomas. There was no correlation between the expression of either PDGF, PDGF-R or EGF-R and the expression of progesterone receptor protein.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01808629
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  • 6
    Electronic Resource
    Electronic Resource
    Cytochrome oxidase activity during acute focal ischaemia in rat brain (1996)
    Springer
    Acta neurochirurgica 138 (1996), S. 1126-1131 
    Details
    ISSN: 0942-0940
    Keywords: Cerebral ischaemia ; ischaemic brain damage ; cytochrome oxidase ; middle cerebral artery occlusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An enzyme-histochemical technique was used to examine the changes in cytochrome oxidase activity during acute focal ischaemia in the rat. In the somatosensory cortex, the enzyme activity began to increase significantly (p 〈 0.01) 1 hour after middle cerebral artery occlusion (MCAO) and continued to increase up to 3 hours, during which ischaemic cell damage was not detected. In the striatum, the enzyme activity increased significantly (p 〈 0.01) 1 hour after MCAO in the absence of morphological evidence of ischaemic cell damage; a peak activity was reached at 2 hours, and began to decline 3 hours after MCAO when moderate ischaemic change was detected. In both cortical and subcortical areas, the enzyme activity tended to decrease from 4 hours after MCAO, and was reduced to a level similar to or below that of the non-ischaemic hemisphere 5 hours after MCAO, when severe ischaemic damage was demonstrated. The relation of this transient increase of cytochrome oxidase activity in the early stage of acute ischaemia and the hypermetabolism of neuronal cells during ischaemic insult was discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01412318
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  • 7
    Electronic Resource
    Electronic Resource
    Intracranial intraparenchymal schwannoma: Report of three cases (1997)
    Springer
    Acta neurochirurgica 139 (1997), S. 756-760 
    Details
    ISSN: 0942-0940
    Keywords: Brain tumour ; intraparenchymal tumour ; schwannoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Intracranial intraparenchymal schwannomas are rare. We report three patients with an intracranial intraparenchymal schwannoma and discuss the clinical and neuroradiological aspects of this particular tumour. The patients were a 21-year-old male, a 64-year-old female and a 17-year-old male. The tumours were located in cerebrum in two patients and the cerebellum in one patient. Computerized tomography (CT) scans demonstrated a slightly high density area with homogeneous enhancement by contrast medium. Magnetic resonance imaging (MRI) showed slightly low signal intensity on the T1-weighted image, high or mixed signal intensity on the T2-weighted image and homogeneous enhancement by gadolinium diethylene triamine penta-acetic acid (Gd-DTPA). Radiological studies revealed cystic components in 2 of the 3 patients. All tumours were firm, well-demarcated, and completely removed. The diagnosis of schwannoma was derived from histological and immunohistochemical studies in all 3 cases; 2 cases were also examined by electron microscopy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01420049
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  • 8
    Electronic Resource
    Electronic Resource
    Clinical Features of Moyamoya Disease in Sibling Relations Under 15 Years of Age (1998)
    Springer
    Acta neurochirurgica 140 (1998), S. 455-458 
    Details
    ISSN: 0942-0940
    Keywords: Keywords: Moyamoya disease; paediatric; sibling relations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This study was undertaken to define the clinical features of moyamoya disease in sibling relations less than 15 years of age. We analysed five pairs of siblings (6 boys, 4 girls) with moyamoya disease from among 56 moyamoya patients less than 15 years of age. Of 56 paediatric patients with moyamoya disease, 5 were sibling pairs. At onset of the disease, all patients were under 10 years of age. Clinical manifestations in the proband and the affected sibling tended to present as transient ischaemic attacks; none of the 10 patients presented with intracranical haemorrhage. The probands were not always the older sibling, however, the time lapse between disease onset in the proband and his/her sibling was less than one year. Among the sibling pairs, there was no striking difference in disease staging based on angiographic findings. The incidence of sibling occurrence of moyamoya disease appears to be higher than previously assumed and the family of children with moyamoya disease should be cautioned that their other children have an increased risk of developing the illness.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010050124
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  • 9
    Electronic Resource
    Electronic Resource
    Multiple Cerebral Arteriovenous Malformations (AVMs) Associated with Spinal AVM (1999)
    Springer
    Acta neurochirurgica 141 (1999), S. 315-319 
    Details
    ISSN: 0942-0940
    Keywords: Keywords: Multiple; cerebral arteriovenous malformations; spinal arteriovenous malformations.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary  The co-existence of multiple cerebral arteriovenous malformations (AVMs) and a spinal AVM is extremely rare. A 22-year-old man suddenly developed severe headache. Computed tomography (CT) scan showed intracerebral haemorrhage in the left occipital lobe. Cerebral angiography revealed eight AVMs; four were in the right frontal lobe and two each were in the right temporal and left occipital lobe, respectively. A huge high-flow spinal AVM was found incidentally. He had no other vascular lesions such as hereditary haemorrhagic telangiectasia. A left occipital craniotomy was performed and the ruptured left occipital AVMs were removed. Further therapeutic treatment was refused. To our knowledge, except for one autopsy case, this is the first reported patient with multiple cerebral AVMs with a spinal AVM. We discuss the characteristics of this case and review reported cases with cerebral and spinal AVMs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010050303
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  • 10
    Electronic Resource
    Electronic Resource
    Distribution of mouse interferon-β in normal and brain tumour-bearing mice (1991)
    Springer
    Acta neurochirurgica 109 (1991), S. 46-51 
    Details
    ISSN: 0942-0940
    Keywords: Mouse interferon ; mouse glioma ; pharmacokinetics ; radioassay ; autoradiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The distribution of125I-labelled recombinant mouse interferon-β (rMuIFN-β) in normal and glioma (203 glioma) bearing mice was studied by radioassay and macro-autoradiography at 15 and 30 min after a single intravenous injection. The level of rMuIFN-β in the spleen was about 20-fold higher than in serum. Concentrations higher than the serum level was detected in the lung, liver and kidney. The concentration of rMuIFN-β in the brain was 8% of the serum level and the concentration in the glioma 30 min after administration was about 10-fold higher than in normal mouse brain. Macro-autoradiographic study demonstrated a wide distribution range and selective uptake in glioma tissue. Furthermore, we found that mouse gliomas were sensitive to mouse IFN-β. Our findings demonstrate that in the mouse glioma model, intravenously administered interferon reaches the tumour.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01405697
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